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Low-sodium peritoneal dialysis liquid

A technology of peritoneal dialysis solution and solution, which is applied in the field of peritoneal dialysis solution, can solve the problems of increasing the difficulty of preparation, affecting the expansion and promotion of clinical application range, increasing costs, etc., and achieves the advantages of expansion and popularization, pollution reduction and cost reduction Effect

Inactive Publication Date: 2009-07-22
CHENGDU QINGSHAN LIKANG PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

When preparing this low-sodium peritoneal dialysis solution containing bicarbonate ions, ordinary membrane materials cannot be used but special membrane materials must be used to solve the pH stability problem caused by the decomposition of bicarbonate ions, thus increasing the preparation time. The difficulty increases the cost and affects the further expansion and promotion of the scope of clinical application

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Put 15g of glucose, 5.05g of sodium chloride, 0.26g of calcium chloride, 0.051g of magnesium chloride, and 4.48g of sodium lactate into the preparation tank. After stirring and dissolving, add 1g of activated carbon, boil and absorb for about 10 minutes, filter for decarburization, cool, and adjust When the pH value reaches 4.5-7.0, add water for injection to the full amount (1000ml, the same below), fill in a dialysate bag, and sterilize at 115°C for 30 minutes to obtain the finished low-sodium peritoneal dialysate.

Embodiment 2

[0020] Put 12.5g of mannitol, 5.10g of sodium chloride, 0.26g of calcium chloride, 0.071g of magnesium chloride, and 4.48g of sodium lactate into the preparation tank. After stirring and dissolving, add 1.5g of activated carbon, boil and absorb for about 10 minutes, then filter and decarburize. Cool, adjust the pH value to 4.5-7.0, add water for injection to the full amount, fill it in a dialysate bag, and sterilize at 121°C for 12 minutes to obtain the finished low-sodium peritoneal dialysate.

Embodiment 3

[0022] Put 4.95g of sodium chloride, 0.26g of calcium chloride, 0.15g of magnesium chloride, and 5.00g of sodium lactate into the preparation tank, stir and dissolve, add 1.0g of activated carbon, boil and absorb for about 15 minutes, filter for decarburization, and cool for later use; Add 3.8g of prepared amino acid into the preparation tank, fill it with nitrogen for protection, keep boiling slightly for 15 minutes, filter, mix the electrolyte solution, adjust the pH value to 4.5-7.0, add water for injection to the full amount, fill it in the dialysate bag, Sterilize at 121°C for 12 minutes to obtain the finished low-sodium peritoneal dialysate.

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PUM

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Abstract

The invention discloses a low-sodium peritoneal dialysis solution. The solution does not contain bicarbonate ions, and components of the solution calculated as mmol / L comprise the following: 124 to 128 mmol / L of sodium ions, 1 to 2 mmol / L of calcium ions, 0.2 to 0.8 mmol / L of magnesium ions, 90 to 110 mmol / L of chloride ions, 37 to 47 mmol / L of lactate ions, and a corresponding isotonic agent. The low-sodium peritoneal dialysis solution, during the preparation, overcomes the defect that a special membrane material must be used in order to solve the stability problem of producing pH by decomposing bicarbonate radicals, reduces the cost, and is favorable for further expansion and popularization of clinical application.

Description

technical field [0001] The present invention relates to a low sodium peritoneal dialysis solution for medical use. Background technique [0002] Peritoneal dialysis is one of the important methods of renal replacement therapy. At present, the proportion of clinical application is increasing, which reduces the burden and pain for the majority of patients with kidney disease and improves the quality of life. However, a large number of clinical studies have gradually shown that decreased water and sodium clearance, increased volume overload and excessive water and salt in peritoneal dialysis patients are the main causes of hypertension in peritoneal dialysis patients, and the resulting cardiovascular complications have become peritoneal dialysis patients. One of the most common causes of high withdrawal rates from long-term dialysis treatment and high rates of cardiovascular events and mortality. There is increasing awareness of the importance of maintaining good volume status...

Claims

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Application Information

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IPC IPC(8): A61K33/14A61P7/08A61K31/045A61K31/191A61K31/195A61K31/7004A61K31/721A61K31/716A61K31/718A61K33/06
Inventor 欧苏崔盛
Owner CHENGDU QINGSHAN LIKANG PHARMA CO LTD
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