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Method for preparing anti-dengue fever oral preparation by applying medicament-loaded nano-magnetic microspheres

An anti-dengue oral agent and magnetic microsphere technology, which can be used in antiviral agents, pharmaceutical formulations, and resistance to vector-borne diseases, etc., can solve problems such as ineffective treatment methods, prevent replication and RNA transcription processes, and improve drug concentration. , the effect of prolonging the half-life

Inactive Publication Date: 2010-01-27
黄云清
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, there is no specific drug or effective treatment for this disease in the world. Generally, symptomatic maintenance treatment is adopted, such as bed rest, physical cooling, maintenance of water and electricity balance, and hemostatic drugs, etc.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] The method for preparing an anti-dengue oral agent by using drug-loaded nano magnetic microspheres is as follows:

[0033] 1. Material preparation: Prepare carrier materials, framework materials, drugs and solvents, among which, the carrier materials are nano-magnetic biomaterials, that is, Fe with particle diameters between 2 and 20 nm 3 o 4 Powder, the skeleton material is β-cyclodextrin, the drugs include artemisinin extract, hypericin extract, buffalo horn extract and turtle shell extract, the solvent is water with a pH value of 6-7 and 50 % ethanol, wherein the weight share of artemisinin extract powder is 10 parts, the weight share of hypericin extract powder is 10 parts, the weight share of buffalo horn extract powder is 10 parts, and the weight share of turtle shell extract powder The weight share is 10 parts;

[0034] 2. Preparation of water-soluble traditional Chinese medicine inclusion microspheres: add β-cyclodextrin, hypericin, and turtle shell extract of...

Embodiment 2

[0038] The method for preparing an anti-dengue oral agent by using drug-loaded nano magnetic microspheres is as follows:

[0039] 1. Material preparation: Prepare carrier materials, framework materials, drugs and solvents, among which, the carrier materials are nano-magnetic biomaterials, that is, Fe with particle diameters between 2 and 20 nm 3 o 4 Powder, the skeleton material is β-cyclodextrin, the drugs include artemisinin extract, hypericin extract, buffalo horn extract and turtle shell extract, the solvent is water with a pH value of 6-7 and 95 % ethanol, wherein the weight share of artemisinin extract powder is 30 parts, the weight share of hypericin extract powder is 30 parts, the weight share of buffalo horn extract powder is 30 parts, and the weight share of turtle shell extract powder The weight share is 30 parts;

[0040] 2. Preparation of water-soluble traditional Chinese medicine inclusion microspheres: add β-cyclodextrin, hypericin, and turtle shell extract of...

Embodiment 3

[0044] The method for preparing an anti-dengue oral agent by using drug-loaded nano magnetic microspheres is as follows:

[0045] 1. Material preparation: Prepare carrier materials, framework materials, drugs and solvents, among which, the carrier materials are nano-magnetic biomaterials, that is, Fe with particle diameters between 2 and 20 nm 3 o 4 Powder, the skeleton material is β-cyclodextrin, the drugs include artemisinin extract, hypericin extract, buffalo horn extract and turtle shell extract, the solvent is water with a pH value of 6-7 and 80 % ethanol, wherein the weight share of artemisinin extract powder is 20 parts, the weight share of hypericin extract powder is 20 parts, the weight share of buffalo horn extract powder is 20 parts, and the weight share of turtle shell extract powder The weight share is 20 parts;

[0046] 2. Preparation of water-soluble traditional Chinese medicine inclusion microspheres: add β-cyclodextrin, hypericin, and turtle shell extract of...

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Abstract

The invention discloses a method for preparing an anti-dengue fever oral preparation by applying medicament-loaded nano-magnetic microspheres, which comprises main process flow such as stock preparation, the preparation of water-soluble Chinese medicament inclusion microspheres, the preparation of alcohol-soluble Chinese medicament inclusion microspheres, and the preparation of water-soluble chemical medicament inclusion microspheres and the like. The method takes beta-cyclodextrin as a framework material, and includes a nano-magnetic biomaterial (carrier material) and a pharmaceutical composition; and the medicament-loaded nano-magnetic microspheres can be quickly combined with target cells, penetrate target cell membranes to enter the cells, realize the transmembrane transport of medicament molecules, achieve targeted release and sustained release effects, improve the medicament concentration in the target cells, inhibit the gene expression and amplification of the target cells to ensure that the target cells degenerate, necrotize or apoptosize, and achieve the effect of the reversal of medicament resistance at the same time. The anti-dengue fever oral preparation prepared by the method prevents the processes of DNA replication and RNA transcription of dengue fever viruses, inhibits remia virusemia caused by the dengue fever viruses, relives pain and reduces fever, and has quick rehabilitation.

Description

technical field [0001] The present invention relates to a new type of anti-dengue fever medicine and its preparation method, especially the anti-dengue fever oral agent prepared by the new preparation technology of drug-loaded nano-magnetic particles using β-cyclodextrin inclusion nano-magnetic biomaterials and medicines; preventing dengue virus DNA The process of replication and RNA transcription can curb the viremia caused by dengue virus, relieve pain and reduce fever, and achieve drug resistance reversal. Background technique [0002] Dengue fever is an acute infectious disease caused by dengue virus and transmitted by Aedes mosquitoes. The clinical features are sudden onset, high fever, muscle, bone marrow and joint pain all over the body, extreme fatigue, and some patients may have rash, bleeding tendency and enlarged lymph nodes. The disease has been prevalent in my country's Guangdong, Guangxi, and Hainan, and it is found all year round in Southeast Asia. There are ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/56A61K31/7056A61K9/16A61K9/28A61K9/48A61K47/02A61K47/40A61P31/14A61K31/122A61K31/357A61K31/522A61K35/32A61K35/586
CPCY02A50/30
Inventor 黄云清
Owner 黄云清