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Creat extract and medical use thereof

A technology of Andrographis paniculata and extracts, which is applied in the field of medicine and can solve problems such as large side effects and insignificant therapeutic effects

Active Publication Date: 2009-05-06
NUTRITION SCI PARTNERS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

For example, 5-aminosalicylic acid, a TNFα inhibitor, has been used to treat ulcerative colitis (Therapeutic Immunology Ed. Austen, K F., Blackwell Publishing, 2001, 159-167) However, all current drugs have therapeutic effects Disadvantages of inconspicuous and large side effects

Method used

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  • Creat extract and medical use thereof

Examples

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Effect test

preparation example Construction

[0110] There are many preparation techniques for inhalation preparations. This dosage form can be a saline solution of the drug, and benzyl alcohol is used as a preservative, and an absorption enhancer is used to improve bioavailability. can be found in .

[0111]Preparations for topical administration may be oils, creams, lotions, ointments, etc., and the base used may be vegetable oil, mineral oil, white mineral fat (such as white soft paraffin), branched chain fat or oil, animal fat, High molecular weight alcohols (greater than 12 carbons). The best matrix is ​​one in which the drug can dissolve. Emulsifiers, stabilizers, humectants, antioxidants and color and taste regulators can be added as needed. Furthermore, transdermal absorption enhancers may be used in topical formulations, examples of which are given in US Pat. Nos. 3,989,816 and 4,444,762. A very suitable formulation for topical administration is a cream consisting of mineral oil, self-emulsifying beeswax and w...

Embodiment 1

[0115] Example 1 Preparation of andrographis paniculata extract

[0116] Soak Andrographis paniculata branch and leaf powder (350kg) with 90% ethanol (2100kg), reflux at 75-80°C for 2 hours, extract the ethanol solution, the residue is used for leaching again, mix the ethanol solution, filter and concentrate to obtain a density of 1.00-1.10g / ml liquid extract.

[0117] Get a small amount of fluid extract and use HPLC analysis after drying, the result dry extract contains total andrographolide (14.8% accounts for dry extract ratio), total polysaccharide (24.6%) and total flavonoids (12.8%). Containing andrographolide in total andrographolide accounted for 9.2% of dry extract, 14-deoxyandrographolide <0.1%, 14-deoxy-11,12-dehydroandrographolide 2.6%, and neoandrographolide 3.0%. Dextrin (0.03kg) is spray-dried after adding the liquid extract (inlet: 185-195°C; exhaust: 90-100°C), and after crushing and sieving, the Andrographis paniculata extract is packed for the preparatio...

Embodiment 2

[0120] Example 2 Mixture

[0121] Mixtures containing Andrographis paniculata extract (Table 1) were formulated to contain active ingredients in the following amounts:

[0122] Table 1

[0123] Mixture 1 mixture 2 Andrographolide (g) 50 120 14-Deoxyandrographolide (g) 30 0.5 14-Deoxy-11,12-dehydro-andrographolide

[0124] The above mixture plus some conventional auxiliary materials can be prepared into various dosage forms, such as tablets, capsules, etc., by conventional methods, and the preparation method is the same as in Example 1.

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Abstract

The invention belongs to the medicament science field and discloses an andrographis paniculata extract and a preparation method thereof. The invention also discloses a drug combination containing the andrographis paniculata extract, and the application of the andrographis paniculata extract.

Description

technical field [0001] The invention belongs to the field of medicine, and more specifically, the invention relates to an extract of Andrographis paniculata and its medical application. Background technique [0002] "Inflammatory bowel disease" is a general term for two non-specific enteritis, Crohn's disease and ulcerative colitis. [0003] Ulcerative colitis occurs in the large intestine. Inflammation and even ulceration due to lesions in the intestine. [0004] Crohn's disease occurs mainly in the end of the small intestine and part of the large intestine. Its inflammation goes deeper into the intestinal wall than ulcerative colitis. [0005] Both of the above diseases are associated with the abnormality of precursor inflammatory cytokines TNFα and IL-1. (e.g., McClane S.J. et al., Journal of Parenteral and Enteral Nutrition23, 1999.) Drugs that down-regulate precursor inflammatory cytokines have been develop. For example, 5-aminosalicylic acid, a TNFα inhibitor, has...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/19A61K9/02A61P1/00A61P1/04
Inventor 严孝强王滔马志明张维汉段继峰蔡宇
Owner NUTRITION SCI PARTNERS
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