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Nano diglyceride microemulsion carrier and preparation method thereof

A technology of diglyceride and microemulsion, which is applied in the field 1, can solve the problems of large emulsion particles, thermodynamic instability, and low bioavailability, and achieve the effects of improving dispersion, wide dilution range, and expanding the application range

Inactive Publication Date: 2010-04-07
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Diacylglycerol is a kind of oil, which is insoluble in water and has a large molecular weight. In the actual production and application of food, to make it fully dissolved and dispersed in water, it can be considered to be made into an ordinary emulsion, but it is well known that ordinary emulsions It is a thermodynamically unstable system, which is prone to oil-water stratification during storage, which not only affects the appearance of the product, but also affects the bioavailability of the product, and the emulsion particles are relatively large, and the bioavailability is not high. Therefore, it is necessary to invent A more stable diglyceride delivery system that can improve the bioavailability of diglyceride to expand the application range of diglyceride in food

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Embodiment 1, a kind of preparation method of nano diglyceride microemulsion carrier, carries out following steps successively:

[0019] 1), take by weight 25 parts of 1,3-diglyceride, 6.25 parts of polyoxyethylene sorbitan monooleate, 3.12 parts of polyoxyethylene sorbitan monolaurate, 6.25 parts of no Water ethanol, 8 parts of glycerin, 16 parts of sucrose, 35.38 parts of distilled water.

[0020] 2), first dissolving glycerol and sucrose in distilled water for subsequent use; then 1,3-diglyceride, polyoxyethylene sorbitan monooleate, polyoxyethylene sorbitan monolaurate Mix with absolute ethanol at 25°C and stir evenly (stirring for 2 minutes), then keep the temperature at 25°C, and slowly add (1 drop / 2 minutes) the above spare distilled water dissolved in glycerol and sucrose, stirring while adding (2400 rev / min), and the transparent nano-diglyceride microemulsion carrier is obtained after the dropwise addition.

[0021] In order to prove the advantages of the pre...

Embodiment 2

[0028] Embodiment 2, a kind of preparation method of nano diglyceride microemulsion carrier, carries out following steps successively:

[0029] 1), take by weight 25 parts of 1,3-diglyceride, 6.25 parts of polyoxyethylene sorbitan monooleate, 1.56 parts of sorbitan monooleate, 5 parts of absolute ethanol, 13 parts of glycerin, 49.19 parts of distilled water.

[0030] 2), first dissolve glycerol in distilled water for later use; then mix 1,3-diglyceride, polyoxyethylene sorbitan monooleate, sorbitan monooleate and absolute ethanol After stirring evenly at 25°C, keep the temperature at 25°C, slowly add dropwise (1 drop / 2 minutes) the above-mentioned spare distilled water dissolved in glycerin, stir while adding, and obtain transparent nano-glycerol di Ester microemulsion carrier.

[0031] The nano diglyceride microemulsion carrier of embodiment 2 gained carries out following experiment respectively:

[0032] Experiment 2.1 Stability test

[0033] The above-mentioned nano-dig...

Embodiment 3

[0038] Embodiment 3, a kind of preparation method of nano diglyceride microemulsion carrier, carries out following steps successively:

[0039] 1), take by weight 28 parts of 1,3-diglyceride, 2.8 parts of polyoxyethylene sorbitan monooleate, 1.4 parts of sorbitan monolaurate, 2.66 parts of polyoxyethylene sorbitan monolaurate, Sorbitan monolaurate, 7 parts absolute ethanol, 18 parts sucrose, 40.14 parts distilled water.

[0040]2), first dissolve sucrose in distilled water for later use; then 1,3-diglyceride, polyoxyethylene sorbitan monooleate, sorbitan monolaurate, polyoxyethylene sorbitan Mix alcohol anhydride monolaurate and absolute ethanol at 29°C and stir evenly, keep the temperature at 29°C, slowly add the above-mentioned spare distilled water dissolved in sucrose dropwise, stir while adding, and obtain transparent nano Diacylglycerol microemulsion carrier.

[0041] The nano diglyceride microemulsion carrier of embodiment 3 gained carries out following experiment res...

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Abstract

The invention discloses a nano diacylglycerol microemulsion carrier, which consists of the following compositions in percentage by weight: 25 to 30 percent of 1,3-sn-diacylglycerols, 6.5 to 11.5 percent of surfactant, 5 to 7.5 percent of cosurfactant, 10 to 25 percent of cosolvent and the balance of distilled water which is over 25 percent. The invention also discloses a method for preparing the nano diacylglycerol microemulsion carrier, which comprises the following steps: evenly stirring and mixing the surfactant, the cosurfactant and the 1,3-sn-diacylglycerols at a temperature between 20 and 30 DEG C; and maintaining the temperature between 20 and 30 DEG C, dropwise adding the distilled water in which the cosolvent is dissolved with stirring, and obtaining the nano diacylglycerol microemulsion carrier after the dropwise addition is finished. The nano diacylglycerol microemulsion carrier can be dissolved in water, and has good stability and high bioavailability.

Description

technical field [0001] The invention belongs to the field of food and relates to a microemulsion which can be added to other foods to form a new product, in particular to a microemulsion carrier with 1,3-diglyceride as an oil phase and a preparation method thereof. Background technique [0002] Diacylglycerol is a small amount naturally occurring in edible vegetable oils, and it has two isomers (1,2-diglyceride and 1,3-diglyceride). Multiple safety assessments on 1,3-diglyceride found that 1,3-diglyceride is non-toxic and harmless to the human body, and has been identified as a "generally recognized safe" substance by the US FDA. Although 1,3-diglycerides and triglycerides (the main components of natural oils) are basically the same in terms of energy value and absorption rate, there are large differences in their metabolism in the body. Short-term and long-term animal and human experiments have shown that , Compared with triglycerides containing the same or similar fatty a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L1/30A23L33/115A23P10/35
Inventor 李铎陈莹张辉
Owner ZHEJIANG UNIV
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