5-methyl morpholine-3-amino-2-oxazolidinone derivative hapten, antigen and antibody, and application thereof

A technology of methylmorpholine and oxazolidinone, applied in the field of immunology, to achieve high titer, high sensitivity and stable results
CN101407501BInactive Publication Date: 2012-05-09SOUTH CHINA AGRI UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SOUTH CHINA AGRI UNIV
Publication Date
2012-05-09
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a method for preparing hapten, antigen and antibody of 5-methylmorpholine-3-amino-2-oxazolidone derivatives. The hapten obtained by designing and preparing the 5-methylmorpholine-3-amino-2-oxazolidone derivatives is similar to counterparts of the 5-methylmorpholine-3-amino-2-oxazolidone derivatives in molecular structure, spatial chemistry and electron distribution. The linking arm in the hapten structure is not easy to induce and generate 'arm antibody', and the organism is easier to identify as a saturate carbon chain of a certain length is used; the antigen which isprepared by hapten cross coupling carrier protein ensures the organism to produce the antibody of high tilter and good specificity in accordance with the 5-methylmorpholine-3-amino-2-oxazolidone derivatives; and the antibody is used for detecting the residue of 5-methylmorpholine-3-amino-2-oxazolidone in animal source food with quick response and stable result.
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Description

technical field

[0001] The invention belongs to the technical field of immunology, and in particular relates to 5-methylmorpholine-3-amino-2-oxazolidinone derivative hapten, antigen, antibody and preparation method thereof, and prepared 5-methylmorpholine -3-amino-2-oxazolidinone derivative hapten, antigen and antibody and application of antibody. Background technique

[0002] Furaltadone, a nitrofuran drug, is a broad-spectrum antibiotic that has certain antibacterial effects on both Gram-positive and Gram-negative bacteria. However, relevant studies have proved that nitrofuran drugs and their metabolites have considerable toxicity, teratogenic side effects, and can induce cancer, which has attracted people's attention. In July 1990, the European Union promulgated Regulation 2377 / 90 / EEC, which listed nitrofuran drugs and their metabolites as Class A prohibited drugs, and stipulated that the detection limit of their residues in food of animal origin was 1.0 μg / kg. Since 1...

Claims

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