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15 kinds of compound amino acid liquid preparations and preparation method thereof

A compound amino acid and liquid preparation technology, which is applied in 15 kinds of compound amino acid liquid preparations and its preparation field, can solve the problems affecting the health of the infusion population, allergies, pyrogens, tumor-like reactions, pollution particles and impurities, etc., to improve aseptic Guaranteed level, reduced microbial contamination level, reduced effect of introduction of impurities

Active Publication Date: 2011-12-07
上海华源药业(宁夏)沙赛制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because activated carbon is charged, it will be dispersed in water for injection to form a colloidal solution after entering the liquid, which can pass through the filter rod and filter membrane, so that the preparation is contaminated with new particulate impurities, which cannot be metabolized in the body, so it may cause granuloma. , Pulmonary edema, phlebitis, thrombosis, tissue necrosis, allergies, pyrogens, tumor-like reactions and other reactions, there are potential hazards that seriously affect the health of the infusion population

Method used

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  • 15 kinds of compound amino acid liquid preparations and preparation method thereof
  • 15 kinds of compound amino acid liquid preparations and preparation method thereof
  • 15 kinds of compound amino acid liquid preparations and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Embodiment 1: the preparation of 15 kinds of compound amino acid injections (1000ml)

[0050] One, the preparation of 15 kinds of compound amino acid injections

[0051] Weigh various amino acid raw materials and auxiliary materials according to the following Table 1, fill the pharmaceutical sterile bag with nitrogen to replace the oxygen in the bag before and after packaging, and seal it under the protection of nitrogen.

[0052] Table 1, the dosage of each amino acid in the injection

[0053] Labeled amount (mg / ml)

L-proline (C 5 h 9 NO 2 )

8.0 grams

8.0

L-serine (C 3 h 7 NO 3 )

5.0 grams

5.0

L-alanine (C 3 h 7 NO 2 )

7.7 grams

7.7

L-Arginine (C 6 h 14 N 4 o 2 )

6.0 grams

6.0

L-histidine (C 6 h 9 N 3 o 2 )

2.4 grams

2.4

L-tryptophan (C 11 h 12 N 2 o 2 )

0.66 grams

0.66

L-valine (C 5 h 11 NO 2 )

8....

Embodiment 2

[0112] Embodiment 2: the preparation of 15 kinds of compound amino acid injections (1000ml)

[0113] One, the preparation of 15 kinds of compound amino acid injections

[0114] Weigh various amino acid raw materials and auxiliary materials according to the table below, fill the pharmaceutical sterile bag with nitrogen to replace the oxygen in the bag before and after packaging, and seal it under the protection of nitrogen.

[0115] Table 2, the dosage of each amino acid in the injection

[0116] Labeled amount (mg / ml)

L-proline (C 5 h 9 NO 2 )

7.2 grams

7.2

L-serine (C 3 h 7 NO 3 )

4.5 grams

4.5

L-alanine (C 3 h 7 NO 2 )

6.93 grams

6.93

L-Arginine (C 6 h 14 N 4 o 2 )

5.4 grams

5.4

L-histidine (C 6 h 9 N 3 o 2 )

2.16 grams

2.16

L-tryptophan (C 11 h 12 N 2 o 2 )

0.60 grams

0.60

L-valine (C 5 h 11 NO 2 )

7.56...

Embodiment 3

[0153] Embodiment 3: the preparation of 15 kinds of compound amino acid injections (1000ml)

[0154] One, the preparation of 15 kinds of compound amino acid injections

[0155] Weigh various amino acid raw materials and auxiliary materials according to the table below, fill the pharmaceutical sterile bag with nitrogen to replace the oxygen in the bag before and after packaging, and seal it under the protection of nitrogen.

[0156] Table 3, the dosage of each amino acid in the injection

[0157] Labeled amount (mg / ml)

L-proline (C 5 h 9 NO 2 )

8.8 grams

8.8

L-serine (C 3 h 7 NO 3 )

5.5 grams

5.5

L-alanine (C 3 h 7 NO 2 )

8.47 grams

8.47

L-Arginine (C 6 h 14 N 4 o 2 )

6.6 grams

6.6

L-histidine (C 6 h 9 N 3 o 2 )

2.64 grams

2.64

L-tryptophan (C 11 h 12 N 2 o 2 )

0.73 grams

0.73

L-valine (C 5 h 11 NO 2 )

9.24 g...

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Abstract

The invention discloses a liquid preparation of 15 compound amino acids and a preparation method thereof. The method comprises the following steps: dissolving 15 kinds of compound amino acids and an antioxidant in water for injection, mixing them uniformly to obtain solution I, and then filtering the solution I to obtain 15 kinds of compound amino acid liquid preparations. The preparation method of 15 kinds of compound amino acid injections of the present invention adopts preparation methods such as grouping, dissolving in different temperature sections and replacing oxygen with high-purity nitrogen, and overcomes the relatively large change in the color and light transmittance of the finished solution in the existing preparations during storage. Large and many adverse reaction factors. The method of the invention has simple process, is convenient for production operation and control, and is suitable for large-scale production.

Description

technical field [0001] The invention relates to a liquid preparation of 15 compound amino acids and a preparation method thereof. Background technique [0002] Chronic liver disease is a chronic wasting disease, which can cause the disorder of nutritional metabolism in patients. Therefore, malnutrition is very common in patients with chronic liver disease. Among the malnutrition that occurs, "protein-energy malnutrition" is the most common type. [0003] Malnutrition is very common in patients with chronic liver disease, and it is closely related to liver dysfunction, attack rate and mortality. Therefore, nutritional therapy for patients with chronic liver disease has become a clinical necessity, and amino acid preparations specially designed for patients with liver disease can well correct various metabolic complications caused by improper protein intake. [0004] To provide amino acids to patients with liver diseases, ordinary balanced amino acids cannot be used, and mus...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4172A61K31/198A61K31/197A61K31/195A61K31/405A61K31/401A61K9/08A61P3/02
Inventor 刘伟强芦莉娜侯辉
Owner 上海华源药业(宁夏)沙赛制药有限公司
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