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Pharmaceutical composition for treating chronic atrophic gastritis

A technology of atrophic gastritis and composition, applied in the field of pharmaceutical composition, can solve problems such as large dosage of decoction, low patient compliance, and insignificant curative effect

Active Publication Date: 2010-12-15
CHIATAI QINGCHUNBAO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the method of invigorating the spleen and harmonizing the stomach, warming the middle and replenishing qi is commonly used. Xiangsha Liujunzi Decoction (ginseng, Atractylodes macrocephala, licorice, tangerine peel, pinellia, amomum, woody fragrance), Huangqi Jianzhong decoction (maltose, cinnamon sticks, peony, ginger , Jujube, Astragalus, Radix Glycyrrhizae), Sini Powder, Citron Zhizhu Decoction and other traditional Chinese medicine decoctions, Chinese patent medicine preparations such as Jiawei Zuojin Pills, Xiangsha Yangwei Pills, etc. stagnation, the curative effect is not significant, there are few drugs for the treatment of chronic atrophic gastritis, the dosage of decoction is large, and the patient's compliance is low. It is urgent to take and carry the dosage form in clinical practice, which can improve the clinical research and treatment of CAG to a level. new level

Method used

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  • Pharmaceutical composition for treating chronic atrophic gastritis
  • Pharmaceutical composition for treating chronic atrophic gastritis
  • Pharmaceutical composition for treating chronic atrophic gastritis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Example 1: Take 6kg Sunburn Astragalus, 9kg Codonopsis Codonopsis, 3kg Tangerine Peel, 9kg Rhizoma Cyperi, 6kg Radix Paeoniae Alba, 6kg Chinese Yam, 2kg Black Plum, and 4kg Licorice, wash the above eight flavors, extract volatile oil from Tangerine Peel, and fry the remaining seven flavors with water Boil twice, 3 hours for the first time, and 2 hours for the second time (during the second decoction, add the dried tangerine peel residue after extracting the volatile oil), combine the decoction liquid, and filter. The filtrate was left to settle, and the supernatant was concentrated to a concentrated solution with a relative density of 1.05 to 1.10 (85°C thermal measurement), the concentrated solution was left to stand for more than 8 hours, the supernatant was filtered, and the filtrate was concentrated to a relative density of 1.14 to 1.16 ( Determination after diluting 2 times) clear ointment. Take 1 part of clear paste, add 1.75 parts of sucrose powder, 1.75 parts of...

Embodiment 2

[0027] Example 2: Take 8 kg of Astragalus root, 6 kg of Codonopsis pilosula, 4 kg of tangerine peel, 6 kg of Cyperus cyperi, 12 kg of white peony root, 12 kg of Chinese yam, 5 kg of black plum, and 6 kg of licorice. Add water and decoct twice, the first time for 3 hours, and the second time for 2 hours (during the second decoction, add the residue of tangerine peel after extracting the volatile oil), combine the decoction liquid, and filter. The filtrate was left to settle, and the supernatant was concentrated to a relative density of 1.08-1.12 (by heat measurement at 85°C), and dextrin was added to obtain a concentrated solution with a relative density of 1.14-1.18 (by heat measurement at 85°C). The concentrated solution is spray-dried to make granules, then sprayed into tangerine peel volatile oil, and mixed evenly to obtain granules.

Embodiment 3

[0028] Example 3: Take 6 kg of Astragalus membranaceus, 5 kg of Codonopsis pilosula, 5 kg of tangerine peel, 6 kg of Cyperus cyperi, 6 kg of white peony, 6 kg of Chinese yam, 2 kg of black plum, and 4 kg of licorice, wash the above eight medicinal materials, extract volatile oil from the tangerine peel, and the remaining seven flavors Add water and decoct twice, the first time for 2 hours, and the second time for 2 hours (during the second decoction, the residue of tangerine peel after extracting the volatile oil is added), combine the decoction liquid, and filter. The filtrate was left to settle, and the supernatant was concentrated to a concentrated solution with a relative density of 1.00 to 1.10 (85°C thermal measurement), added volatile oil of dried orange peel, 10ml of essence, appropriate amount of preservative, 8.5kg of sucrose, mixed well, and added distilled water to make the whole amount into 30L, filter, fill, sterilize, and get ready.

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Abstract

The invention provides a medicine composition for treating chronic atrophic gastritis, which has the advantages of obvious curative effect and convenient carrying. The medicine composition can not only improve various clinical symptoms of the chronic atrophic gastritis, but also improve intestinal metaplasia and heterotypic hyperplasia accompanying the chronic atrophic gastritis, thereby realizing stomach cancer prevention by the medicine. The medicine composition is prepared by the extracts of roasted milkvetch root, radix codonopsis pilosulae, dried orange peel, nutagrass flatsedge rhizome,white peony root, Chinese yam, black plum and liquorice; the preparation process is simple and is suitable for mass production; the clinical tests show that the preparation 'stomach nourishing granules' prepared by the technical proposal can fully improve various symptoms of the chronic atrophic gastritis, achieve the aim of clinical curing, and has more stable efficacies in particular to the chronic atrophic gastritis caused by weakness of the spleen and the stomach or weakness of the spleen and the stomach and qi stasis.

Description

technical field [0001] The invention relates to a pharmaceutical composition, in particular to a pharmaceutical composition for treating chronic atrophic gastritis. Background technique [0002] Chronic atrophic gastritis (CAG) is a chronic disease characterized by atrophy of the gastric mucosal epithelium and glands, thinning of the mucosa, thickening of the muscularis mucosa, and often accompanied by intestinal glandular metaplasia and atypical hyperplasia. The clinical manifestations are mostly fullness in the epigastric cavity, pain, loss of appetite, belching, pantothenic acid, etc., which belong to the category of "gastric fullness" and "gastralgia" in Chinese medicine. CAG is listed as a precancerous disease or precancerous state of gastric cancer, while intestinal metaplasia and dysplasia associated with it are called precancerous lesions of gastric cancer. Effective prevention and treatment of chronic atrophic gastritis and its associated symptoms can prevent the o...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8945A61K9/00A61K9/16A61P1/04
Inventor 冯鹤王木兰张建兵沈培强张晓丽
Owner CHIATAI QINGCHUNBAO PHARMA
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