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Salvia miltiorrhiza emulsion for coronary disease and preparation method thereof

The technology of Coronary Salvia miltiorrhiza and emulsion, applied in the field of medicine, can solve the problems of unfavorable product storage, poor in vitro dissolution of preparations, and reduced product curative effect, etc., and achieve the effects of improving bioavailability, increasing solubility, and enhancing drug absorption.

Active Publication Date: 2010-09-08
SICHUAN SUNNYHOPE PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] ③ The active tanshinones in Danshen medicinal materials are almost insoluble in water, and the in vitro dissolution of the preparation is poor
[0007] ④The preparations of Danshen miltiorrhiza on the domestic market are all solid preparations. The volatilization of balsamic oil in solid preparations is not conducive to product storage.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] A preparation method of coronary heart salvia miltiorrhiza emulsion, the following formula and preparation method are used to make oral emulsion:

[0022] (1) Raw materials: Danshen 600g, Panax notoginseng 600g, balm oil 5.25ml.

[0023] (2) Crush Salvia miltiorrhiza and Panax notoginseng into coarse powder, add 5-10 times of 90-95% ethanol, and obtain fat-soluble extract through alcohol extraction and refining process.

[0024] (3) The dregs are decocted with 5-10 times of 50% ethanol and 5-10 times of water to obtain a water-soluble extract through extraction and refining processes.

[0025] (4) Fat-soluble extract. Add 800-1500 g of refined soybean oil, heat to 40-60° C., stir to dissolve the solid matter completely, add balsamic oil, stir and mix evenly to obtain solution A.

[0026] (5) Appropriate amount of water, add 150~250g glycerin and heat to 40~60℃, 2 Under protection, add 100-150 g of lecithin and stir to disperse evenly. Add the water-soluble extract, ...

Embodiment 2

[0030] A preparation method of coronary heart salvia miltiorrhiza emulsion, using the following formula and preparation method to make injection emulsion:

[0031] (1) Raw materials: Danshen 600g, Panax notoginseng 600g, balm oil 5.25ml.

[0032] (2) Crush Salvia miltiorrhiza and Panax notoginseng into coarse powder, add 5-10 times of 90-95% ethanol, and obtain fat-soluble extract through alcohol extraction and refining process.

[0033] (3) The dregs are decocted with 5-10 times of 50% ethanol and 5-10 times of water to obtain a water-soluble extract through extraction and refining processes.

[0034] (4) Fat-soluble extract. Add 800-1500 g of refined soybean oil, heat to 40-60° C., stir to dissolve the solid matter completely, add balsamic oil, stir and mix evenly to obtain solution A.

[0035] (5) Appropriate amount of water for injection, add 150-250g of glycerin and heat to 40-60°C, 2 Under protection, add 100-150 g of lecithin and stir to disperse evenly. Add the wat...

Embodiment 3

[0039] A preparation method of coronary heart salvia miltiorrhiza emulsion, the following formula and preparation method are used to make oral emulsion:

[0040] (1) Raw materials: Salvia miltiorrhiza 600g, Panax notoginseng 600g, Dalbergia 6000g.

[0041] (2) Grind Danshen, Panax notoginseng and Jiangxiang into coarse powder. Add balsamic to infiltrate with water, carry out steam distillation, collect the distillate, refrigerate for 24 hours, separate the balsamic oil layer to obtain balsamic oil. The aqueous solution is subjected to a refining process to obtain a water-soluble extract.

[0042] (3) Add 5-10 times of 90-95% ethanol to the coarse powder of salvia miltiorrhiza and notoginseng, and obtain fat-soluble extract through alcohol extraction and refining process.

[0043] (4) The medicinal dregs are decocted with 5-10 times of 50% ethanol and 5-10 times of water to obtain a water-soluble extract through extraction and refining processes.

[0044] (4) Salvia miltiorr...

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PUM

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Abstract

The invention discloses a Salvia miltiorrhiza emulsion for coronary disease and a preparation method thereof. The Salvia miltiorrhiza emulsion for coronary disease is an emulsion preparation which is prepared by adding pharmaceutical excipients in Salvia miltiorrhiza extract, pseudo-ginseng extract and dalbergia wood extract and regulating the mixture to the appropriate pH value. The invention overcomes partial defects in the existing solid preparations, prepration process thereof and clinical applications, improves drug solubility and stability, and has the advantages of long-acting property, slow release, extended pharmacological effects, enhanced drug absorption, improved bioavailability and the like and solves the problems that most of the active ingredients of Salvia miltiorrhiza have very short t1 / 2, tanshinone is insoluble in water, the dissolution by oral administration is poor and the bioavailability is low; in addition, part of the active ingredients of the product have poorthermal stability, and extract liquid is not needed to be prepared into a dry extract, thereby reducing the loss of the active ingredients during the concentration and the preparation forming processand enhancing the efficacy.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a coronary heart salvia miltiorrhiza emulsion and a preparation method thereof. Background technique [0002] Coronary Danshen preparation is clinically used for the treatment of coronary heart disease and cerebrovascular disease. At present, the domestic listed products include Guanxin Danshen Granules, Guanxin Danshen Tablets, Guanxin Danshen Dropping Pills, etc. The prescriptions are: 200g of Danshen, 200g of Panax notoginseng, and 1.75ml of balsamic oil. The pharmacologically active chemical components of Salvia Miltiorrhiza include water-soluble parts and fat-soluble parts. The water-soluble parts are mainly phenolic compounds, and the fat-soluble parts are mainly diterpenoids. Others include sterols, sugars and flavonoids. Coronary miltiorrhiza preparation is used as medicine with its fat-soluble and water-soluble components. [0003] The extraction process ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/107A61K36/53A61K36/258A61K36/48A61P9/10
Inventor 郭成辉毛长兴陈开军
Owner SICHUAN SUNNYHOPE PHARM CO LTD