Dental implant and preparation method of bioactive antibacterial surface of dental implant

A dental implant and bioactive technology, applied in the field of preparation of dental implants and their bioactive antibacterial surfaces, can solve the problems of being susceptible to bacterial infection and low bioactivity, and achieve good long-term antibacterial performance, convenient preparation, and improved stability. Effects of Sex and Success Rates

Inactive Publication Date: 2017-08-29
UNIV OF SCI & TECH BEIJING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to solve the problems of existing dental implant materials that are susceptible to bacterial infection and low biological activity, improve the antibacterial performance of the material surface, and accelerate the osseointegration with surrounding tissues, the purpose of the present invention is to provide a bioactive antibacterial surface grown in situ. The dental implant and its preparation method are suitable for any shape of the implant surface, and the strong bonding force between the film layer and the matrix makes the surface modification have long-term stability, endows the implant surface with antibacterial properties, and promotes early cell growth Adhesion, spreading, proliferation and differentiation are conducive to the osseointegration of implants, thereby improving the stability and success rate of implants

Method used

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  • Dental implant and preparation method of bioactive antibacterial surface of dental implant
  • Dental implant and preparation method of bioactive antibacterial surface of dental implant
  • Dental implant and preparation method of bioactive antibacterial surface of dental implant

Examples

Experimental program
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Effect test

Embodiment 1

[0034] A dental implant, the surface of which is treated by:

[0035] (1) Select medical pure titanium dental implants as the substrate, and perform surface cleaning: ultrasonic cleaning with acetone, absolute ethanol, and deionized water for 15 minutes, and then dry naturally;

[0036] (2) Configure the anodic oxidation electrolyte: the electrolyte used is an aqueous glycerol solution of ammonium fluoride, in which the mass fraction of ammonium fluoride is 0.5 wt%, and the volume fraction of water is 2 vol%;

[0037] (3) Preparation of uniform titanium dioxide nanotube film layer by anodic oxidation method: using constant voltage direct current anodic oxidation technology, the pure titanium dental implant after step (1) is used as the anode, and the graphite electrode or platinum sheet electrode is used as the cathode, and put into the step ( 2) In the prepared electrolyte; the working voltage is 20 V, the oxidation time is 3 h, and the reaction temperature is room temperatur...

Embodiment 2

[0050] A dental implant, the surface of which is treated by:

[0051] (1) Select medical pure titanium dental implants as the substrate, and perform surface cleaning: ultrasonic cleaning with acetone, absolute ethanol, and deionized water for 15 minutes, and then dry naturally;

[0052] (2) Configure the anodic oxidation electrolyte: the electrolyte used is an aqueous glycerol solution of ammonium fluoride, in which the mass fraction of ammonium fluoride is 0.5 wt%, and the volume fraction of water is 25 vol%;

[0053] (3) Preparation of uniform titanium dioxide nanotube film layer by anodic oxidation method: using constant voltage direct current anodic oxidation technology, the pure titanium dental implant after step (1) is used as the anode, and the graphite electrode or platinum sheet electrode is used as the cathode, and put into the step ( 2) In the prepared electrolyte; the working voltage is 30 V, the oxidation time is 2 h, and the reaction temperature is room temperatu...

Embodiment 3

[0060] A dental implant, the surface of which is treated by:

[0061] (1) Select medical pure titanium dental implants as the substrate, and perform surface cleaning: ultrasonic cleaning with acetone, absolute ethanol, and deionized water for 15 minutes, and then dry naturally;

[0062] (2) Configure the anodic oxidation electrolyte: the electrolyte used is an aqueous glycerol solution of ammonium fluoride, in which the mass fraction of ammonium fluoride is 1 wt%, and the volume fraction of water is 50 vol%;

[0063] (3) Preparation of uniform titanium dioxide nanotube film layer by anodic oxidation method: using constant voltage direct current anodic oxidation technology, the pure titanium dental implant after step (1) is used as the anode, and the graphite electrode or platinum sheet electrode is used as the cathode, and put into the step ( 2) In the prepared electrolyte; the working voltage is 40 V, the oxidation time is 2 h, and the reaction temperature is room temperature...

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Abstract

The invention relates to a dental implant and a preparation method of a bioactive antibacterial surface of the dental implant. The dental implant is characterized in that medical titanium or a titanium alloy is taken a substrate; a nanotube morphology is constructed on the surface of the substrate through anodic oxidation; the surface of the substrate is uniformly coated with a polydopamine bionic membrane layer formed by auto-polymerization; the dental implant with the bioactive antibacterial surface provided with in-situ grafted silver nanoparticles is obtained by means of the adsorption and reduction capabilities of a polydopamine surface for silver ions. By adopting the dental implant, a uniform discrete nanotube oxide layer is formed in situ on the surface of the titanium substrate to be taken as a storage carrier of a large quantity of antibacterial silver particles, and the bioactive antibacterial surface which grows in situ is prepared through the steps of surface dopamine auto-polymerization and in-situ soaking and reduction and the like, so that the implant surface has more durable antibacterial property, the hydrophilic performance and bioactivity of the surface are improved, the alkaline phosphatase activity of osteoblast on the implant surface is increased, the differentiation of the osteoblast is facilitated, the infection risk of the implant after the implant is implanted is lowered, and the implanting success rate is increased.

Description

technical field [0001] The invention relates to the field of dental implant materials, in particular to a preparation method of a dental implant and its bioactive antibacterial surface. Background technique [0002] During the clinical use of medical titanium and its alloys, due to their good biocompatibility, a protein layer is easily formed on the surface after implantation into the human body, so that bacteria accumulate on the surface to form a biofilm. Under the protection of biofilm, bacteria can not be attacked by the host defense system, which facilitates the concentration of bacteria and the occurrence of infection. In addition, the biologically inert surface of titanium is difficult to chemically bond with bone tissue, and it is easy to form a fibrous tissue compartment at the interface between the implant and living tissue, causing the implant to loosen, which is also the main reason for the failure of titanium dental implant materials. one of the reasons. In th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/30A61L27/06A61L27/34A61L27/54C25D11/26C23C18/42C23C28/00
CPCA61L27/306A61L27/06A61L27/34A61L27/54A61L2300/104A61L2300/404A61L2300/412A61L2300/606A61L2400/12A61L2420/06A61L2430/12C08L79/04C23C18/42C23C28/322C23C28/3455C25D11/26
Inventor 董超芳章彦娴吴俊升肖葵黄运华李晓刚杨瑟飞倪晓晴
Owner UNIV OF SCI & TECH BEIJING
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