Use of tetrahydropyridines in preparing medicine for treating oerophthalma

A technology for tetrahydropyrimidine and dry eye syndrome, which is applied in the application field of tetrahydropyrimidine in the preparation of medicaments for treating dry eye syndrome, and can solve the problems of dry eye syndrome without tetrahydropyrimidine, fog vision and poor compliance.

Inactive Publication Date: 2009-07-29
SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, it is also possible to add oil ingredients to the eyes to replenish the oil ingredients, but there will be problems with fogging and poor flexibility
At present, there are no relevant studies and reports on the use of ectoine in the treatment of dry eye syndrome

Method used

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  • Use of tetrahydropyridines in preparing medicine for treating oerophthalma
  • Use of tetrahydropyridines in preparing medicine for treating oerophthalma
  • Use of tetrahydropyridines in preparing medicine for treating oerophthalma

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Ectrahydropyrimidine 2.0g

[0016] Carbomer-940 10g

[0017] Benzalkonium Bromide 1.0g

[0018]

[0019] Sterile water for injections up to 1000ml

[0020] Preparation Process:

[0021] Take 10 g of Carbomer-940, add water to make it swell, and adjust the pH value to neutral with phosphate buffer to obtain a matrix. Separately take 2.0 g of ectoine and 1.0 g of benzalkonium bromide, add water to dissolve, slowly add to the above matrix, stir evenly, add water to 1000 ml, and vacuum degas to obtain a clear and transparent ophthalmic gel. Sterilize at 100°C for 30 minutes to obtain ectoine ophthalmic gel.

Embodiment 2

[0023] Ectrahydropyrimidine 2.0g

[0024] Carbomer 974P 3.0g

[0025] Poloxamer 407 14g

[0026] Benzalkonium Bromide 1.0g

[0027] Sodium chloride 8.5g

[0028]

[0029] Sterile water for injections up to 1000ml

[0030] Preparation Process:

[0031] Take carbomer 974P 3.0g, poloxamer 407 14g, add water to swell, use phosphate buffer to adjust the pH value to 6.0-8.0, take another ectoine 2.0g, benzalkonium bromide 1.0g, sodium chloride 8.5g Add water to dissolve, slowly add to the above matrix, stir evenly, add water to 1000ml, and vacuum degas to obtain a clear and transparent ophthalmic gel. Sterilize at 100°C for 30 minutes to obtain ectoine ophthalmic gel.

Embodiment 3

[0033] Ectrahydropyrimidine 3.0g

[0034] Cellulose acetate 4.0g

[0035] Benzalkonium Chloride 1.0g

[0036] Boric acid 2.0g

[0037]

[0038] Sterile water for injections up to 1000ml

[0039] Take 4.0g of cellulose acetate and add water to swell overnight, add 2.0g of boric acid and stir evenly to make a gel matrix, and take another 2.0g of ectoine and 1.0g of benzalkonium chloride to dissolve in water, slowly add to the above matrix, and stir evenly , add water to 1000ml, sterilize by autoclaving, and pack separately to obtain ectoine ophthalmic gel.

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PUM

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Abstract

The invention discloses novel application for Ectoine, namely application of the Ectoine in preparing medicines of treating xerophthalmia. The effective dosage range of the Ectoine is 0.1 to 100 mg / kg of body weight, preferably 8 to 50 mg / kg of the body weight. When in use, the Ectoine can be used independently, or can be combined with medically and pharmaceutically acceptable carriers for use. The inventor of the application makes related experimental research; and the experiment proves that the Ectoine can effectively protect the stability of a tear film, maintain normal tear secretion, and reduce the water evaporation of cornea / conjunctiva, thereby relieving and treating the xerophthalmia.

Description

technical field [0001] The invention relates to the application of ectoine in the preparation of medicine for treating dry eye syndrome. Background technique [0002] Dry eye is a condition in which microscopic scars appear on the surface of the eye due to a decrease in tears or a decrease in the function of the lacrimal glands. The main symptoms include: dryness, foreign body sensation, burning sensation, itching, red eyes, photophobia, blurred vision, vision fluctuations and visual fatigue, intolerance to the environment with smoke and dust. Statistics have found that dry eye syndrome occurs more frequently in industries that require high concentration, such as computer workers, office workers, and drivers. Especially white-collar workers who work in a central air-conditioned environment have a higher incidence of the disease. Staying in an air-conditioned environment for a long time will cause excessive evaporation of eye moisture, which will cause eye dryness. In addit...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/505A61P27/02A61K9/00
Inventor 厉保秋
Owner SHANDONG UNIV
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