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Antimicrobial composition

一种抗菌组合物、硅质的技术，应用在抗细菌药、药物组合、药物输送等方向，能够解决不能改善组织供血、不够有效、没有抗缺氧和吸附作用等问题

Active Publication Date: 2010-07-07
亚历山大·A·戈卢布
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this preparation is not effective enough in the treatment of purulent complications in soft tissues leading to tissue necrosis, it does not improve blood supply to the tissue, has no anti-hypoxic and adsorptive action

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] 100 mg of Serratothiopeptidase was dissolved in 100 ml of distilled water and stirred at room temperature for 30-60 minutes. Aerosil A-300 was then added to the solution in an amount of 10 g while continuing to stir. The mixture thus obtained was dried under vacuum at a temperature of 30° C. to form a granular white powder.

Embodiment 2

[0021] Dissolve 16 mg of Serratothiopeptidase in 10 ml of distilled water and stir at room temperature for 30-60 minutes. 1 g of fumed silica A-300 (Atoxil) was then added to the solution while continuing to stir. The mixture thus obtained was dried under vacuum at a temperature of 40° C. to form a granular white powder.

[0022] The preparation is indicated for the treatment of ulcerated wounds, third and fourth degree burns, trophic ulcers of various aetiologies, where tissue necrosis usually occurs. The preparation eliminates odor, removes pus and necrotic tissue from the wound.

[0023] It was found that only solutions of serrated thiopeptidase containing not more than 0.5% of active substance should be employed to obtain the formulation Sertasil. The preparation is indicated for the treatment of third- and fourth-degree burns, deep wounds, trophic ulcers with a marked necrotic and exudative component.

[0024] Septasil was used to treat 47 patients with deep trophic ul...

Embodiment 3

[0027] Example 3: Patient K, born in 1935, was admitted to the hospital and diagnosed with chronic venous insufficiency of the lower extremities, complicated by trophic ulcers and covered with necrotic tissue. Found 10 in 1g of tissue sample based on microbiological examination 8 Bacteroides fragilis, Escherichia coli. After two consecutive dressings with SertaSil, no bacteria were found and the ulcer was completely cleared within 3 days. Thereafter, bandage with methyluracil ointment until full recovery within 17 days.

[0028] In view of the above, the new formulation Sertasil can be used in the topical treatment of wounds of various origins, trophic ulcers, abscesses, infiltrations, burns, etc., which for various reasons cannot be removed by other methods, including surgical methods. Element.

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PUM

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Abstract

A complex antimicrobial sorption composition possessing the necrolytic effect for treating the purulent wounds, the trophic ulcers, the wounds, and the infiltrates with the significant necrotic and exudative components represents the silica sorbent with the immobilized drug. Aerosil is used as a siliceous sorbent, and seratiopeptidase as a drug.

Description

field of invention [0001] The present invention relates to novel substances based on fine pyrogenic silica or fumed silica (commercial drug names SilardP, Silex, Atoxil) containing serrathiopeptidase immobilized on said silica or silica. The composition has activity in lysis of necrotic tissue, can clean wound surface, improves blood supply to tissue, eliminates unpleasant putrid smell and has anti-edema effect. Background of the invention [0002] The treatment of festering wounds with marked tissue necrosis, especially where significant exudate is evident, presents very complex problems due to the fact that very few therapeutic compositions are available for the treatment methods [1, 2]. [0003] Conventional preparations used during contaminated surgery with a rather good antibacterial effect are not sufficiently effective in inhibiting necrosis, where the preparations are really effective, they are in the form of ointments, characterized by low adsorption capacity and ar...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00A01N63/00
CPCA61L2300/404A61L15/18A61L2300/254A61L15/46A61L26/0004A61L26/0047A61L15/38A61L15/44A61L26/0066C12Y304/2404A61P1/04A61P17/02A61P31/00A61P31/04A61K9/0014A61K38/4886A61K47/02A61L26/0095A61K9/1676
Inventor 亚历山大·A·戈卢布O·O·比莱瓦V·V·内斯塔
Owner 亚历山大·A·戈卢布
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