Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

New purpose of triterpene substance

A technology of triterpenoids and substances, applied in the field of medicine, can solve the problems of elevated white blood cells, no literature reports, etc.

Active Publication Date: 2009-10-14
XIANGBEI WELMAN PHARMA CO LTD
View PDF0 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, there are currently few reports on the pharmacological effects of triterpenoids extracted from Eclipta chinensis. So far, no literature has reported the effects of this type of compounds on regulating immunity and increasing white blood cells.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • New purpose of triterpene substance
  • New purpose of triterpene substance
  • New purpose of triterpene substance

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0113] Compound Eclipta prostrate Linn. Extracted from Eclipta prostrate Linn.

[0114] (1) soaking and extraction

[0115] Dry the whole herb of Channa saustrii, select 10 kg of leaves, add 8 times the volume of 95% ethanol, soak for 4 hours, heat and reflux for extraction for 1 hour, suction filter while it is hot, add 8 times the volume of 95% ethanol to the residue and heat and reflux for 1 hour, Suction filtration while hot; combine the two filtrates, place in refrigerator overnight, and suction filtration to obtain a clear filtrate.

[0116] (2) Sample preparation

[0117] Concentrate under reduced pressure to recover ethanol until the concentrated thick paste turns dark green, pour it out. Take 1.0 kg of thick paste, add 7 times the volume of distilled water at 100°C, stir and mix well, and then filter with suction; add 4 times the volume of distilled water at 100°C, stir and mix well, and then filter with suction; combine the two water solutions, Instantly.

[0118...

Embodiment 2

[0142] Extraction of triterpenoids from snakehead intestine (Eclipta prostrate Linn.)

[0143] (1) soaking and extraction

[0144] Dry whole herb of Eclipta chinensis, select 10 kg of leaves, add 80 liters of 95% ethanol, soak for 4 hours, heat and reflux for extraction for 1 hour, filter while hot, add 80 liters of 95% ethanol for heating and reflux to extract for 1 hour, Suction filtration while hot, and discard the medicinal residue; combine the two filtrates, place at 4°C for 12 hours, and suction filtration to obtain a green and clear filtrate.

[0145] (2) Ethanol recovery

[0146] Under the pressure of negative 0.1 MPa, the temperature does not exceed 60 degrees Celsius, and the ethanol is recovered under reduced pressure, until the relative density of the concentrated thick paste is about 1.3 g / ml at 60 degrees Celsius, pour it out to obtain a dark dark green thick paste.

[0147] (3) Dissolved in hot water

[0148] Take 1.0 kg of thick paste, add 5 liters of distil...

Embodiment 3

[0156] Therapeutic effect of triterpenoids on cyclophosphamide-induced leukopenia in mice

[0157] Experimental animals:

[0158] Sixty male SPF-grade C57BL / 6 mice were purchased from Shanghai Slack Experimental Animal Co., Ltd., weighing 22-24 g. Animals were housed in an SPF-grade animal room with 12 hours of light / 12 hours of darkness and free access to feed and water.

[0159] Experimental Drugs:

[0160] The sample prepared by Example 1, numbering APL-2;

[0161] The sample prepared by Example 2, numbering APL-3;

[0162] Likejun, purchased from Jiangsu Jibeier Pharmaceutical Co., Ltd.;

[0163] Cyclophosphamide for injection was purchased from Changzhou Xinli Pharmaceutical Chemical Co., Ltd.

[0164] experimental method:

[0165] 1. Modeling method:

[0166] In addition to the normal control group, the rest of the animals were randomly divided into 5 groups, intraperitoneal injection of cyclophosphamide 100mg / kg body weight for 3 consecutive days to create a leuk...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a purpose of a triterpene substance. The triterpene substance is one compound or more compounds or pharmaceutically acceptable salts or esters as the formula I, wherein R1 is selected from glucosyl group, glucose (1-2) glucose, glucose (1-4) glucose, or (2'-OSO3H) glucose; R2 is hydroxyl group, alcohol group or hydrogen atom; R3 is alkyl, carboxyl, alcohol group or COOGlu;R4 is alkyl or carboxyl; R5 is alkyl; and R6 is carboxyl or hydrogen atom. The triterpene substance can be used for preparing a compound preventing and curing leukocytopenia.

Description

technical field [0001] The invention belongs to the field of pharmacy, and more specifically relates to a new application of triterpenes. Background technique [0002] Eclipta prostrate Linn. is a traditional Chinese medicinal material. It is the whole herb of Eclipta prostrate Linn., which was first recorded in "Tang Materia Medica". Traditional Chinese medicine believes that Eclipta is sweet and sour in nature, cool, enters the liver and kidney meridians, has the effect of nourishing the liver and blood, cooling blood and stopping bleeding, and is mainly used for vomiting blood, coughing up blood, premature graying of beard and hair, turbid stranguria, and leukorrhea. According to reports, the whole herb of Eclipta contains saponins, flavonoids, saponins, tannins, vitamins, nicotine, and various thiophene compounds; the leaves contain coumarin compounds, such as wedelide, demethylwedelide and Demethylwedelolide-7-glucoside. Zhang Mei et al. isolated 4 triterpenoids from ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/704A61P7/00A61P43/00
Inventor 俞强
Owner XIANGBEI WELMAN PHARMA CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com