Perforated brick type filling support type reactor used in artificial liver

A reactor and perforated brick technology, applied in suction equipment, blood circulation treatment, etc., can solve the problems of easy generation of ineffective space, dead space, uneven distribution, etc., to reduce liquid flow resistance, strong comprehensive performance, and simple production process. Effect

Active Publication Date: 2009-10-07
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the most clinical application is the hollow fiber reactor, which has the functions of immune isolation and oxygenation, and the cells are less sheared, but has the following disadvantages: 1. The traditional hollow fiber reactor has insufficient space for cell growth and uneven distribution. 2. It can only provide two-dimensional culture, but not three-dimensional culture; 3. The semi-permeable membrane barrier or collagen layer will affect the material exchange efficiency; 4. Cells grow on the surface of the fiber, so it is easy to block the fiber hole
But it has the following disadvantages: 1. There is a potential safety hazard of lack of immune isolation; 2. The oxygen supply of cells is insufficient; 3. The center and edge of the entire reactor support are prone to produce dead space and dead space; 4. Through a large number of supports The resistance is large, and the required perfusion intensity is high, which causes the cells to be subjected to a large shear force and is difficult to amplify
The existing reactors with good comprehensive performance in the world often have complex structures, high manufacturing process requirements, and high costs.

Method used

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  • Perforated brick type filling support type reactor used in artificial liver
  • Perforated brick type filling support type reactor used in artificial liver
  • Perforated brick type filling support type reactor used in artificial liver

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Embodiment Construction

[0025] The artificial liver porous brick type filled bracket type reactor of the present embodiment comprises a cuboid transparent plexiglass reactor shell 7, and the reactor shell 7 is divided into three compartments by two dense grid-covered partition plates 5, from the bottom to the bottom. The above are the oxygenation cabin, the filling bracket cabin, and the immune barrier cabin. The oxygenation cabin and the filling bracket cabin are integrated, and the immune barrier cabin is an independent component, which is connected with the aforementioned whole through a sealed bayonet cover 6 .

[0026] Air-permeable and impermeable hollow fibers 3 are arranged horizontally in the oxygenation chamber, and a liquid inlet 8 is arranged at the bottom of the chamber. The inside of the hollow fiber 3 is a gas channel, and the two ends are respectively connected with a gas inlet 10 and a gas outlet 11 . The hollow fiber 3 of the oxygenation chamber is a breathable and impermeable poly...

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PUM

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Abstract

The invention relates to a perforated brick type filling support type reactor used in artificial liver, belongs to the medical equipment field. The reactor comprises a reactor housing; the inside of the reactor is divided into three cabins by two isolation plates densely covered by grids: an oxygenation cabin, a filling support cabin and a immunization obstructing cabin disposed from up down. The invention adopts unique perforated brick type fixing bed as the inner main body of the reactor; divides the inside of the reactor into minisized independent units by unconnected elongated hole columns in the fixing bed; divides up the inner cavity of the reactor, reduces unavailability cavity, dead cavity and liquid flow resistance to cause the inner liquid flow of the reactor to be uniform; not only solves the problems of immunization isolation lack and insufficient oxygen supply, but also compensates the defects of cell growth space deficiency, poor cell adhesion, no three dimensional growth environment and easily semipermeable membrane obstruction in hollow fiber type reactor; combines the functions of oxygenation, immunization obstruction and three dimensional cultivation; achieves strong properties, simple manufacturing technology and low cost, and is easily to be amplified.

Description

technical field [0001] The invention relates to a medical device, which is a core device for biological or hybrid artificial liver treatment-a porous brick-type filled-stent type reactor for artificial liver. Background technique [0002] As one of the effective treatment methods for patients with severe hepatitis and liver failure, artificial liver support therapy has been recognized all over the world. It includes three categories of non-biological, biological and hybrid artificial livers, of which the latter two are the main international development directions. Bioreactor (i.e., reactor) is the core device of biological and hybrid artificial liver treatment, which not only provides a place for material exchange between exogenous liver cells and patient blood or plasma, but also provides a suitable growth environment for liver cells. The application prospect is broad. An ideal artificial liver bioreactor should meet the following basic requirements: 1. Sufficient space ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M1/00A61M1/38
Inventor 李兰娟朱春侠喻成波杜维波吕国良郝绍瑞
Owner ZHEJIANG UNIV
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