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Dexamethasone sodium phosphate injection

A technology of dexamethasone sodium phosphate and injection, which can be used in drug delivery, organic active ingredients, antipyretics, etc., and can solve problems such as harm

Active Publication Date: 2010-01-13
TIANJIN JINYAO GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although compared with the prior art, the consumption of propylene glycol has been reduced, but there are still potential hazards in long-term large-scale use, or for people with sensitive constitutions

Method used

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  • Dexamethasone sodium phosphate injection
  • Dexamethasone sodium phosphate injection

Examples

Experimental program
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Effect test

Embodiment 1

[0038] Example 1 Preparation of Injection

[0039] Dexamethasone Sodium Phosphate 5g

[0040] Disodium hydrogen phosphate 1g

[0041] Dissolve the prescribed amount of dexamethasone sodium phosphate in an appropriate amount of water for injection, add the prescribed amount of phosphate buffer, stir evenly, and adjust the pH to 8.0. Add water for injection to 1000ml, filter, subpackage, and sterilize to obtain an injection containing 5 mg of dexamethasone sodium phosphate per ml.

Embodiment 2

[0043] Dexamethasone Sodium Phosphate 1g

[0044] Disodium hydrogen phosphate 1g

[0045]Sodium dihydrogen phosphate 0.05g

[0046] Dissolve the prescribed amount of dexamethasone sodium phosphate bulk drug in an appropriate amount of water for injection, add the prescribed amount of phosphate buffer, adjust the pH to 8.0, add water for injection to 1000ml, filter, subpackage, and sterilize to obtain injections per ml Contains dexamethasone sodium phosphate 1mg.

Embodiment 3

[0048] Dexamethasone Sodium Phosphate 2g

[0049] Disodium hydrogen phosphate 1g

[0050] Sodium dihydrogen phosphate 0.1g

[0051] Dissolve the prescribed amount of dexamethasone sodium phosphate raw material in an appropriate amount of water for injection, add the prescribed amount of phosphate buffer, adjust the pH to 8.0, add water for injection to 1000ml, filter, subpackage, and sterilize to obtain an injection containing Dexamethasone sodium phosphate 2 mg.

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Abstract

The invention provides a dexamethasone sodium phosphate injection, which consists of 0.1 to 1 percent of dexamethasone sodium phosphate, 0 to 2 percent of medicinal propylene glycol, sodium dihydrogen phosphate: disodium hydrogen phosphate=0.01 to 0.1 percent of mixed phosphate buffer according to a ratio of 0-1:10, and the balance of water for injection, wherein the used dexamethasone sodium phosphate bulk medicament preferably selects a spray drying method to produce.

Description

Technical field: [0001] The invention relates to a corticosteroid preparation, especially a preparation containing dexamethasone sodium phosphate. Background technique: [0002] Dexamethasone sodium phosphate (DEXAMETHASONE SODIUM PHOSPHATE, referred to as "de sodium") is an adrenocortical hormone drug. It has anti-inflammatory, anti-allergic, anti-rheumatic and immunosuppressive effects, and is widely used in the treatment of allergic and autoimmune inflammatory diseases. Such as connective tissue disease, active rheumatism, rheumatoid arthritis, lupus erythematosus, severe bronchial asthma, severe dermatitis, ulcerative colitis, acute leukemia, etc. It is also used for some serious infections, poisoning, and malignant lymphoma. treat. The common dosage form is sodium desalination injection. Due to the different production processes of desalination, the excipients used in the formulations of domestic and foreign desalination injections are also different. For example, th...

Claims

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Application Information

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IPC IPC(8): A61K31/661A61K31/573A61K9/08A61P29/00A61P37/00
Inventor 林立生王虹于润芳林劼孙亮陈松赵琳
Owner TIANJIN JINYAO GRP
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