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Shendeng 4-decoction target field and preparation method thereof

A technology of effective parts and decoction medicinal materials, applied in the field of medicine, can solve the problems of preparation method and use of effective parts of Sendeng Siwei Decoction, etc.

Active Publication Date: 2010-06-09
董玉 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Sendeng Siwei Decoction mainly contains flavonoids, terpenoids, anthraquinones, alkaloids and other ingredients, but so far there is no patent related to the effective parts of Sendeng Siwei Decoction, its preparation method and use

Method used

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  • Shendeng 4-decoction target field and preparation method thereof
  • Shendeng 4-decoction target field and preparation method thereof
  • Shendeng 4-decoction target field and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0127] Embodiment 1: Preparation of the effective part of Sendeng Siwei Decoction

[0128] Take 1 kg of compound herbal decoction pieces of Sendeng Siwei Tang, reflux extraction with 10L of 70% ethanol twice, extract for 2 hours each time, recover the solvent under reduced pressure to obtain the extract, add a certain volume of water to disperse and dissolve, so that the amount of the medicinal material is the same as that of the dispersed solution The volume ratio is 1:3.5. Through 7.5LAB-8 macroporous adsorption resin, the adsorption flow rate is 2Bv / h, the ratio of resin column diameter to height is 1:10, and 1.5 times the resin volume is eluted with water for impurity removal, the impurity removal flow rate is 4Bv / h, and 50% ethanol is eluted 8 times the volume of the resin, the elution flow rate is 4Bv / h, collect the 50% ethanol eluate, recover the solvent, and dry under reduced pressure, which is the effective part of Sendeng Siwei Decoction.

Embodiment 2

[0129] Embodiment 2: Preparation of the effective part of Sendeng Siwei Decoction

[0130] Take 1 kg of compound herbal decoction pieces of Sendeng Siwei Decoction, add 15 L of 50% ethanol for ultrasonic extraction 3 times, extract for 1.5 hours each time, recover the solvent under reduced pressure to obtain the extract, add a certain volume of water to disperse and dissolve, so that the amount of the medicinal material is the same as that after dispersion The solution volume ratio is 1:5. Through 10L AB-8 macroporous adsorption resin, the adsorption flow rate is 2Bv / h, the diameter-to-height ratio of the resin column is 1:12, and the water is eluted to 2 times the volume of the resin for impurity removal. The impurity removal flow rate is 4Bv / h, and 50% ethanol is eluted 7 times the volume of the resin, the elution flow rate is 4Bv / h, collect the 50% ethanol eluate, recover the solvent, and dry under reduced pressure, which is the effective part of Sendeng Siwei Decoction.

Embodiment 3

[0131] Embodiment 3: Preparation of the effective part of Sendeng Siwei Decoction

[0132] Add 50% methanol to 1 kg of compound medicinal materials of Sendeng Siwei Decoction, and extract by microwave three times, each time for 1 hour, with a solvent dosage of 10 L. Add the extract to a certain volume of distilled water, so that the volume ratio of the amount of medicinal materials to the solution after dispersion is 1 : 8, then centrifuged for 35 minutes at a speed of 4000 revs / min, poured out the supernatant, the precipitate was refluxed 2 times with ethanol as 3BV in terms of crude drug amount, each 1.5 hours, combined the ethanol extract, reclaimed the solvent, The residue is the effective part of Sendeng Siwei Tang.

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Abstract

The invention discloses a Shendeng 4-decoction target field and a preparation method thereof. The preparation method comprises one or more of the precipitation method, the liquid-liquid counter-current distribution chromatography and the macropore adsorbent resin method and greatly increases the content of effective ingredients of Shendeng 4-decoction by purifying and enriching extracts of bulk drugs of the Shendeng 4-decoction.At the same time, the invention also discloses a method for detecting the Shendeng 4-decoction target field, which determines the contents of total flavone, quercetinic acid, total terpene and jasminoidin contained in the Shendeng 4-decoction target field and is beneficial to enhancing the stability of the product, thereby having the practical significance for the development of the Mongolian drug Shendeng 4-decoction.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to an effective part of Sendeng Siwei Decoction, a preparation method, a detection method thereof, and an application in the fields of medicine and health food. Background technique [0002] Sendeng Siwei Decoction is composed of 4 medicinal materials such as Wenguanmu (called Sendeng in Mongolia), Gardenia, Myrobalan, and Toosendan. It is commonly used in Mongolian medicine. It has the function of clearing away heat and dampness. It is used to treat various Arthritis, edema. Traditional Mongolian medicine theory believes that Sendeng Siwei Decoction has the functions of clearing away heat, drying "Xie Ri Wu Su" and reducing swelling. It is mainly used for gout, arthralgia, joint jaundice, and edema. Sendeng Siwei Decoction mainly contains flavonoids, terpenoids, anthraquinones, alkaloids and other ingredients, but so far there is no patent related to the effective parts of Senden...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/77A61P19/02G01N21/31G01N30/02
Inventor 董玉马强
Owner 董玉