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Use of wild camellia oil in preventing and treating light beam type dermatosis

A technology of wild camellia oil and skin diseases, which is applied in the application field of wild camellia oil in the prevention and treatment of actinic skin diseases, and can solve the problems of unrecorded clinical curative effects of various diseases

Inactive Publication Date: 2009-02-11
江西金海棠药用油有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] Although, the current "Pharmacopoeia of the People's Republic of China" only records camellia oil as the raw material of tea oil for injection or the base of ointment, and does not record its clinical curative effect on various diseases; but the application of camellia oil in various diseases Research is not over

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Embodiment 1: the protective effect of wild camellia oil on long-wave ultraviolet rays

[0017] 1 Materials and methods

[0018] 1.1 Grouping of experimental animals 24 SD rats, weighing about 120g, half male and half male, were shaved on the back with a clipper before UVA irradiation, once every 2 days. The experimental animals were divided into three groups: ①Non-ultraviolet irradiation group (control group): No treatment factor was applied, only synchronous feeding. ②UVA irradiation group: UVA irradiation only. ③Test group: apply Golden Begonia brand wild camellia oil on the irradiated part + UVA irradiation.

[0019] 1.2 Light source and irradiation method Use 5 parallel UVA lamp tubes, 90% of the spectrum of the lamp tubes is concentrated at 320-400nm, after the UV lamp tube is preheated and stabilized, it is measured with a UVA radiation meter, and the intensity is 4.5mW / cm 2 . Preheat the UVA lamp tube, and irradiate the lamp tube at a distance of 40cm from t...

Embodiment 2

[0030] Embodiment 2: the protective effect of wild camellia oil on medium wave ultraviolet rays

[0031] 1 Materials and methods

[0032] 1.1 Experimental animals White guinea pig, male, body weight (450±50) g;

[0033] 1.2 Establishment of UVB oxidative damage model Guinea pigs were adaptively fed for 5 days, and randomly divided into normal group, UVB irradiation group, matrix blank group and treatment group, 5 in each group. The right back of the guinea pig is mechanically depilated, the exposed skin is 5cm×5cm, the UVB light source is turned on, preheated for 5 minutes, and the radiant energy at 10cm measured by the ultraviolet radiation illuminance meter is 1.4μW·cm -2 . Expose the skin on the right side of the guinea pig, place it 10cm under the UVB light source, and the initial dose is 0.168J·cm -2 , Depending on the number of erythema, the dose is gradually strengthened. After irradiation, wild camellia oil was applied to the exposed areas of the skin. Continuous ...

Embodiment 3

[0046] Embodiment 3: the antagonism effect of wild camellia oil on skin photosensitivity

[0047] 1 Materials and methods

[0048] 1.1 Kunming mice, weighing 18-22g, half male and half male.

[0049] 1.2 Anti-photosensitivity test The mice were divided into three groups: a group of iv photosensitizer HpD (10mg / kg); a group of iv photosensitizer HpD (10mg / kg) and wild camellia oil, and a group of iv saline as control. The animals were immobilized and the back hair was clipped. Under the 80W fluorescent lamp for 4 hours, the ear and back skin of mice treated with HpD+ light (photosensitization) were obviously congested and swollen. The mice were sacrificed, and circular skin slices of a certain diameter were taken from both ears and the back, and the ear weight, skin flap and body weight were accurately weighed, and the ear index and skin index were calculated.

[0050] 1.3 PGE in skin 1 Determination of content The mice that were administered into groups and illuminated acc...

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Abstract

The invention relates to the application of wild camellia oil to prevent and cure actinic dermatitis, wherein, the wild camellia oil origins from mature seeds of theaceae plants. The prevention of the actinic dermatitis is to coat the light incident positions with the wild camellia oil, with a coating quantity of 2-3MuL / cm <2>; the curing of the actinic dermatitis such as solar dermatitis is to coat burnt positions with the wild camellia oil once every 2 hours with a coating quantity of 2-3MuL / cm <2> and have the coated position exposed. After being externally coated, the wild camellia oil easily combines with the surface of injured tissues and forms a protective barrier, thereby reducing external pessimal stimulation to the injured surfaces, relieving pain, and being beneficial to the generation of epithelial cells of the injured surfaces, the growth of granulation tissue and the healing of the injured surface. The invention fully and reasonably utilizes natural resources and improves the health-care level and life quality of human beings.

Description

technical field [0001] The invention relates to the application of wild camellia oil in the preparation for preventing and treating actinic skin diseases such as solar dermatitis. Background technique [0002] Ultraviolet rays in sunlight are more harmful to the surface of the human body, and the longer the wavelength, the stronger the penetrating ability; medium-wave ultraviolet rays are mainly absorbed by the epidermis and damage the epidermis; long-wave ultraviolet rays can reach the upper part of the dermis and can act on blood vessels and other tissues. [0003] There are two types of abnormal reactions caused by sunlight acting on the human body: phototoxicity and allergic reaction. [0004] A phototoxic reaction is a non-immune reaction that can happen to anyone. Partially exposed to strong sunlight will produce skin lesions such as erythema, edema, and blisters in a short period of time; repeated exposure to strong sunlight for a long time can cause skin wrinkles, s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/82A61P17/16
Inventor 范友灵朱少新万金梅
Owner 江西金海棠药用油有限公司
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