Method for preparing non-enzymatic glucose sensor from nickel nano-particle/carbon nano-fiber composite material

A glucose sensor and carbon nanofiber technology, which is applied in the field of nickel nanoparticle/carbon nanofiber composite materials to prepare non-enzymatic glucose sensors, can solve the problems that the application research of electrospun materials is in its infancy

Inactive Publication Date: 2009-12-16
CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In recent years, with the rapid development of electrospinning technology in the synthesis process, its application fields have gradually expanded to photoelectricity, catalysis, filtration, and medical research. However, the research on the application of electrospun materials in electrochemical sensors is still in its infancy.

Method used

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  • Method for preparing non-enzymatic glucose sensor from nickel nano-particle/carbon nano-fiber composite material
  • Method for preparing non-enzymatic glucose sensor from nickel nano-particle/carbon nano-fiber composite material

Examples

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Effect test

Embodiment 1

[0024] Example 1. Preparation of non-enzymatic glucose sensor by nickel nanoparticle / carbon nanofiber composite

[0025] 1) Preparation of electrospinning solution: 8wt.% polyacrylonitrile and 3wt.% nickel acetylacetonate were dissolved in the solvent dimethylformamide to obtain a uniform mixed solution;

[0026] 2) Electrospinning process: the homogeneous mixed solution obtained in step 1) is electrospun under an electric field strength of 80kV / m, the distance between the spinneret and the collecting plate is 20cm, and the applied voltage is 20kV, thereby obtaining polypropylene Nitrile / nickel acetylacetonate composite fiber;

[0027] 3) annealing the composite fiber obtained in step 2) at 200° C. for 2 hours, thereby partially oxidizing the polyacrylonitrile fiber;

[0028] 4) Raise the temperature to 200°C at a rate of 1°C / min, and keep at this temperature for 1h in a nitrogen environment to stabilize the fiber morphology;

[0029] 5) Raise the temperature to 400°C at a r...

Embodiment 2

[0039] Example 2. Preparation of non-enzymatic glucose sensor by nickel nanoparticle / carbon nanofiber composite

[0040] 1) Preparation of electrospinning solution: 10wt.% polyacrylonitrile and 5wt.% nickel acetylacetonate were dissolved in the solvent dimethylformamide to obtain a uniform mixed solution;

[0041] 2) Electrospinning process: the homogeneous mixed solution obtained in step 1) is electrospun under an electric field strength of 100kV / m, the distance between the spinneret and the collecting plate is 30cm, and the applied voltage is 30kV, thereby obtaining polypropylene Nitrile / nickel acetylacetonate composite fiber;

[0042] 3) annealing the composite fiber obtained in step 2) at 230° C. for 3 hours, thereby partially oxidizing the polyacrylonitrile fiber;

[0043] 4) Raise the temperature to 300°C at a rate of 2°C / min, and keep at this temperature for 2 hours in a nitrogen environment to stabilize the fiber morphology;

[0044] 5) Heating up to 500°C at a rate ...

Embodiment 3

[0053] Example 3, Nickel Nanoparticle / Carbon Nanofiber Composite Preparation of Non-enzymatic Glucose Sensor

[0054] 1) Preparation of electrospinning solution: 12wt.% polyacrylonitrile and 7wt.% nickel acetylacetonate were dissolved in the solvent dimethylformamide to obtain a uniform mixed solution;

[0055] 2) Electrospinning process: the homogeneous mixed solution obtained in step 1) is electrospun under an electric field strength of 120kV / m, the distance between the spinneret and the collecting plate is 40cm, and the applied voltage is 40kV, thereby obtaining polypropylene Nitrile / nickel acetylacetonate composite fiber;

[0056] 3) annealing the composite fiber obtained in step 2) at 250° C. for 4 hours, thereby partially oxidizing the polyacrylonitrile fiber;

[0057] 4) Raise the temperature to 400°C at a rate of 3°C / min, and keep at this temperature for 3 hours in a nitrogen environment to stabilize the fiber morphology;

[0058] 5) The temperature was raised to 600...

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Abstract

The invention relates to a method for preparing a non-enzymatic glucose sensor from a nickel nano-particle / carbon nano-fiber composite material, and belongs to the technical field of electrochemical sensors. The nickel nano-particle / carbon nano-fiber composite material is synthesized through electrospinning technology, and is used to prepare the non-enzymatic glucose sensor. The preparation method has low cost, and is simple and quick without intervention of any enzyme. The prepared sensor has high sensitivity, quick response, good stability and certain interference resistance, has a linear range of between 2.0 mu meters and 2.5 millimeters for detecting glucose with limit of detection of 1.0 mu meter. The non-enzymatic glucose sensor prepared by the method has wide application to diabetes mellitus diagnosis and food technology monitoring.

Description

technical field [0001] The invention relates to a method for preparing a non-enzymatic glucose sensor from a nickel nanoparticle / carbon nanofiber composite material. Background technique [0002] Glucose sensors are widely used in the diagnosis of diabetes and the monitoring of food processes. For decades, there has been an increasing demand for glucose sensors with high sensitivity, fast response, good stability, and low cost. Since the enzyme electrode first came out in 1962 (ClarkJr.et al., Ann.N.Y.Acad.Sci., 1962, 102, 29-45.), the method of immobilizing glucose oxidase on the surface of the electrode to construct an electrochemical biosensor has been occupy a dominant position in this field. This type of enzyme sensor has good selectivity and high sensitivity. However, due to the poor chemical and thermal stability of the enzyme itself and the relatively cumbersome immobilization process of the enzyme, its application has certain limitations. For this reason, people ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/413D01D1/02D01D5/00
Inventor 由天艳刘阳
Owner CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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