Method for preparing mesoporous material with hydrophobic inner surface and hydrophilic outer surface
What is Al technical title?
Al technical title is built by PatSnap Al team. It summarizes the technical point description of the patent document.
A mesoporous material and outer surface technology, applied in chemical instruments and methods, inorganic chemistry, other chemical processes, etc., to achieve the effect of simple method, improved analysis efficiency, improved screening ability and extraction efficiency
Inactive Publication Date: 2010-06-16
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
View PDF1 Cites 16 Cited by
Summary
Abstract
Description
Claims
Application Information
AI Technical Summary
This helps you quickly interpret patents by identifying the three key elements:
Problems solved by technology
Method used
Benefits of technology
Problems solved by technology
The method is
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more
Image
Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
Click on the blue label to locate the original text in one second.
Reading with bidirectional positioning of images and text.
Smart Image
Examples
Experimental program
Comparison scheme
Effect test
Example Embodiment
[0021] Example 1
[0022] 1) Co-precipitation synthesis of materials:
[0023] Mix with tetraethoxysilane: vinyl triethoxysilane: cetyl trimethyl ammonium bromide: sodium hydroxide: water in a certain molar ratio of 1: 0.25: 0.15: 0.38: 125, The hydrothermal reaction was carried out at 87°C for 2 days. After filtering, washing and drying the material. (References: Lim, M.H.; Blanford, C.F.; Stein, A.J.Am.Chem.Soc. 1997, 119, 4090.)
[0024] 2) External surface modification:
[0025] External surface modification: 1.0 g of the above-synthesized powder was vacuum-dried at 90 °C for 12 hours, the dried material containing the pore-forming agent was added to a round-bottomed flask, and 60 mL of dry toluene was added to the flask under nitrogen protection, After the material was completely dispersed in the dry organic solvent, 3 mL of 3-(2,3-glycidoxy)propyltrimethoxysilane was added, and the reaction was carried out at 100° C. for 24 hours under nitrogen protection. After the...
Example Embodiment
[0028] Example 2
[0029] 1) Co-precipitation synthesis of materials:
[0030] Mix with tetraethoxysilane: vinyl triethoxysilane: cetyl trimethyl ammonium bromide: sodium hydroxide: water in a certain molar ratio of 1: 0.25: 0.15: 0.38: 125, The hydrothermal reaction was carried out at 87°C for 2 days. After filtering, washing and drying the material. (References: Lim, M.H.; Blanford, C.F.; Stein, A.J.Am.Chem.Soc. 1997, 119, 4090.)
[0031] 2) External surface modification:
[0032] External surface modification: 2.0 g of the above-synthesized powder was vacuum-dried at 80 °C for 15 hours, the dried material containing the pore-forming agent was added to a round-bottomed flask, and 100 mL of dry cyclohexane was added to the flask under nitrogen protection alkane, after the material was completely dispersed in dry cyclohexane, 6 mL of 3-(2,3-glycidoxy)propyltrimethoxysilane was added, and the reaction was carried out at 60° C. for 24 hours under nitrogen protection. After ...
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
PUM
Login to view more
Abstract
The invention relates to a method for preparing mesoporous material with the hydrophobic inner surface and the hydrophilic outer surface, comprising the steps of coprecipitating and synthesizing the mesoporous material, modifying the outer surface of the mesoporous material and removing the pore-forming agent. Tetra-alkoxy silicane and siloxane containing hydrophobic functional groups are used as mixed silicon source, the mixed silicon source is hydrolyzed and synthesized into hydrophobic mesoporous material which contains pore forming agent under the alkaline condition, the hydrophobic mesoporous material reacts with the siloxane which contains or can generate the hydrophilic functional groups in methylbenzene under the protection of nitrogen, the products of reaction are extracted by acidified alcohol, and the pore-forming agent is removed. The mesoporous material with the hydrophobic inner surface and the hydrophilic outer surface can greatly reduce the interference of high molecular weight biological matrix in the process of pretreating the sample, improve the protein or peptide screening ability and highly elute and recover the small molecule protein or the small molecule peptide and is suitable for selectively extracting the medicament and the low molecular weight protein in the complex biological matrix.
Description
technical field [0001] The invention relates to a hybrid mesoporous material, in particular to a preparation method for modifying different organic functional groups on the inner and outer surfaces of the pores of the mesoporous silicon material. Background technique [0002] In recent years, there have been reports on the adsorption of drugs and biomolecules based on mesoporous materials, making mesoporous materials develop vigorously in the biological field. In particular, the strictly limited pore size of mesoporous materials is used to selectively extract target molecules that are smaller than the pore size. However, there are certain problems in the selective extraction of mesoporous materials: 1. Although the pore size can strictly limit the entry of large proteins into the pores, the outer surface of the pores can still adsorb molecules with a molecular size larger than the pore size, which are often mistaken for the molecules inside the pores. The adsorption of larg...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
Application Information
Patent Timeline
Application Date:The date an application was filed.
Publication Date:The date a patent or application was officially published.
First Publication Date:The earliest publication date of a patent with the same application number.
Issue Date:Publication date of the patent grant document.
PCT Entry Date:The Entry date of PCT National Phase.
Estimated Expiry Date:The statutory expiry date of a patent right according to the Patent Law, and it is the longest term of protection that the patent right can achieve without the termination of the patent right due to other reasons(Term extension factor has been taken into account ).
Invalid Date:Actual expiry date is based on effective date or publication date of legal transaction data of invalid patent.
Login to view more
IPC IPC(8): B01J20/10B01J20/283B01J20/30
Inventor 祁艳霞关亚风王华朱道乾卢烈娟
Owner DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
Login to view more 
Login to view more