Double-layer traditional Chinese medicine patch for treating oral ulcer and preparation method thereof

A technology of oral ulcer and traditional Chinese medicine, which is applied in the field of traditional Chinese medicine oral ulcer double-layer patch and its preparation. The effect of slow release, reduction of systemic side effects, and pain relief

Inactive Publication Date: 2009-06-03
TIANJIN JINGUIGU XYLITOL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, the gargle has a shorter action time; the ointment is difficult to apply to the affected area; although the film can be attached to the ulcer surface, it usually dissolves and disappears in about 5 minutes, which is not ideal yet.
Traditional Chinese medicine includes: Xileisan, Bingbosan and other powders, especially Bingbosan has a strong irritation to the wound surface and is inconvenient to use. Moreover, if it is applied to the affected area, it will quickly be lost with saliva, which limits its role.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] 1. 8 grams of Evodia rutaecarpa, 15 grams of Qingdai, 5 grams of licorice, and 10 grams of Chinese gall, decocted in water for 3 times, 2 hours each time, and concentrated the water extract to a specific gravity of 1.2-1.4, then centrifuged at a high speed; 2. Centrifuged liquid or concentrated Dried to obtain the crude extract; 3. Macroporous resin, eluted with water, concentrated after decolorization of the eluent, precipitated with 95% ethanol, placed in the refrigerator, filtered, vacuum-dried the filter cake, crushed and sieved or spray-dried to obtain off-white Extract in fine powder form.

Embodiment 2

[0041] Reflux 12 grams of Evodia rutaecarpa, 20 grams of Qingdai, 10 grams of licorice, and 15 grams of Gallnut, reflux with 75% ethanol, extract 3 times, concentrate the filtrate into an extract, add water to make the extract into a suspension, wash with macroporous resin D301 After decolorization, the eluate is concentrated, precipitated with 95% ethanol, placed in the refrigerator, filtered, and the filter cake is vacuum-dried, pulverized, sieved or spray-dried to obtain an off-white fine powder extract.

Embodiment 3

[0043] 10 grams of Evodia rutaecarpa, 150 grams of Qingdai, 8 grams of licorice, 15 grams of Chinese gall, 10 grams of Evodia, 150 grams of Qingdai, 8 grams of licorice, and 15 grams of Chinese gall, refluxed with 95% ethanol, extracted twice, concentrated the filtrate into an extract, added water Make the extract into a suspension, elute with macroporous resin D301, water, decolorize the eluent, concentrate, precipitate with 95% ethanol, place in the refrigerator, filter, vacuum dry the filter cake, crush and sieve or spray dry to obtain the White fine powder extract.

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PUM

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Abstract

The invention relates to a double-layer traditional Chinese medicine patch for treating oral ulcer, wherein, a medicine-containing adhesion layer contains 0.1-15mg of a Chinese medicine extract, carbopol, xylitol, low-substituted hydroxyproxyl cellulose and sodium carboxymethyl cellulose; a water insoluble protection layer is made from ethyl cellulose and food color; wherein, the Chinese medicine extract is made from 8-12g of evodia fruit, 15-20g of nantural oindigo, 5-10g of licorice and 10-15g of Chinese gallnut. The double-layer traditional Chinese medicine patch can adequately improve local ulcer issue, recover and heal soon to achieve the therapeutic purpose. The prepared traditional Chinese medicine is nontoxic and harmless on human body, and requires no decoction, is convenient for being taken. The patch treats both superficiality and origin of the oral ulcer, has obvious clinical curative effect and has the effective rate up to 96%.

Description

technical field [0001] The invention relates to a medicine for treating oral diseases, in particular to a traditional Chinese medicine oral ulcer double-layer patch and a preparation method thereof. technical background [0002] Recurrent oral ulceration, also known as recurrent oral ulceration, is a localized ulcer disease of oral mucosa characterized by periodic recurrence. It is characterized by recurrent attacks, unbearable burning pain, and can cause various complications at the same time. With the prolongation of the course of the disease, many patients have enlarged ulcer area and number, aggravated pain, prolonged healing period, and shortened interval, which affect eating and speaking. Although there are many treatments for oral ulcers, they are basically symptomatic treatments. The purpose is mainly to relieve pain or reduce the number of recurrences, but the recurrences cannot be fully controlled, so prevention of this disease is particularly important. The theo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/754A61K9/24A61K47/38A61P1/02A61K35/64
Inventor 马永华邱洪江
Owner TIANJIN JINGUIGU XYLITOL
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