Tumor-targeted carbon nano-tube medicament carrier and preparation thereof

A carbon nanotube and tumor-targeting technology, which is applied in the direction of anti-tumor drugs, drug combinations, and pharmaceutical formulations, can solve the problems of less transport of small molecule drugs and no reports of targeted transport, and achieve low toxicity and good biological safety performance, easy preparation

Inactive Publication Date: 2009-05-20
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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Problems solved by technology

Compared with the research on the transport of biomacromolecules with carbon nanotubes, there are relatively few studies on the transport of small molecule drugs (document 7.Wu W., S.Wieckowski, et al., Targeted delivery of amphotericin B to cells by using functionalized carbonnanotubes, Angewandte Chemie-International Edition 2005, 44(39), 6358-6362), especially after combining with small molecule drugs in the form of adsorption, the research on targeted transport has not been reported at all

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  • Tumor-targeted carbon nano-tube medicament carrier and preparation thereof
  • Tumor-targeted carbon nano-tube medicament carrier and preparation thereof
  • Tumor-targeted carbon nano-tube medicament carrier and preparation thereof

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Embodiment

[0032] 1. Preparation of carbon nanotube drug delivery carrier: treat carbon nanotubes with concentrated nitric acid and concentrated sulfuric acid to form carboxyl groups on the surface to increase water solubility. Phycoerythrin-labeled P-glycoprotein antibody (Anti-P-gp-PE) is covalently bonded to the surface of oxidized carbon nanotubes. See the specific preparation route figure 1 .

[0033]1) Preparation of oxidized carbon nanotubes (o—CNT) (document 8. Pan CS, Zou HF, et. Carbon Nanotubes as Adsorbent of Solid-Phase Extraction and Matrix for Laser Desorption / Ionization Mass Spectrometry J Am Soc Mass Spectrom 2005 16: 883 —892.): The original carbon nanotube (CNT) was reacted with concentrated nitric acid and concentrated sulfuric acid (V / V=1 / 3) at 120°C for 30 minutes under the condition of stirring and refluxing. The oxidized carbon nanotube solution was diluted 10 times with water, then filtered through a 0.45um membrane and washed with water until the filtrate was ...

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Abstract

The invention relates to a nano-drug delivery carrier, in particular to a tumor-targeted carbon nanotube drug carrier and a preparation method thereof. A P-glycoprotein antibody labeled by phycoerythrin is covalently bonded on an oxidized carbon nanotube and can be taken as a delivery carrier of small molecular drugs, and the drug carrier loads small molecular drugs through the adsorption action. The drug carrier has simple preparation, and has the characteristics of target administration, controllable slow release and the overcoming of the multi-drug resistance of cells.

Description

technical field [0001] The invention relates to a nanometer drug delivery carrier, specifically a tumor-targeted carbon nanotube drug carrier and its preparation. The drug carrier is loaded with small molecule drugs in an adsorbed manner, can identify multidrug resistant cells, and can release slowly Drugs to multidrug resistant cells. It is suitable for patients with low drug efficiency due to high expression of P-glycoprotein (P-gp) clinically. Background technique [0002] Chemotherapy is currently the main method used to treat cancer, but during chemotherapy, tumor cells will produce multidrug resistance (MDR), which has become a huge obstacle to curing cancer (document 1.Higgins C.F, Multiple molecular mechanisms for multidrug resistance transporters, Nature 2007, 446(7137), 749-757.). Multidrug resistance means that in the process of killing cells with a cytotoxic agent, the cells will also develop related drug resistance to other agents whose structure is not simila...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/48A61K47/42A61K47/04A61P35/00A61K47/68
Inventor 邹汉法李瑞宾吴仁安
Owner DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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