Preparation method for feed additive dihydropyridine

A feed additive, dihydropyridine technology, applied in the field of medicine and chemical industry, can solve the problems of short reaction time, high energy consumption and high cost, and achieve the effects of short reaction time, low cost and high benefit

Active Publication Date: 2010-05-12
HUNAN NEW WELLFUL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method has short reaction time and high yield, but the isopropanol solvent needs to be evaporated, and the energy consumption cost is high

Method used

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  • Preparation method for feed additive dihydropyridine
  • Preparation method for feed additive dihydropyridine

Examples

Experimental program
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Effect test

example 1

[0019] A kind of preparation method of feed additive dihydropyridine, its steps are:

[0020] 1. Put 1 mole of ethyl acetoacetate and 1 mole of formaldehyde with a concentration of 40% by weight into a reaction kettle equipped with a reflux condenser, stir and dissolve at 25 or 28 or 30 or 32 or 34 or 35 ° C, add 95% ethanol with a percentage concentration of 1 times the weight ratio, controlled temperature at 60° C., and reacted for 1 hour to obtain liquid A.

[0021] 2. Put 1 mole of ethyl acetoacetate and 2 moles of ammonium bicarbonate into a reaction kettle equipped with a reflux condenser, add 95% ethanol with a weight ratio of 1 times, control the temperature at 60°C, and react for 1 hour to obtain liquid B .

[0022] 3. Put liquid A and liquid B into a reaction kettle equipped with a reflux condenser, add 50 grams of sodium hydroxide, control the reaction temperature at 60°C, react for 1 hour, cool and precipitate crystals, filter, and dry the filter cake at 80°C for ...

example 2

[0024] A kind of preparation method of feed additive dihydropyridine, its steps are:

[0025] 1. Put 1 mole of ethyl acetoacetate and 1.5 moles of formaldehyde with a concentration of 40% by weight into a reaction kettle equipped with a reflux condenser, stir and dissolve at 25 or 27 or 39 or 31 or 33 or 35 ° C, add the weight ratio 1.5 times the percentage concentration of 95% ethanol, control the temperature at 65°C, and react for 1.5 hours to obtain liquid A.

[0026] 2. Put 1 mole of ethyl acetoacetate and 2.5 moles of ammonium bicarbonate into a reaction kettle equipped with a reflux condenser, add 95% ethanol with a weight ratio of 1.5 times, control the temperature at 65° C., and react for 1.5 hours to obtain B liquid.

[0027] 3. Put liquid A and liquid B into a reaction kettle equipped with a reflux condenser, add 60 grams of sodium hydroxide, control the reaction temperature at 65°C, react for 1.5 hours, cool and precipitate crystals, filter, and dry the filter cake...

example 3

[0029] A kind of preparation method of feed additive dihydropyridine, its steps are:

[0030] 1. Put 1 mole of ethyl acetoacetate and 2 moles of formaldehyde with a concentration of 40% by weight into a reaction kettle equipped with a reflux condenser, stir and dissolve at 25 or 26 or 29 or 31 or 33 or 35 ° C, add the weight ratio 2 times the percentage concentration of 95% ethanol, controlled temperature 70°C, reacted for 1.5 hours to obtain liquid A.

[0031] 2. Put 1 mole of ethyl acetoacetate and 3 moles of ammonium bicarbonate into a reactor equipped with a reflux condenser, add 95% ethanol with a percentage concentration of 2 times the weight ratio, control the temperature at 70° C., and react for 1.5 hours to obtain B liquid.

[0032] 3. Put liquid A and liquid B into a reaction kettle equipped with a reflux condenser, add 70 grams of sodium hydroxide, control the reaction temperature at 70°C, react for 2 hours, cool and precipitate crystals, filter, and dry the filter...

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Abstract

The invention discloses a preparation method for feed additive dihydropyridine. The method comprises the following steps of: a, putting ethyl acetoacetate and formaldehyde of 40 percent into a reaction kettle provided with a reflux condenser; stirring, mixing and dissolving the materials at a normal temperature, and adding ethanol to perform reaction to obtain a solution A; b, putting the ethyl acetoacetate and ammonia water into the reaction kettle provided with the reflux condenser, and adding the ethanol to perform reaction to obtain a solution B; and c, putting the solution A and the solution B into the reaction kettle provided with the reflux condenser, adding sodium hydroxide, and carrying out reacting, cooling, crystallizing, filtering and drying to obtain the dihydropyridine. The obtained dihydropyridine is applied to livestock and poultry feeds, can improve the fecundation (fertilization) rate, the hatchability, the laying rate, the milk yield and the daily gain of livestock and poultry and the feed returns, and can reduce the feeding cost. The dihydropyridine is a multifunctional feed additive with small usage and high efficiency and has a wide application prospect.

Description

technical field [0001] The invention relates to the technical field of medicine and chemical industry, and more specifically relates to a preparation method of a feed additive dihydropyridine. Dihydropyridine is a new type of multifunctional feed additive. It is usually used as a preventive and health care drug for cardiovascular diseases in medicine. It has the effects of treating fatty liver, toxic hepatitis, and anti-aging. It can also act as an antioxidant in fats. Background technique [0002] The preparation method of the pyridine ring system is the Han Qi synthesis method, which is prepared by condensation of two molecules of β-hydroxy acid ester, one molecule of aldehyde and one molecule of ammonia. The reaction process is that one molecule of β-hydroxy acid ester and one molecule of aldehyde generate α-acyl alkenoate, and another molecule of β-hydroxy acid ester and ammonia generates β-amino alkenoate: [0003] [0004] The two compounds then undergo a Pearl re...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D211/90
Inventor 印遇龙谭碧娥黄瑞林
Owner HUNAN NEW WELLFUL CO LTD
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