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Plant empty capsule, soft capsule composition and preparation methods thereof

A technology of vegetable capsules and hollow capsules, which can be used in capsule delivery, pharmaceutical formulations, drug delivery, etc., and can solve problems such as film-forming stability problems

Inactive Publication Date: 2010-05-19
上海红星胶丸有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the prior art, there are hollow capsules and soft capsules prepared from potatoes or konjac as raw materials, but these products need to be improved because of the problem of film-forming stability.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Embodiment 1: plant hollow capsule

[0045] Raw material parts by weight

[0046] Tapioca starch 500

[0047] Wheat Starch 500

[0048] Gellan Gum 5

[0049] carrageenan 2

[0050] Sucrose 5

[0051] Low-substituted hydroxypropyl methylcellulose 12

[0052] Trisodium Citrate 12

[0053] Polyethylene glycol 6000 10

[0054] Tween 80 20

[0055] water 6000

[0056] Put the starch and plasticizer in the parts by weight in a mixer and mix them thoroughly, then inhale them into a reaction pot filled with 6000 parts by weight of water at 95°C, stir rapidly for 60 minutes, then discharge, and filter with a 100-mesh stainless steel filter , to obtain the plant hollow capsule glue, the glue was kept at 50° C. for 120 minutes, and then put on the capsule automatic production line to make capsules. The prepared hollow capsule has an original density of 10 silk, a head thickness of 13 silk, and a disintegration time of 10 minutes, reaching the standard of the 2000 edition...

Embodiment 2

[0058] Raw material parts by weight

[0059] Cornstarch 1000

[0060] Vegetable capsule special plasticizer 20

[0061] water 5000

[0062] 1000 parts by weight of cornstarch and 20 parts by weight of the prepared special plasticizer are fully mixed in a mixer, inhaled into a reaction pot filled with 5000 parts by weight of water at 95°C, stirred rapidly for 60 minutes, and then discharged. Filter through a 100-mesh stainless steel filter to obtain the glue of plant hollow capsules, keep the glue at 50°C for 120 minutes, and then go to the automatic capsule production line to make capsules. The prepared hollow capsule has an original density of 10.5 silk, a thickness of the head of 15 silk, and a disintegration time of 8 minutes, reaching the standard of the 2000 edition of the Pharmacopoeia.

Embodiment 3

[0064] Raw material parts by weight

[0065] Tapioca starch 500

[0066] Wheat Starch 500

[0067] Vegetable capsule special plasticizer 33

[0068] water 4000

[0069] Put 1,000 parts by weight of tapioca starch and wheat starch as raw materials and 33 parts by weight of the prepared special plasticizer in a mixer and fully mix them, then inhale them into a reaction pot filled with 4,000 parts by weight of water at 95°C, and stir rapidly for 50 minutes The material is discharged and filtered with a 100-mesh stainless steel filter to obtain a vegetable capsule glue, which is kept at 50°C for 120 minutes, and then put on an automatic production line for soft capsules to make capsules. The prepared soft capsule has an original strength of 30 silk and a disintegration time of 21 minutes, reaching the standard of the 2000 edition of the Pharmacopoeia.

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Abstract

The invention relates to an empty capsule formula and a soft capsule formula which take plant starch and a plasticizer as raw materials, and preparation methods thereof, wherein the plant starch is selected from corn starch, wheat starch, potato starch, cassava starch, soluble starch and dextrin pregelatinized starch or compositions thereof, and the content of the plant starch in capsule components is 100 to 2,000 parts by weight; and the plasticizer comprises the following components in part by weight: 1 to 15 parts of gellan gum, 4 to 20 parts of carrageenin, 1 to 5 parts of sucrose acid ester, 1 to 15 parts of low-substituted hydroxypropyl methyl cellulose, 1 to 9 parts of trisodium citrate, 10 to 40 parts of polyethylene glycol 6,000 and 5 to 15 parts of tween-80. The empty capsule and the soft capsule have the following advantages that: the empty capsule and the soft capsule are adaptable to different purposes, are stable in chemical properties, do not react with air and water, are directly discharged out of a human body without being absorbed by the human body, are not easy to grow microgranisms, are not decomposed and deteriorated under normal conditions, have no requirements on storage conditions, are not embrittled at a high temperature and the like.

Description

technical field [0001] The invention relates to a plant starch hollow capsule and soft capsule formula and a preparation method thereof, in particular to a hollow capsule and soft capsule formula and a preparation method using plant starch and a plasticizer as raw materials. Background technique [0002] Vegetable starch hollow capsules and soft capsules, as pharmaceutical excipients, are widely used in canned or packaged medicines, health foods and cosmetics in the form of granules, powders or drops. Present empty capsules and soft capsules are generally made of gelatin and added water. Since the raw material of gelatin comes from animal skin and bone, it belongs to animal protein colloid and contains a small amount of animal fat. After being prepared as hollow capsules or soft capsules with it, people of some beliefs cannot take it. On the other hand, the spread of some animal infectious diseases can cause safety problems in use. Moreover, hollow capsules and soft capsu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K47/36A61K47/38A61J3/07
Inventor 梁贤昌
Owner 上海红星胶丸有限公司
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