Method for extracting admantadine

An amantadine and extraction method technology, which is applied in the extraction field of organic compounds, can solve the problems of large energy consumption, low product quality, low yield and the like, and achieves the reduction of energy consumption, production cost and simple process. Effect

Inactive Publication Date: 2009-05-13
庞明
View PDF0 Cites 5 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are several problems in the above-mentioned method for extracting amantadine by physical means: 1. the addition amount of sodium hydroxide solution is difficult to control, if the addition amount is small, amantadine cannot be completely distilled out, and the yield of reaction is low, generally at 40% — Between 50%; if the amount added is too large, foam will be generated during disti

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Method for extracting admantadine
  • Method for extracting admantadine
  • Method for extracting admantadine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0023] Add 500Kg of bromoadamantane and 180Kg of urea into the reaction kettle for amination reaction to generate amantadine containing impurities and insoluble in water. When the temperature drops to 100°C-120°C, add 950Kg of drinking water to fully Stir to separate the amantadine and the impurities bonded together, then add concentrated hydrochloric acid until the solution pH=1, the concentrated hydrochloric acid and amantadine react to generate amantadine hydrochloride C10H17N.HCl aqueous solution that can be dissolved in water, and the After amantadine hydrochloride C10H17N.HCl aqueous solution is filtered to remove water-insoluble impurities, sodium hydroxide solution is added to the solution until the solution PH=14, amantadine hydrochloride and sodium hydroxide react to form water-insoluble adamantine again Alkylamine, just filter out amantadine.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses a method for extracting amantadine, which aims to provide a method for extracting amantadine by a chemical means. The method has the advantages of simple technological process, little needed equipment and energy consumption, high yield, high purity of obtained amantadine and good quality. The invention adopts a technical proposal that after bromoadamantane and urea react to form water-insoluble amantadine, the amantadine is extracted according to the following steps: A. excessive hydrochloric acid is added to resultant, and the amantadine reacts with the hydrochloric acid to form water-soluble amantadine hydrochloride; and B. water-insoluble impurities are filtered and removed; excessive sodium hydroxide solution is added to residual solution; the amantadine hydrochloride and sodium hydroxide react to form the water-insoluble amantadine again; and the amantadine is filtered out. Due to the technical proposal of the invention, the amantadine yield of the method is higher than that of the prior process by more than 8 percent, and the purity of the obtained amantadine is more than 60 percent.

Description

technical field [0001] The present invention relates to a method for extracting organic compounds, more specifically, relates to a method for extracting amantadine. Background technique [0002] Amantadine is mainly used to manufacture an antiviral drug—amantadine hydrochloride, which is an intermediate product in the production process of the drug, and is produced using bromoadamantane and urea as raw materials. The process flow for taking amantadine is shown in Figure 1. The specific production method is: after heating the reactor to 170°C, add bromoadamantane and urea into the reactor, and the two undergo an amination reaction to form a water-insoluble The amantadine, its reaction formula is: [0003] [0004] Bromoadamantane Urea Amantadine [0005] Because the reactant contains water-insoluble impurities, the generated amantadine and water-insoluble impurities bond together to reduce its purity. In order to remove these water-insoluble impurities, after the reactio...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): C07C211/38C07C209/08
Inventor 庞明
Owner 庞明
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap