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Material for repairing defect of human body bone and preparation method thereof

A bone defect and human body technology, applied in the direction of prosthesis, medical science, coating, etc., can solve the problems of degradability and insufficient strength, and achieve the effect of eliminating or reducing stress shielding and good permeability

Inactive Publication Date: 2009-11-25
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Found through literature search to prior art, Gogolewski S. " Bioresorbable polymers in trauma and bone surgery " published on " Injury " 2000 No. 31 period 28-32 pages (biodegradable polymer in trauma and orthopedics) In this paper, the defect repair is completed by controlling the degradation rate of the polymer material so that it is carried out simultaneously with the replacement of new bone, but it has not yet resolved the contradiction between degradability and insufficient strength.

Method used

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  • Material for repairing defect of human body bone and preparation method thereof
  • Material for repairing defect of human body bone and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Example 1 Preparation of materials for repairing human bone defects with a diameter of 1mm, the specific steps are as follows:

[0026] The first step is to randomly wind and shape pure titanium fibers with a diameter of 50 μm to prepare fibrous porous titanium microspheres with irregular three-dimensional interconnected pores. The diameter of the microspheres is 1 mm, the porosity is 78.0%, and the pore size distribution is 100-500 μm , the pores are interconnected, such as figure 1 As shown, the fibrous porous titanium microspheres were ultrasonically cleaned with distilled water for 10 minutes, and then sterilized under high temperature and high pressure for later use;

[0027] The compressive strength of the fibrous porous titanium microspheres is 16.0MPa, and the modulus of elasticity is 1.20GPa;

[0028] In the second step, 5 g of nano-strontium apatite with a purity of 99.99% was ultrasonically cleaned with distilled water for 10 minutes, sterilized by high temp...

Embodiment 2

[0030] Embodiment 2 prepares the material of the human body bone defect repair of diameter 2mm, concrete steps are as follows:

[0031] The first step is to randomly wind and shape pure titanium fibers with a diameter of 80 μm to prepare fibrous porous titanium microspheres with irregular three-dimensional interconnected pores. The diameter of the microspheres is 2 mm, the porosity is 80.0%, and the pore size distribution is 100-600 μm , the pores are interconnected, such as figure 1 As shown, it was ultrasonically cleaned with distilled water for 10 minutes, and then sterilized under high temperature and high pressure for later use;

[0032] The compressive strength of the described fibrous porous titanium microspheres is 15.6MPa, and the modulus of elasticity is 1.05GPa;

[0033] In the second step, 5 g of nano-strontium apatite with a purity of 99.99% was ultrasonically cleaned with distilled water for 10 minutes, and then sterilized by high temperature and high pressure, ...

Embodiment 3

[0035] Example 3 Preparation of materials for repairing human bone defects with a diameter of 1.5mm, the specific steps are as follows:

[0036] The first step is to randomly wind and shape pure titanium fibers with a diameter of 100 μm to prepare fibrous porous titanium microspheres with irregular three-dimensional interconnected pores. The microspheres have a diameter of 1.5 mm, a porosity of 82.0%, and a pore size distribution of 100- 800μm, the pores are interconnected, such as figure 1 As shown, it was ultrasonically cleaned with distilled water for 10 minutes, and then sterilized by high temperature and high pressure for later use.

[0037] The compressive strength of the fibrous porous titanium microspheres is 15.0MPa, and the modulus of elasticity is 0.90GPa;

[0038] In the second step, 5 g of nano-strontium apatite with a purity of 99.99% was ultrasonically cleaned with distilled water for 10 minutes, and then sterilized by high temperature and high pressure, and th...

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Abstract

The invention provides a material for repairing defect of human body bone and a preparation method thereof, the material includes: a fibre porous titanium microsphere, a nano fermorite layer, wherein,nano fermorite layer packs the fibre porous titanium microsphere, and the average diameter of the fibre porous titanium microsphere is 1-2 mm, the pore size distribution is 100-800 mu m, and the porosity is 80.0% plus or minus 2.0%. The porosity of the material for repairing defect of human body bone prepared according to the invention is 80.0% plus or minus 2.0%, and the pore space is mutually communicated, the pressive strength is 15.0-16.0 MPa, and the elastic modulus is 0.90-1.20 GPa.

Description

technical field [0001] The invention relates to a material in the technical field of biomedical engineering and a preparation method thereof, in particular to a material for repairing human bone defects and a preparation method thereof. Background technique [0002] Bone defects caused by trauma, congenital deformities or congenital diseases, tumor resection, infection, and osteoporotic fractures are one of the important causes of human disability, and are also important factors in orthopedic surgery, craniomaxillofacial surgery, and plastic surgery. A common problem faced by many disciplines. The purpose of repairing and reconstructing bone defects is to restore the physiological structure and function of bone as quickly and completely as possible. [0003] At present, methods such as autologous bone grafting, allogeneic bone grafting, and biomaterial implantation are often used to repair bone defects. Autologous bone transplantation is a commonly used clinical method for...

Claims

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Application Information

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IPC IPC(8): A61L27/32A61L27/06A61L27/56
Inventor 何国郝勇强刘萍王楠倪嘉桦吴鲁海
Owner SHANGHAI JIAO TONG UNIV
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