Cefquinome sulfate injection and process for producing the same

Abstract

The invention relates to a preparation method of a medicine, in particular to a cefquinome sulfate injection and a preparation process thereof. The cefquinome sulfate injection consists of cefquinome sulfate micro-powder which contains not less than 50-300g of cefquinome, 0.4-40g of antioxidant and a fat or ester organic solvent which is added to be 10,000ml. The preparation process is as follows: the antioxidant is dissolved into the fat or ester organic solvent, the mixture is filtrated into a mixing tank, added with the cefquinome sulfate micro-powder, stirred evenly and milled through a colloid mill, thus even suspension is made, and then the suspension is stirred, separately filled and sterilized. The cefquinome sulfate injection and the preparation process solve the problem of no domestic fourth generation cefamandole antibiotic which is special for animals existing in the prior art. The product prepared has wider antimicrobial spectrum, stronger antibacterial activity and more stable Beta-lactamase for bacteria compared with the third generation cephalosporin, fills up the gap of no domestic fourth generation cefamandole antibiotic preparation which is special for animals, and the whole preparation process is simple and practicable.

Description

technical field [0001] The invention relates to a preparation method of medicines, in particular to a cefquinome sulfate injection and a preparation process thereof. technical background [0002] my country's animal husbandry industry is mainly the breeding of food animals, so drug residues and cross-resistance with human drugs must be considered when using drugs. In view of this, the Ministry of Agriculture has very strict approval of veterinary antibacterial drugs, and actively promotes For veterinary medicine only. And animal-specific cephalosporin antibiotics currently only use ceftiofur (third generation) in domestic veterinary clinics, and cefquinome sulfate is the only fourth-generation animal-specific cephalosporin antibiotic successfully developed by German Hoechst Company and British Intervet Company. It is sold in various countries in Europe, but there is still no cefquinome sulfate raw material and its preparations on the market in China. Contents of the invent...

AI Technical Summary

Problems solved by technology

And animal-specific cephalosporin antibiotics currently only use ceftiofur (third generation) in domestic veterinary clinics, and cefquinome sulfate is the only fourth-generation animal-specific cephalosporin antibiotic successfully developed by German Hoechst Company and British Intervet Company. It is sold in various European countries, but there is still no cefquinome sulfate raw material and its preparations on the market in China