Polyurethane material with anti-protein adsorption and antibacterial functions

A polyurethane material and anti-protein adsorption technology, applied in the fields of biomedical materials and polymer chemistry, can solve problems such as necrosis and repeated infection of tissue, and achieve the effects of easy control, low cost and simple preparation method

Inactive Publication Date: 2009-06-24
WUHAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In addition, the application of biological materials and artificial devices is becoming more and more widespread, but the bacterial infection caused by the use process leads to many serious consequences, which can cause adverse reactions such as repeated infection and tissue necrosis, which cannot be ignored

Method used

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  • Polyurethane material with anti-protein adsorption and antibacterial functions
  • Polyurethane material with anti-protein adsorption and antibacterial functions
  • Polyurethane material with anti-protein adsorption and antibacterial functions

Examples

Experimental program
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preparation example Construction

[0020] (1) Preparation of CP:

[0021] On an ice bath, first disperse 0.6-1.2g of Poria cocos sclerotia polysaccharide in 10-20mL of a mixture I consisting of 20% NaOH and 25-50mL of isopropanol by mass percentage, and stir for 3-4 hours to form a uniform suspension for reaction system. Then 5.25-10.50 g of chloroacetic acid was dissolved in 25-50 mL of isopropanol, and mixed with another 10-20 mL of 20% NaOH in a mass ratio to form a mixed solution II. Slowly add half of the above mixed solution II into the reaction system dropwise, stir and react at room temperature for 3-4 hours, then raise the temperature of the reaction solution to 60-65°C and continue stirring for 30-40 minutes. Then the other half of the mixture II was slowly added dropwise, and the reaction was continued for 40-60 min at 60-65°C. After stopping the reaction, cool to room temperature, and then adjust the pH value of the reaction solution to 6 with 0.3-0.5M HCl. The above reaction solution was dialyze...

Embodiment 1

[0033] On an ice bath, first disperse 0.6 g of Sclerotinia polysaccharide in 10 mL of a mixture I consisting of 20% NaOH and 25 mL of isopropanol, and stir for 3 hours to form a uniform suspension reaction system. Then 5.25 g of chloroacetic acid was dissolved in 25 mL of isopropanol, and mixed with another 10 mL of 20% NaOH in a mass ratio to form a mixed solution II. First half of the above mixed solution II was slowly added dropwise to the reaction system, stirred and reacted at room temperature for 3 hours, and then the reaction solution was heated to 60° C. and continued to stir for 40 minutes. Then the other half of the mixture II was slowly added dropwise, and the reaction was continued for 60 min at 60°C. After stopping the reaction, cool to room temperature, and then adjust the pH value of the reaction solution to 6 with 0.5M HCl. The above reaction solution was dialyzed with running water for 3 days and distilled water for 3 days, concentrated by rotary evaporation,...

Embodiment 2

[0036] On an ice bath, first disperse 1.2 g of Sclerotinia polysaccharide in 20 mL of a mixture I consisting of 20% NaOH and 50 mL of isopropanol by mass percentage, and stir for 4 hours to form a uniform suspension reaction system. Then 10.50 g of chloroacetic acid was dissolved in 50 mL of isopropanol, and mixed with another 20 mL of 20% NaOH in a mass ratio to form a mixed solution II. Slowly add half of the above mixed solution II into the reaction system dropwise, stir the reaction at room temperature for 3 hours, then raise the temperature of the reaction solution to 65° C. and continue stirring for 30 minutes. Then the other half of the mixture II was slowly added dropwise, and the reaction was continued for 40 min at 65°C. After stopping the reaction, cool to room temperature, and then adjust the pH value of the reaction solution to 6 with 0.3M HCl. The above reaction solution was dialyzed with running water for 4 days and distilled water for 3 days, concentrated by r...

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Abstract

The invention discloses a polyurethane material with a protein adsorption resistant function and an antibacterial function. The polyurethane material consists of a modification layer and a base layer; the base layer is composed of a common commercial polyurethane material, the modification layer is formed on the surface of the base layer by a chemical modification method, and the modification layer contains fungi carboxymethyl-pachymaran derivative CP which is bonded with the polyurethane base layer by a covalent bond. The preparation of the polyurethane material comprises the following steps: preparing the fungi carboxymethyl-pachymaran derivative CP; functionalizing the surface of a PU material by MDI; grafting an amino on the surface of the PU material; and grafting the fungi carboxymethyl-pachymarand derivative CP on the surface of the PU material. The material has better hydrophilicity and protein adsorption resistant function, as well as the antibacterial function of inhibiting bacillus pyocyaneus, thus the material has the use as a biomedical material of an artificial organs and a part implanted into human body. The material has simple and easily controlled preparation method and low cost.

Description

technical field [0001] The invention relates to the fields of biomedical materials and macromolecular chemistry, in particular to a polyurethane material with anti-protein adsorption and antibacterial functions and its preparation and application. Background technique [0002] Polyurethane (PU) materials have great application value in the manufacture of various devices implanted in the human body, such as artificial heart valves, artificial dialysis membranes, artificial blood vessels and other medical polymer materials. However, the biological properties of common polyurethane materials are still unsatisfactory, which restricts their clinical application. The surface of medical polymer materials is one of the key factors affecting their biocompatibility, and the surface modification and design of materials are also important means to change the biocompatibility of materials. The polysaccharide-protein complex structure on the cell membrane surface is an important structur...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J7/12C08L75/04A61L27/20
Inventor 王艺峰徐伟陈红金华芳袁琳
Owner WUHAN UNIV OF TECH
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