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Prophylactic or therapeutic agent for viral disease

A viral disease and therapeutic agent technology, applied in the field of viral disease prevention or therapeutic agent, can solve problems such as no combination effect

Inactive Publication Date: 2009-07-22
MEIJI SEIKA KAISHA LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, so far, there are no studies on the effect of its combination with other drugs

Method used

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  • Prophylactic or therapeutic agent for viral disease
  • Prophylactic or therapeutic agent for viral disease
  • Prophylactic or therapeutic agent for viral disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] Example 1: Confirmation of HCV Proliferation Inhibitory Effect of Combined Use of 22β-Methoxyolean-12-ene-3β, 24(4β)-diol and Interferon

[0059] In this example, the preventive or therapeutic agent of the present invention was evaluated using the full-genome HCV replication model described in Non-Patent Document 6.

[0060] That is, a plasmid (pT7-f1HCV-Rz) having a T7 promoter on the 5' side of the cDNA and a ribozyme gene of T7 hepatitis D virus on the 3' side of the cDNA was prepared; wherein the cDNA from hepatitis C virus (HCV) H77 strain of genotype 1a that is infectious and shown to be refractory to interferon therapy [GenBank AF011751; Yanagi, M., Purcell, R.H., Emerson, S.U., Bukh, J.Proc. Natl.Acad.Sci.U.S.A.94(16), 8738-8743(1997)] full-length clone was prepared. The above-mentioned plasmid pT7-flHCV-Rz was transfected (3 μg / well) into HepG2 cells (resource number: JCRB1054) seeded in a 6-well plate, and after 24 hours, it was infected with a recombinant ad...

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Abstract

A prophylactic or therapeutic agent for a viral disease, comprising a combination of 22beta-methoxyolean-12-ene-3beta,24(4beta)-diol and an interferon as active ingredients. The prophylactic or therapeutic agent can exert a high therapeutic effect, because 22beta-methoxyolean-12-ene-3beta,24(4beta)-diol and an interferon are administered in combination.

Description

technical field [0001] The present invention relates to a preventive or therapeutic agent for viral diseases, which uses 22β-methoxyolean-12-ene-3β, 24(4β)-diol (22β -Metokisiorean-12-ェン-3β, 24(4β)-gio-ru) and interferon. Background technique [0002] According to statistics, about 1.5 million to 2 million people are persistently infected with hepatitis C virus (HCV) in Japan, and most of them show symptoms of chronic hepatitis (see Non-Patent Document 1). In the case of hepatitis B, many cases of progression to liver cancer without going through chronic hepatitis have also been found. On the other hand, through liver tissue observation, it can be known that 80-90% of HCV-infected patients are chronic liver diseases; Document 2). HCV infection has become a major medical issue worldwide. [0003] It is known that interferon (IFN) is a highly homospecific protein family that can hinder virus replication and cell proliferation, and regulate immune response. There are 4 type...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/21A61K31/56A61P1/16A61P31/12A61P31/14A61P35/00A61P43/00
CPCA61K38/21A61K31/075A61P1/16A61P31/12A61P31/14A61P35/00A61P43/00A61K2300/00A61K31/56
Inventor 日浅阳一葛原博幸
Owner MEIJI SEIKA KAISHA LTD
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