Polyurethane material with anti-protein adsorption and antibacterial functions

A polyurethane material and anti-protein adsorption technology, applied in the fields of biomedical materials and polymer chemistry, can solve problems such as necrosis and repeated infection of tissue, and achieve the effects of easy control, low cost and simple preparation method
CN101463139AInactive Publication Date: 2009-06-24WUHAN UNIV OF TECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
WUHAN UNIV OF TECH
Publication Date
2009-06-24
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a polyurethane material with a protein adsorption resistant function and an antibacterial function. The polyurethane material consists of a modification layer and a base layer; the base layer is composed of a common commercial polyurethane material, the modification layer is formed on the surface of the base layer by a chemical modification method, and the modification layer contains fungi carboxymethyl-pachymaran derivative CP which is bonded with the polyurethane base layer by a covalent bond. The preparation of the polyurethane material comprises the following steps: preparing the fungi carboxymethyl-pachymaran derivative CP; functionalizing the surface of a PU material by MDI; grafting an amino on the surface of the PU material; and grafting the fungi carboxymethyl-pachymarand derivative CP on the surface of the PU material. The material has better hydrophilicity and protein adsorption resistant function, as well as the antibacterial function of inhibiting bacillus pyocyaneus, thus the material has the use as a biomedical material of an artificial organs and a part implanted into human body. The material has simple and easily controlled preparation method and low cost.
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Description

technical field

[0001] The invention relates to the fields of biomedical materials and macromolecular chemistry, in particular to a polyurethane material with anti-protein adsorption and antibacterial functions and its preparation and application. Background technique

[0002] Polyurethane (PU) materials have great application value in the manufacture of various devices implanted in the human body, such as artificial heart valves, artificial dialysis membranes, artificial blood vessels and other medical polymer materials. However, the biological properties of common polyurethane materials are still unsatisfactory, which restricts their clinical application. The surface of medical polymer materials is one of the key factors affecting their biocompatibility, and the surface modification and design of materials are also important means to change the biocompatibility of materials. The polysaccharide-protein complex structure on the cell membrane surface is an important structur...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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