Hydrophobia, tetanus double-titer human immunoglobulin and preparation method thereof

A technology of human immunoglobulin and immunoglobulin, applied in antiviral agents, antibacterial drugs, antibodies, etc., can solve the problems of inconvenient clinical use, single potency, high cost, etc., and achieve simple and convenient use, low preparation cost, The effect of simple preparation method

Inactive Publication Date: 2009-08-12
SHANXI KANGBAO BIOLOGICAL PROD
View PDF0 Cites 6 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the rabies immunoglobulin and tetanus human immunoglobulin used clinically in our country are both of sin

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0017] Example 1

[0018] 1. Immunization of plasma donors:

[0019] Choose healthy plasma donors who meet the requirements of blood product raw material plasma regulations and receive 2, 2, 1, 1, and 2 rabies vaccines on days 0, 3, 7, 14, and 28 respectively. Thirty days after the rabies vaccine is inoculated, the adsorbed tetanus vaccine shall be applied again, and the dose shall not be less than 0.5mL for 0, 14, and 28 days for immunization, and a detailed immunization record shall be established.

[0020] 2. Plasma screening and collection of plasma donors:

[0021] Select solid-phase enzyme-linked immunoassay (ELISA) to quantitatively detect the rabies antibody and tetanus antibody in the donor’s serum or plasma. The titer of rabies antibody is not less than 6IU / mL, and the titer of tetanus antibody is not less than 5IU / mL. Protein content (biuret method) not less than 55g / L, alanine aminotransferase (Ly's method) not more than 25 units, hepatitis B surface antigen negative, ...

Example Embodiment

[0054]Example 2

[0055] The double-titer human immunoglobulin for rabies and tetanus prepared in Example 1 was used to immunize patients, including 100 dog wounds, 20 rat bites, 20 cats and 20 pigs. After 4 years of continuous observation, there were no morbidity and death cases.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
Potencyaaaaaaaaaa
Antibody titeraaaaaaaaaa
Antibody titeraaaaaaaaaa
Login to view more

Abstract

The invention relates to a rabies and tetanus double valence human normal immunoglobulin, the rabies valence of antibody is not less than 100IU/mL, the tetanus valence of antibody is not less than 60IU/mL, the content of protein is not more than 175g/L, the immunoglobulin purity is not lower than 92% of the total protein content. The preparation method of source plasma of the protein is to select plasma supplier to be inoculated with rabies vaccine and then with adsorbed tetanus vaccine at least 1-5 days later to obtain the source plasma with rabies valence of antibody being not less than 6IU/mL and the tetanus valence of antibody being not less than 5IU/mL and ensure that the rabies valence of antibody of the source plasma is not less than 10IU/m and the tetanus valence of antibody is not less than 8IU/mL after mixture. The immunoglobulin of the invention can be used to immunize patients suffering exposed wounds caused by biting and scratching of a mad dog or other mad animals.

Description

technical field [0001] The invention belongs to the field of biotechnology and relates to a biological immune product, in particular to a bivalent immunoglobulin capable of simultaneously preventing human rabies and tetanus and a preparation method thereof. Background technique [0002] Rabies is an elastic virus whose pathogen is ribonucleic acid. According to the statistics of the World Health Organization, rabies is prevalent in more than two-thirds of the countries and regions in the world. my country and Southeast Asia are in the high-incidence areas of rabies in the world, and its cases account for more than 70% of the world. Once the onset of rabies, there is currently no cure, and the mortality rate is almost 100%. According to the rabies vaccination program recommended by WHO, the exposed persons are injected with human rabies immunoglobulin (RIg), and then intramuscularly injected with rabies vaccine to ensure the immune effect of the exposed persons. This method...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K39/40A61K39/42A61P31/04A61P31/14
Inventor 孙思才周凯
Owner SHANXI KANGBAO BIOLOGICAL PROD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap