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Preparation method of combined porous biological ceramics bracket

A bioceramic and combined technology, applied in medical science, prosthesis, etc., can solve the problems of weak bearing capacity of porous ceramic stents, customized production of difficult individual differences in patients, etc., and achieve the effect of improving bearing capacity

Active Publication Date: 2009-09-09
西安点云生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In order to overcome the disadvantages of weak load-carrying capacity of porous ceramic stents in the prior art and difficulty in customized production according to individual differences of patients, the present invention provides a method for preparing a combined porous ceramic stent, the method is by manufacturing bioceramic spherical particles; ;Assembly and other steps, a gradient pore porous bioceramic scaffold with relatively dense exterior and loose and porous interior is prepared, which has strong bearing capacity and can realize moldless manufacturing

Method used

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  • Preparation method of combined porous biological ceramics bracket
  • Preparation method of combined porous biological ceramics bracket
  • Preparation method of combined porous biological ceramics bracket

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Example 1: Preparation of a combined porous bioceramic scaffold with an internal pore diameter greater than 100 μm.

[0037]This porous bioceramic scaffold can ensure that osteoclasts with a diameter of 100 μm pass through each pore. Referring to Table 1, select the 24-mesh and 26-mesh sieves to screen out the internal pore structure of the spherical particle structure scaffold with a diameter between 710 and 800 μm, and the pore size is between 110 and 586 μm. The specific process is as follows:

[0038] (1.1) Take a gelatin aqueous solution with a mass concentration of 5% as a binder, mix the gelatin aqueous solution with a weight percentage of 30 wt% and the tricalcium phosphate bioceramic powder with a weight percentage of 70 wt%, and use Shenzhen Xinyite Pharmaceutical Equipment The Mini-250 Extrusion Spheronizer produced by the Co., Ltd. performs orifice plate extrusion, cutting and spheronization processes on ceramic powder to produce tricalcium phosphate spheri...

Embodiment 2

[0044] Example 2: Preparation of a combined porous bioceramic scaffold with an internal pore diameter of less than 400 μm.

[0045] This porous bioceramic scaffold has good osseointegration performance. Studies have shown that when the pore size is greater than 400 μm, the bonding force of bone decreases. Referring to Table 1, select 35-mesh and 40-mesh sieves to screen out the internal pore structure of the spherical particle structure scaffold with a diameter between 450 and 500 μm, and the pore size is between 70 and 366 μm. The specific process is as follows:

[0046] (2.1) Take a gelatin aqueous solution with a mass concentration of 3% as a binder, mix the gelatin aqueous solution with a weight percentage of 20 wt% and the calcium-deficient hydroxyapatite bioceramic powder with a weight percentage of 80 wt%, and use Shenzhen Sine The Mini-250 extrusion spheronizer produced by Te Pharmaceutical Equipment Co., Ltd. implements orifice plate extrusion, cutting and spheroniz...

Embodiment 3

[0052] Example 3: Preparation of a combined porous bioceramic scaffold with an internal pore diameter of less than 800 μm.

[0053] This porous bioceramic scaffold has better blood circulation ability, which is beneficial to realize bone repair in parts far away from the heart where blood circulation is weak. Referring to Table 1, select 18-mesh and 20-mesh sieves to screen out the inside of the particle structure scaffold with a diameter between 900 and 1000 μm, and a pore size between 139 and 732 μm. The specific process is as follows:

[0054] (3.1) Take a gelatin aqueous solution with a mass concentration of 4% as a binder, mix the gelatin aqueous solution with a weight percentage of 50 wt% and the alumina bioceramic powder with a weight percentage of 50 wt%, and use Shenzhen Xinyite Pharmaceutical Equipment Co., Ltd. The Mini-250 extrusion spheronizer produced by the company performs orifice plate extrusion, cutting and spheronization processes on the ceramic powder to p...

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Abstract

The invention discloses a preparation method of a combined porous biological ceramics bracket. The grads porous biological ceramics bracket with a relatively compact outer part and a porous smooth inner part is prepared by the steps of manufacturing biological ceramics spherical particles and a three dimensional shell, assembling and the like. The mean counter bending strength of the material of the shell reaches 25.4-30.7MPa. The porous biological ceramics bracket prepared by the preparation method has the characteristics of forming without depending on a mould, customizing according the difference of a patient, and rapidly producing the biological ceramics bracket.

Description

technical field [0001] The invention relates to a preparation method of a porous bioceramic support, in particular to a preparation method of a combined porous bioceramic support. Background technique [0002] For bone tissue with lesion or damage, natural bone such as body bone, allogeneic bone, heterogeneous bone or artificial bone can be used for repair. Artificial bone can be designed, produced on demand and easy to standardize, so as to solve various problems of bone repair in a long-lasting and effective way. In order to ensure the transport of bone cells and nutrients in the scaffold and promote the growth of new bone, artificial bone often needs to be made into a porous structure. However, the porous structure will reduce the mechanical properties of the material. The actual human bone has the characteristics of being dense and strong on the outside (called compact bone) and loose and porous on the inside (called cancellous bone). [0003] The document "Chinese In...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/10A61L27/56
Inventor 曾庆丰张立同闫秀天成来飞刘永胜汪焰恩宋佳音栾新刚
Owner 西安点云生物科技有限公司
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