Pseudoephedrine hydrochloride oral administration solution and method of preparing the same

An oral solution, the technology of pseudoephedrine memin, which is applied in the field of medicine, can solve the problems of difficult to accurately control the dose, difficult to take, and poor drug efficacy, and achieve the effects of quick onset, easy production and operation, and good production stability

Inactive Publication Date: 2009-01-21
扬州市三药制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Pseudoephedrine hydrochloride, dextromethorphan hydrobromide, and chloramine maleate, as western medicine compound preparations, have a certain curative effect on cough caused by acute upper respiratory tract infection. The solid preparation of Meimin pseudoephedrine compound is relatively convenient to carry as a family backup drug, but it is still difficult to take for children, with poor compliance, difficult to accurately control the dosage, and poor drug efficacy.

Method used

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Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0017] 1. Formula:

[0018] Prescription volume: based on 1000ml product

[0019] Pseudoephedrine hydrochloride 3g Chloramine maleate 0.2g

[0020] Dextromethorphan Hydrobromide 1g Citric Acid 1.5g

[0021] Sucrose 200g Glycerin 120g

[0022] Sodium Benzoate 1.5g Stevia 3g

[0023] Carmine 0.1g Orange essence 10g

[0024] Second, the process steps:

[0025] 1. Making simple syrup

[0026] Add an appropriate amount of sucrose to boiling purified water, stir until completely dissolved, keep at 95°C±5°C for 50 minutes, and filter while hot.

[0027] 2. Add an appropriate amount of purified water into the liquid mixing tank and start stirring. Add pseudoephedrine hydrochloride, dextromethorphan hydrobromide, chlorpheniramine maleate, citric acid, glycerin, sodium benzoate, stevioside, simple syrup, and essence into the liquid preparation tank in sequence. filter machine.

[0028] 3. Taking method and dosage:

[0029] Adults and children over 12 years old: 10ml each time,...

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PUM

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Abstract

A dextromethorphan hydrobromide, chlorphenamine maleate and pseudoephedrine hydrochloride oral solution and a preparation method thereof relate to the technical field of medicine, in particular to a preparation method of a western medicine. The preparation method comprises the following steps: sucrose is firstly dissolved in purified water and is made into simple syrup; then the purified water, pseudoephedrine hydrochloride, dextromethorphan hydrobromide, chlorphenamine maleate, a flavouring agent, glycerol, a preservative and the simple syrup are added into a liquid preparation tank, stirred until all components are absolutely dissolved, and then filtrated by a press filter. The oral solution is simple in preparation process, is easy for production and operation, is good in production stability, reliable product quality with fragrant and sweet fruit taste, and children are willing to take the solution. The solution has good compliance, the dosage of the solution can be exactly determined according to the weights or the ages of the children. The solution is not needed to be disintegrated and dissolved after being taken, can be directly absorbed by human body and can take effect quickly.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a preparation method of western medicine. Background technique [0002] Pseudoephedrine hydrochloride, dextromethorphan hydrobromide, and chloramine maleate, as western medicine compound preparations, have a certain curative effect on cough caused by acute upper respiratory tract infection. The compound solid preparation of Meimin pseudoephedrine is relatively convenient to carry as a family backup medicine, but it is still difficult to take for children, with poor compliance, difficult to accurately control the dose, and poor drug efficacy. Contents of the invention [0003] The purpose of the present invention is to invent a memin pseudoephedrine oral solution which is convenient for children to take and has good drug efficacy. [0004] In addition to the active ingredients of pseudoephedrine hydrochloride, dextromethorphan hydrobromide and clonamine maleate, the invention ...

Claims

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Application Information

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IPC IPC(8): A61K31/485A61K31/137A61P11/14A61P31/16
Inventor解家顺祝瑞章
Owner扬州市三药制药有限公司