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Method for controlling temperature in the production process of seaweed polysaccharide plant empty capsules

A technology of plant hollow capsules and seaweed polysaccharides, which can be used in capsule delivery, drug delivery, and pharmaceutical formulations. It can solve problems such as incomplete grasp of physical and chemical properties, failure to reach the disintegration time limit, and impact on drug absorption, etc., to avoid technical difficulties and investment, extensive market demand, and high-tech content

Inactive Publication Date: 2009-12-09
INST OF OCEANOLOGY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The main reason why the research and production of plant capsules in the applicant's country lags behind other developed countries is that the physical and chemical properties of the main raw materials for preparing plant capsules are not fully grasped (the national invention patent has been applied for), and another important reason is the level of production technology And temperature control technology, temperature is an important parameter to determine the thickness and quality of the capsule shell! Improper temperature selection and control can cause changes in the disintegration time limit of the capsule shell in the body, so it cannot meet the national requirements for the disintegration time limit in the capsule shell and affect the absorption of drugs, etc.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] Mix 7 kg of cellulose hydroxypropyl methyl ether and 2 kg of seaweed polysaccharide as a coagulant aid and dissolve them in 80 kg of hot water at 75°C. After stirring well, add 5ml of 0.5% calcium citrate as a coagulant aid . At this time, dissolve 2 kg of hydrolyzed starch of thermoreversible colloid in 20 kg of water, mix it with the above solution after fully dissolving and heat to 70°C, and keep the equilibrium reaction time of 3 Hour. Stop keeping warm after 3 hours. Control the temperature of the glue solution at 45°C, control the temperature of the glue tray of the semi-automatic plant capsule production line at 32°C, and start dipping the glue to form a film. The automatic mold dips the glue in the glue tray for 4 seconds, flips the plate for 4 seconds, and enters the temperature at 32 ℃, the humidity is 35% in the drying tunnel, the drying time is 2 hours. After drying, the mold with the sample is transferred to the film-forming workshop at a room temperatur...

Embodiment 2

[0062] Mix 10 kg of cellulose hydroxypropyl methyl ether and 3 kg of seaweed polysaccharide as a coagulant aid and dissolve them in 80 kg of hot water at 90°C. After stirring well, add 5ml of 0.5% calcium citrate as a coagulant aid . At this time, dissolve 3 kg of hydrolyzed starch of thermoreversible colloid in 20 kg of water, mix well with the above solution after fully dissolving, and heat to 80°C. Under the condition that the equilibrium reaction temperature of the glue solution is maintained at 80°C, the equilibrium reaction time is maintained for 2 Hour. Stop keeping warm after 2 hours. Control the temperature of the glue solution at 55°C, control the temperature of the glue tray of the semi-automatic vegetable capsule production line at 36°C, and start dipping the glue to form a film. The automatic mold dips the glue in the glue tray for 6 seconds, flips the plate for 6 seconds, and enters the temperature at 38 ℃, the humidity is 40% in the drying tunnel, and the dryi...

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Abstract

The invention discloses a temperature control technology and temperature control parameters for all production processes which have significant influences on the production quality of enterprises engaged in the production of hardshell empty capsules, in particular to a method for controlling the temperature in the production process of seaweed polysaccharide plant empty capsules. The method adopts cellulose hydroxypropyl methyl ether as film forming agent, seaweed polysaccharide as film assisting agent, hydrolyzed starch as thermal reversible colloid and calcium citrate as coagulant aid; the dissolution temperature of all raw materials in capsule material is controlled at 70-90 DEG C; the balanced reaction time of solution is within 2-4 hours, and the reaction temperature is 70-80 DEG C; the adhesive film-forming temperature is 45-55 DEG C; the adhesive time is controlled at 3-7 seconds; the humidity of a film forming workshop is controlled to be 30-45 percent, and the temperature in the film forming workshop is 30-36 DEG C; the temperature of a drying channel is controlled at 30-40 DEG C, and the humidity of the drying channel is controlled to be 30-45 percent; and the temperature of a plastic plate is controlled at 32-37 DEG C.

Description

technical field [0001] The invention relates to the temperature control technology in the production and preparation process of seaweed polysaccharide plant hollow capsules; specifically, a method for temperature control in the production process of seaweed polysaccharide plant hollow capsules; it is the application of marine biological technology in the hollow capsule pharmaceutical auxiliary material industry . Background technique [0002] The present invention is an invention patent related to the temperature control technology in the preparation process applied on the basis of the invention patent of seaweed polysaccharide plant capsule special glue. The production process of hollow capsules is relatively complicated, especially the temperature control technology is particularly important, because temperature is the main factor affecting the production of hollow capsules. Generally speaking, the range of temperature control is relatively small, and a small temperature ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61J3/07A61K9/48
Inventor 韩丽君史大永袁毅李敬房国明
Owner INST OF OCEANOLOGY - CHINESE ACAD OF SCI
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