Drug-loaded polyelectrolyte capsules in response to phosphatase concentration and preparation method thereof

A polyelectrolyte and phosphatase technology, applied in capsule delivery, pharmaceutical formulations, medical preparations of non-active ingredients, etc.
CN101396351AInactive Publication Date: 2009-04-01RUIJIN HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
RUIJIN HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
Publication Date
2009-04-01
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to an intelligent drug controlled release system which is formed by adding organic phosphate component into polyelectrolyte capsule wall. The intelligent drug controlled release system has the advantages that the component of the polyelectrolyte capsule can respond to the concentration of acid phosphatase in the blood serum of a patient with tumour and influence the permeability of the capsule wall to achieve the effect of releasing drugs intelligently; and as a tumour marker, the acid phosphatase is used for observing the development and treatment effect of the tumour in the clinical work. The vitality increase of removed blood serum of the patient with prostate cancer can be dozens of times normal value, and the acid phosphatase in the blood serum of the patients with stomach cancer, colon cancer, breast cancer, hypothyroid cancer, kidney cancer, ovary cancer, malignant lymphogranulomatosis and multiple myeloma can also have moderate increase, therefore, a drug loaded polyelectrolyte capsule intelligent drug controlled release system with the acid phosphatase as the response can process drug controlled release treatment on various tumors. The intelligent drug controlled release system uses the tumour marker phosphatase as the drug controlled release condition, so the intelligent drug controlled release system has better practical application meaning.
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Description

technical field

[0001] The invention relates to the field of pharmacy, in particular to a drug-loaded polyelectrolyte capsule capable of responding to the concentration of phosphatase and a preparation method thereof. Background technique

[0002] As we all know, tumor has become a major malignant disease that endangers human beings all over the world. Chemotherapy is one of the methods to treat tumors. Many clinical chemotherapeutic drugs, such as doxorubicin, have a broad anticancer spectrum and significant clinical efficacy, and can treat a variety of tumors. However, due to their severe cardiotoxicity, bone marrow suppression and other side effects, their clinical application is limited. application.

[0003] In the past, drug release systems were mostly designed as ring-opening systems. Drugs can only be released in a predetermined program and are usually not affected by changes in the external environment. In recent years, we have begun to study the use of a closed-...

Claims

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