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Preparation process of effective part of flower of abelmoschus manihot-total flavone extractive and new use thereof

A technology of effective parts and hollyhock flowers, applied in the field of biomedicine, can solve the problems that there are no reports on anti-hepatitis B virus and liver protection research.

Active Publication Date: 2011-06-01
HANGZHOU CONBA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The above research data suggest that the flavonoids in hollyhock flowers have a certain effect on the treatment of hepatitis, but there is no research report on the use of total flavonoids in hollyhock flowers for anti-hepatitis B virus and liver protection.

Method used

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  • Preparation process of effective part of flower of abelmoschus manihot-total flavone extractive and new use thereof
  • Preparation process of effective part of flower of abelmoschus manihot-total flavone extractive and new use thereof
  • Preparation process of effective part of flower of abelmoschus manihot-total flavone extractive and new use thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0011] Example 1 Preparation of effective fractions of total flavonoids from hollyhock flower

[0012] Add an appropriate amount of 80% ethanol to the hollyhock flower, extract once, extract for 2 hours, combine the extracts, filter, concentrate the filtrate into a concentrated solution with a relative density of 1.13-1.16 at 60°C, add an appropriate amount of water to sink for 24 hours, and filter with suction. Concentrate to the corresponding volume, pass through a macroporous adsorption resin column, use alcohol-water gradient elution, water elution 3 column volumes, 10% and 30% ethanol each elution 3 column volumes, 70% ethanol elution 1 column volume . The eluate is concentrated, dried and pulverized to obtain the total flavonoid extract of the marshmallow flower, and the total flavonoid content is 65%.

Embodiment 2

[0013] Example 2 Preparation of effective fraction capsules of total flavonoids of marshmallow flowers

[0014] Take 250g of the extract of effective fractions of total flavonoids from hollyhock flowers, 50g of magnesium stearate, pass through an 80-mesh sieve, mix well, dry granulate, fill 1000 capsules, and each capsule contains 250mg of effective fractions from total flavonoids from hollyhock flowers. Usage: 2 capsules each time, three times a day.

Embodiment 3

[0015] Example 3 Preparation of tablets of effective fractions of total flavonoids from hollyhock flowers

[0016] Take 250g of the effective part extract of total flavonoids of hollyhock flower and 45g of microcrystalline cellulose, mix well, wet granulate with ethanol, and pass through a 20-mesh sieve. Add 5 g of magnesium stearate, mix evenly, and press to form 1000 tablets with a tablet weight of 0.3 g / tablet, each containing 250 mg of active parts of total flavonoids from hollyhock flowers. Usage: 2 tablets each time, three times a day.

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Abstract

The invention provides a preparation process of an effective part of flower of abelmoschus manihot-a total flavone extractive and a new use thereof, in particular relating to the use in preparing a medicine for treating hepatitis B.

Description

technical field [0001] The present invention belongs to the field of biomedicine, and in particular refers to a new drug application of effective parts of total flavonoids of hollyhock flowers, specifically the application in the preparation of medicines for treating hepatitis B, including the drug whose active ingredient is the effective parts of total flavonoids of hollyhock flowers Use of the composition in preparing medicine for treating hepatitis B. Background technique [0002] Hollyhock flower is the dry corolla (with stamens and style) of Malvaceae Abelmoschμs manihot (L.) Medic., which is included in the Supplement of "Standards of Traditional Chinese Medicinal Materials of Jiangsu Province" (1989 Edition) and "Standards of Traditional Chinese Medicinal Materials of Shandong Province" 2002 edition. It has the effects of clearing dampness and heat, reducing inflammation and detoxification. It is a traditional medicinal plant in my country. The history of its use as ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/185A61P1/16A61P31/20
Inventor 张玲凌沛学尚立霞曲延伟吴永霞
Owner HANGZHOU CONBA PHARMA