Tumor-targeted carbon nano-tube medicament carrier and preparation thereof
A carbon nanotube and tumor-targeting technology, which is applied in the direction of anti-tumor drugs, drug combinations, and pharmaceutical formulations, can solve the problems of less transport of small molecule drugs and no reports of targeted transport, and achieve low toxicity and good biological safety performance, easy preparation
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[0032] 1. Preparation of carbon nanotube drug delivery carrier: treat carbon nanotubes with concentrated nitric acid and concentrated sulfuric acid to form carboxyl groups on the surface to increase water solubility. Phycoerythrin-labeled P-glycoprotein antibody (Anti-P-gp-PE) is covalently bonded to the surface of oxidized carbon nanotubes. See the specific preparation route figure 1 .
[0033]1) Preparation of oxidized carbon nanotubes (o—CNT) (document 8. Pan CS, Zou HF, et. Carbon Nanotubes as Adsorbent of Solid-Phase Extraction and Matrix for Laser Desorption / Ionization Mass Spectrometry J Am Soc Mass Spectrom 2005 16: 883 —892.): The original carbon nanotube (CNT) was reacted with concentrated nitric acid and concentrated sulfuric acid (V / V=1 / 3) at 120°C for 30 minutes under the condition of stirring and refluxing. The oxidized carbon nanotube solution was diluted 10 times with water, then filtered through a 0.45um membrane and washed with water until the filtrate was ...
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