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Pharmaceutical composition for resisting osteoporosis

An anti-osteoporosis and osteoporosis technology, applied in the field of medicine

Inactive Publication Date: 2009-09-30
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
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Problems solved by technology

Although these compounds reduce bone loss through different pathways, there has been no report of using the above active substances to form a pharmaceutical composition for the prevention and treatment of osteoporosis

Method used

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  • Pharmaceutical composition for resisting osteoporosis
  • Pharmaceutical composition for resisting osteoporosis
  • Pharmaceutical composition for resisting osteoporosis

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Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0080] The present invention is described in detail in conjunction with embodiment now.

[0081] 1. Effect experiment of icariin and timosaponin BII composition on osteoblasts

[0082] 1 Materials and methods

[0083] Reagents and materials: Icariin and berberine are products of Shaanxi Huike Plant Development Co., Ltd., with a purity of 99%. Timosaponin BII and Curculigoside B are self-made by our research group, and tested by H-NMR, Spectrum analysis such as mass spectrometry is consistent with literature data, and HPLC analysis shows that the purity reaches more than 99%. Genistein and Coomassie Brilliant Blue G-250 are products of Sigma, USA. MTT, dimethyl sulfoxide, disodium p-nitrophenol phosphate, diethanolamine, NaOH, and p-nitrophenol are domestic analytical reagents.

[0084] Newborn 2-4 day old SD rats were provided by the Experimental Animal Center of Second Military Medical University.

[0085] Solution preparation: prepare 10 -4 mol / L icariin and timosaponin ...

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Abstract

The invention relates to the technical field of medicaments, in particular to a pharmaceutical composition for resisting osteoporosis, which consists of any two, three or four components of icariin, timosaponin-B II, curculigoside B and berberine respectively and is characterized in that the composition consists of the following components by weight portion: 0 to 135 portions of the icariin, 0 to 450 portions of the timosaponin-B II, 0 to 63 portions of the curculigoside B, and 0 to 1,350 portions of the berberine. The composition can promote the formation of osteoblasts synergistically and inhibit the bone resorption of osteoclasts, and can reinforce the function of resisting the osteoporosis through synergistic adjustment of a plurality of correlative indexes of bone metabolism to achieve the aim of preventing and treating the osteoporosis, thus the composition can be applied to preparing medicaments for preventing the osteoporosis.

Description

technical field [0001] The invention relates to the technical field of medicine, and is a pharmaceutical composition for anti-osteoporosis. The composition is composed of any two, three or four components of icariin, timosaponin BII, curculin B and berberine, through the synergistic regulation of multiple related indicators of bone metabolism, Reduce bone loss, increase bone density, and enhance the anti-osteoporosis effect. Background technique [0002] Osteoporosis is a systemic and systemic skeletal disease characterized by decreased bone mass and microstructural destruction of bone tissue, resulting in increased bone fragility and increased risk of fracture. It mostly occurs in postmenopausal women and is a senile disease. category. Occurrence of osteoporosis is related to metabolic disorders of the endocrine system in old age, excessive production of superoxide in the body, and immune dysfunction, etc., and thus cause bone metabolism disorders, such as decreased forma...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61K31/7034A61K31/4375A61P19/10
Inventor 张巧艳焦磊燕菲秦路平韩婷
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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