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Herbal composition for skin care

A skin and herbal technology, applied in skin diseases, skin care preparations, pharmaceutical formulations, etc., can solve problems such as collagen cannot be replaced, light deterioration, reduction, etc.

Active Publication Date: 2009-11-25
SAGITTARIUS LIFE SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The production of type 1 and type 3 collagen decreases during the aging process, and the light makes it worse, so that the damaged collagen cannot be replaced

Method used

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  • Herbal composition for skin care
  • Herbal composition for skin care
  • Herbal composition for skin care

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0157] Embodiment one, combination and preparation method

[0158] CPF+ combination

[0159] CPF+ includes ginseng, acanthopanax bark and safflower, and its composition weight percentage is 0.1-1:0.1-1:0.03-0.3.

[0160] CPF+ preparation method

[0161] 1. The safflower is refluxed with 5 to 10 times of water at 100±5°C for one hour, and the supernatant is sieved with 400 mesh, and the supernatant is concentrated and dried, which is called CPFa.

[0162] 2. Reflux ginseng and Wujiapi with 5 to 10 times of 50±10% alcohol at 100±5°C for one hour, twice. The secondary supernatant was screened with 400 mesh, and this supernatant was concentrated and dried and called CPFb.

[0163] The supernatant of 1. and the supernatant of 2. are mixed, concentrated, and dried, which is called CPF+.

[0164] CM23 combination

[0165] CM23 contains agarwood and frankincense in a weight percentage ratio of 0.3-3:0.3-3.

[0166] CM23 preparation method

[0167] Agarwood and frankince...

Embodiment 2

[0168] Embodiment two, stimulating dermal fibroblasts to divide

[0169] Human dermal fibroblasts were cultured in DMEM + 10% FCS (fetal calf serum) + 100Units / ml Penicillin (penicillin) + 100μg / ml Streptomycin (streptomycin) + 2mM Glutamine (glutamine) + 0.1mM Sodium pyruvate (pyruvate) Sodium) culture solution (Complete-medium (complete culture solution), C-medium) was cultured at 37° C. with 5% carbon dioxide.

[0170] 1×10 4 The cells were planted in a 96-well culture dish, and after 24 hours, fresh C-medium containing herbal combination was added to continue the culture. After 4 days, it was replaced by MTT (cell viability test) containing 0.5mg / ml PBS (phosphate buffered saline), cultivated for 4 hours under the same conditions, then the MTT culture solution was sucked off, and Isopropanol (isopropanol) containing 0.04N hydrochloric acid was added. propanol) to dissolve the formed Formazan (formazan), and then read the absorbance at a wavelength of 570 nm.

[0171] Ta...

Embodiment 3

[0174] Embodiment three, stimulating dermal fibroblasts to synthesize collagen and glucosamine

[0175] 5×10 4 The cells are planted in 48-well culture dishes, and the cells are allowed to grow in 3 to 4 days. C-medium contains or does not contain hydrogen peroxide, plus 25μg / ml vitamin C and herbal combination, or genistein or vitamin a. Seven days later, the cells were fixed with 10% formalin, and then stained with Sirius Red, Safranin O or Alcian Blue (pH2.5).

[0176] A. In C-medium without hydrogen peroxide, compared with fibrinoxanthin, it stimulates the synthesis of collagen and glucosamine in dermal fiber collagen mother cells.

[0177] Table 2 Stimulation of collagen and glucosamine synthesis by dermal fiber collagen mother cells

[0178] CPFa

CPFb

CPF+

CM23a

CM23b

CM23

Finch yellow

white

control

Group

Sirius

red

++

++

+++

++

+++

...

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Abstract

The present invention provides an herbal composition for improving aging skin, comprising extract of Panax ginseng, Acanthopanax and Carthamus tinctorius. The composition of present invention can further comprise extract of Lignum aquilariae and Resina boswelliae carterii.

Description

technical field [0001] The present invention relates to a herbal compound for aging skin maintenance. Background technique [0002] The skin is a very complex organ consisting of two tissues: the epidermis and the dermis. The epidermis is a multilayered differentiated tissue that functions as a barrier. The dermis is connective tissue whose cells are embedded in a matrix composed of collagen, elastin, glycoproteins, and other macromolecules. Collagen makes up 70-80% of the dry weight of the skin and it gives the skin its tension. Elastin is a small amount of protein in the dermis that imparts elasticity to the skin (Emmanuelle Noblesse; et al. J. Invest. Dermatol. 2004; 122:621-630). Glycoproteins are highly charged and attract water molecules, plumping and plumping the skin. [0003] Clinically relevant histological manifestations of skin aging include thinning of the epidermis due to decreased mitosis and differentiation of basal cells, flattening of the reticulum cris...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/286A61K36/835A61K8/97A61P17/18A61Q19/08
CPCA61K36/254A61P17/18
Inventor 刘素莹
Owner SAGITTARIUS LIFE SCI
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