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Compound material for internal fixation of tendons carrying transgenic cells and preparation method thereof

A technology of transgenic cells and composite materials, which is applied in the field of materials for surgical supplies to achieve the effects of easy operation, convenient operation and prevention of adhesion

Inactive Publication Date: 2012-09-12
张朝跃
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there is no data showing that there is a repair method or material that can not only stabilize the internal environment of the tendon, promote the healing of the injured tendon, but also enable early functional exercise and effectively prevent tendon adhesion

Method used

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  • Compound material for internal fixation of tendons carrying transgenic cells and preparation method thereof
  • Compound material for internal fixation of tendons carrying transgenic cells and preparation method thereof

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Experimental program
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Effect test

Embodiment

[0029] Such as figure 1 As shown, a strip-shaped composite material for internal fixation of tendon carrying transgenic cells, the composite material is composed of an outer layer of non-degradable tendon surface internal fixation polyester material layer 1 and an inner layer of pharmacologically acceptable The biodegradable matrix film material layer 2 rich in micropores is compounded. The non-degradable polyester material layer 1 internally fixed on the surface of the tendon is composed of inner and outer layers, and the outer layer is made of polyethylene terephthalate, which is rich in microporous polyethylene terephthalate. Ethylene formate film 11 (nano-scale pores are evenly distributed on the film, and the hole density is 4500 / mm 2 , the pore diameter is about 0.6nm, and the thickness is 20μm), and its inner layer is a polyethylene terephthalate network structure 12 (thickness is 1.1mm) made of polyethylene terephthalate. The matrix material of biodegradable matrix f...

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Abstract

The invention discloses a compound material for the internal fixation of tendons carrying transgenic cells. The compound material is formed by compounding a non-degradable tendon surface internal fixation polyester material layer as the outer layer and a pharmacologically acceptable biodegradable porous substrate film material layer as the inner layer, wherein, the inner layer adopts the biodegradable substrate film as the base material obtained through the surface modification treatment of substances capable of improving the hydrophilicity and cell affinity thereof and the inoculation of tendon cells subjected to the transfection of genes carrying the related cell factors for promoting the healing of tendons. The preparation method of the compound material comprises the following steps: firstly, preparing the non-degradable tendon surface internal fixation polyester material compound and the surface-modified biodegradable substrate film; then, preparing the transgenic tendon cells, and inoculating the transgenic tendon cells onto the biodegradable substrate film; and finally compounding to obtain the compound material of the invention. The compound material prepared by the invention has the advantages of good biocompatibility and higher tensile strength and is capable of stabilizing the internal environment of the tendons and promoting the healing of the tendon injury.

Description

technical field [0001] The invention relates to a material for surgical supplies, in particular to a composite material for repairing tendon damage. Background technique [0002] In the field of orthopedics, tendon injury is a common clinical disease, such as traumatic tendon injury, spontaneous tendon injury, tumor or tuberculosis and other lesions. If the tendon injury is not repaired in time, it will cause limb dysfunction. Therefore, timely surgical repair and functional reconstruction after tendon injury have become the focus of orthopedic surgery. [0003] The ideal repair principle of tendon injury is to restore the continuity and biomechanical strength of tendon collagen fibers as much as possible, and at the same time restore its smooth surface without adhesion with surrounding tissues. The development of modern surgical techniques has made great progress in the repair of tendon injuries. However, in the actual healing process of tendon injuries, the repaired struc...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/40A61L27/38A61L27/54A61L27/56A61L27/58A61L27/18
Inventor 张朝跃
Owner 张朝跃
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