Cisplatin spinal tumor slow-release implant and preparation method thereof

A technology for slow-release implants and spinal tumors, which is applied in the direction of anti-tumor drugs, pharmaceutical formulations, and medical preparations of non-active ingredients, etc. The effect of survival time
CN101732345AInactive Publication Date: 2010-06-16SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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Patent Information

Authority / Receiving Office
CN Β· China
Current Assignee / Owner
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
Publication Date
2010-06-16
Estimated Expiration
Not applicable Β· inactive patent

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Abstract

The invention belongs to the field of pharmacy, and relates to a controlled-release medicinal preparation, in particular to a cisplatin spinal tumor slow-release implant which takes polylactic acid-glycolic acid copolymer (PLGA) as a carrier and cisplatin as a main medicament for treating the spinal tumor and a preparation method thereof. The weight ratio of the cisplatin to the PLGA is 1:99-40:60. A cisplatin slow-release micro-ball is prepared through reemulsifying-solvent volatilization method, and the micro-ball is tabletted to obtain the cisplatin slow-release implant for interstitial chemotherapty after the spinal tumor and the other tumor surgeries. Experiments prove that: the cumulative medicament release rate of the cisplatin slow-release implant after 38 days can reach 84 percent, the sustained release time in the body can reach 36 days, the local medicament concentration is high and an effect of inhibiting the tumor is obvious.
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Description

technical field

[0001] The invention belongs to the field of pharmacy, and relates to controlled and sustained-release pharmaceutical preparations, in particular to a cisplatin sustained-release implant for treating spinal tumors with polylactic acid-glycolic acid copolymer (PLGA) as a carrier and cisplatin as the main agent. Preparation. Background technique

[0002] Spinal tumor is a relatively special disease among various tumors. With the development and progress of social economy, the incidence and diagnosis rate of spinal tumors are increasing year by year. However, due to the particularity of the anatomical structure of the spine, the complexity of adjacent structures, and the local invasion of spinal tumors, it is extremely difficult to completely and fully remove the tumor tissue, and recurrence or metastasis often occurs after surgery. Therefore, how to prolong the postoperative survival period and improve the quality of life of patients with spinal tumors is sti...

Claims

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