Polymer nanometer array electrochemical biological sensor

A biosensor, nanoarray technology, applied in scientific instruments, instruments, material analysis by electromagnetic means, etc., can solve the problems of inability to meet actual detection, low sensitivity of biosensors, etc., to improve stability and sensitivity, and improve sensitivity. Effect

Inactive Publication Date: 2009-01-28
中国医科大学 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The biosensor sensitivity of this polymer nanomaterial is much lower than that of nanogold or carbon nanotubes, which cannot meet the needs of actual detection.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] A polymer nano-array electrochemical biosensor, which includes the following three parts: a supporting electrode, a polymer fixedly connected to the supporting electrode, and a biosensing element fixedly connected to the polymer; it is characterized in that: the The morphology of the polymer is an array of nanofibers or nanotubes arranged in a direction. The material used for the supporting electrode is graphite, and the electrode is a highly oriented pyrolysis graphite electrode (HOPGE).

[0046] In the polymer nano-array electrochemical biosensor, the above-mentioned polymer array nanofibers or array nanotubes on the supporting electrodes are synthesized using nanoporous alumina built on the electrodes as a template. The so-called "synthesis" is specifically: nanotubes can be single-layer or multi-layer; nanotubes can be composed of single chains or multi-chains; the morphology of the array nanofibers or array nanotubes can be controlled by controlling the polymerizat...

Embodiment 2

[0052] The content of this embodiment is basically the same as that of Embodiment 1, the difference is that:

[0053] 1) The material used for the supporting electrodes is gold;

[0054] 2) The method for depositing an aluminum film on the supporting electrode is specifically chemical deposition;

[0055] 3) Apply chemical methods to initiate polymerization when constructing polymer array nanofibers or array nanotube arrays on the support electrode through alumina templates with nanohole arrays. The specific method is: use monomers and initiators to Polymerization to form a non-conductive polymer: array nanofibers or array nanotubes; the specific monomer is pyrrole (pyrrole); the specific initiator is I 2 ;

[0056] 4) After depositing the aluminum film on the supporting electrode, constructing an alumina template with a nanopore array, and then forming a polymer array nanofiber or a polymer nanotube through the alumina template, the alumina template needs to be removed, spe...

Embodiment 3

[0058] The content of this embodiment is basically the same as that of Embodiment 1, the difference is that:

[0059] 1) The supporting electrode is specifically a carbon electrode (GCE);

[0060] 2) The method for depositing an aluminum film on a supporting electrode is specifically electrochemical deposition;

[0061] 3) The application of chemical methods to initiate polymerization, the specific method is: using monomers and initiators to co-polymerize to form non-conductive polymers: array nanofibers or array nanotubes; the monomer is specifically thiophene (thiophene); the initiation The agent is specifically CH 2 (C 10 h 6 SO 3 Na) 2 ;

[0062] 4) After depositing the aluminum film on the supporting electrode, constructing an alumina template with a nanopore array, and then forming a polymer array nanofiber or polymer nanotube through the alumina template, the alumina template needs to be removed, specifically mechanically polished method.

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Abstract

The invention discloses an electrochemical biological sensor with a polymer nano array, which comprises the following three parts: a supporting electrode, polymers that are combined on the supporting electrode and a biological sensing element that is connected with the polymers. The electrochemical biological sensor is characterized in that the polymers take the shape of a nano fiber array or a nanotube array with permutation directivity. Compared with the existing electrochemical biological sensing techniques, the electrochemical biological sensor with the polymer nano array is characterized by simple techniques and high testing sensitivity, has enormous application prospect and can produce considerable economic and social benefits.

Description

Technical field: [0001] The invention relates to chemistry, material science and sensing testing technology, and particularly provides a polymer nano-array electrochemical biosensor. Background technique: [0002] A brief introduction to the relevant technical status of electrochemical biosensors is as follows: [0003] 1. Conductive polymers have been widely and deeply used in electrochemical biosensors. In 1986, Foulds and Lowe embedded glucose oxidase (GOD) in pyrrole polymers and constructed an enzyme sensor, which opened the prelude to the construction of biosensors with conductive polymers. Subsequently, many scholars immobilized different enzymes, coenzymes, antibodies, nucleic acids and their derivatives, and even biological substances such as cells and tissues in different conductive polymers to form various new biosensors. The main features of conductive polymer biosensors are strong response performance and simple and controllable fabrication process. For a lon...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/327
Inventor 常海欣关一夫袁莹石南林
Owner 中国医科大学
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