Alkanna tinctoria drug loading nano fiber, preparation and application thereof

A drug-loaded nanometer and nanofiber technology, which is applied in fiber treatment, fiber chemical characteristics, anti-tumor drugs, etc., to achieve the effect of simple preparation process, good biocompatibility, and reduced toxic and side effects

Inactive Publication Date: 2009-02-04
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Method used

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  • Alkanna tinctoria drug loading nano fiber, preparation and application thereof
  • Alkanna tinctoria drug loading nano fiber, preparation and application thereof
  • Alkanna tinctoria drug loading nano fiber, preparation and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0026] Dissolve 0.0043g of shikonin in 5mL of chloroform, add 0.4045g of polyεcaprolactone (PCL) (Mw≈100,000) under stirring condition, and ultrasonicate to make it into a homogeneous solution. Pour the prepared solution into a 5mL syringe, and use a right-angle flat-mouth spinneret made of a 9-gauge needle. The flow rate of the solution at the spinneret is 0.6mL / h, the applied voltage is 20kV, and the distance between the two poles is 20cm.

[0027] The result is as figure 1 As shown, the obtained shikonin / PCL drug-loaded fibers have a diameter of about 10 μm. The fiber surface is flat and smooth, and the drug is highly dispersed in the fiber substrate PCL.

Embodiment 2

[0029] Dissolve 0.0204g β, β-dimethylacrylshikonin (β, β-dimethylacrylshikonin) in a mixed solution of 4 mL chloroform and acetone (3:1, v / v), and add 0.4080 g PLGA ( Lactide:glycolide=75:25, Mw≈100,000), sonicated to make a homogeneous solution. Pour the prepared solution into a 5mL syringe, and use a right-angle flat-mouth spinneret made of a No. 8 needle. The flow rate of the solution at the spinneret is 0.8mL / h, the applied voltage is 22kV, and the distance between the two poles is 15cm.

[0030] The obtained β, β-dimethylacryloylshikonin / PLGA drug-loaded fiber has a diameter of about 12 μm. The fiber surface is flat and smooth, and the drug is highly dispersed in the fiber substrate PLGA.

Embodiment 3

[0032] Dissolve 0.0412g of acetylshikonin in 13.8mL of chloroform, add 0.4136g of PLLA (Mw≈100,000) under stirring conditions, and sonicate to make a homogeneous solution. Pour the prepared solution into a 5mL syringe, and use a right-angle flat-mouth spinneret made of a 9-gauge needle. The flow rate of the solution at the spinneret was 1.0 mL / h, the applied voltage was 25 kV, and the distance between the two poles was 15 cm.

[0033] The obtained acetylshikonin / PLLA drug-loaded fiber has a diameter of about 3 μm. The fiber surface is flat and smooth, and the drug is highly dispersed in the fiber substrate PLLA.

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Abstract

The invention relates to lithospermum medicinal nano fiber, and a preparation method and an application thereof; the fiber is a kind of nano fiber with the effective components of lithospermum; the effective components of lithospermum are evenly distributed in the fiber and account for 0.001 weight percent to 30 weight percent of the fiber; the preparation method comprises the following steps: the effective components of lithospermum are dissolved in organic solvent together with polymeric materials to prepare spinning solution, and then prepare the lithospermum nano fiber through an electrospinning process; application: depending on different curing parts or curing purposes, the fiber is processed and prepared to be taken orally, skin penetrative or implanted into a drug delivery system to cure injuries, cancer or resist oxidation. The lithospermum medicinal fiber has the advantages of simple preparation process, medicine release, good biological compatibility and the like.

Description

technical field [0001] The invention belongs to the field of drug-loaded nanofibers, in particular to a comfrey drug-loaded nanofiber and its preparation and application. Background technique [0002] Comfrey is a perennial herb of the Boraginaceae family, which was recorded as early as in "Shen Nong's Materia Medica". "Chinese Pharmacopoeia" 2005 edition records that it is the dried root of Arnebia euchroma (Royle) Johnst or Arnebia guttata Bunge, a plant of the family Boraginaceae. It has the effects of cooling blood, promoting blood circulation, detoxifying and penetrating rashes. It is mainly used for diseases such as blood heat and toxins, purple and black spots, impermeable measles, sores, eczema, and water and fire burns. It is one of the commonly used traditional Chinese medicines for the clinical treatment of skin diseases in my country. Comfrey contains a variety of chemical components, among which naphthoquinones have the highest content and have a variety of bi...

Claims

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Application Information

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IPC IPC(8): D01F1/10D01F6/92D01D5/00A61K36/30A61K9/00A61P17/02A61P35/00A61P39/06
Inventor 朱利民韩洁
Owner DONGHUA UNIV
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