Method for synthesizing three direction dendrimer core by microwave

Abstract

The invention relates to a method for synthesizing three direction dendrimer core by microwave, comprising the following steps: synthesizing dinitrile: dissolving trolamine in a reaction vessel with 1,4-dioxane, adding a strong base catalyst and a crown ether phase transfer catalyst; then adding acrylonitrile in the reaction system, placing the solution in a microwave reactor for microwave irradiation to obtain dinitrile; synthesizing triester: dissolving the obtained dinitrile in a reaction vessel with methanol, adding concentrated sulphuric acid; placing the solution in the microwave reactor for microwave irradiation to obtain triester; synthesizing triamine: dissolving the obtained triester in a reaction vessel with methanol, adding ethylene diamine; placing the solution in the microwave reactor for microwave irradiation to obtain three direction dendrimer core. Compared with the existing art, the invention has the following advantages: the radiation energy is large by microwave heating, the synthetic reaction time of dendrimer core is effectively shortened; the productivity can be obviously improved, which is obvious for the alcoholysis of nitrile.

Description

technical field [0001] The invention relates to a method for synthesizing a three-directional dendritic molecular nucleus by microwave. Background technique [0002] Dendrimers are a new class of synthetic macromolecules, and their many unique properties have attracted widespread attention in related fields in recent years. It has the characteristics of high geometric symmetry, precise molecular structure, low dispersion coefficient, a large number of surface functional groups, and controllable internal cavity and molecular size. It can be used in many fields such as catalysis, drug metabolism, and gene carrier. . [0003] The research results show that, among many dendrimers, polyamide-amine dendrimers are open and relatively loose structures at low generation (below 3 generations), and are closely packed on the surface at high generation (more than 4 generations). structure. The molecular size of polyamide-amine dendrimer is in the nanometer range, and the molecular siz...

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Problems solved by technology

However, these reactions are all time-consuming when conventional methods are used for synthesis at present, and there is also the problem of low yield in the step of nitrile alcoholysis, so that the synthesis cycle of the whole dendrimer is delayed and the corresponding Synthetic cost, thus limiting the application and development of the same class of dendrimers themselves

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