Combined drug for treating insomnia

A technology of medicines and pharmaceutical preparations, applied in the field of drug combination preparations for the treatment of insomnia, can solve unpredictable problems, achieve the effects of easy carrying and taking, enhancing anti-insomnia effect, and reducing clinical dosage

Active Publication Date: 2013-10-30
SICHUAN CREDIT PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Although tizanidine and tandospirone have the effect of treating insomnia respectively, what kind of effect can be brought into play when the two drugs are used in combination, it is difficult for those skilled in the art to predict
At present, there is no report on the combined use of tizanidine hydrochloride and tandospirone citrate in the treatment of insomnia

Method used

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  • Combined drug for treating insomnia
  • Combined drug for treating insomnia

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Embodiment 1 Pharmaceutical tablet of the present invention

[0018] Tablets containing 1 mg of tizanidine hydrochloride and 10 mg of tandospirone were formulated with several pharmaceutical excipients as follows.

[0019] Prescription: Tizanidine Hydrochloride 1 g

[0020] Tandospirone Citrate 10g

[0021] Lactose 80g

[0022] 20g microcrystalline cellulose

[0023] Sodium carboxymethyl starch 4 g

[0024] Ethanol 20ml

[0025] Magnesium Stearate 0.8g

[0026] Made into 1000 pieces

[0027] Preparation method: After mixing tizanidine hydrochloride, tandospirone citrate, lactose, microcrystalline cellulose and sodium carboxymethyl starch in a granulator, add soft materials made of ethanol, vacuum dry, pass Sieve and arrange, then add magnesium stearate, mix evenly, and press into tablets.

Embodiment 2

[0028] Embodiment 2 pharmaceutical tablet of the present invention

[0029] Tablets containing 1 mg of tizanidine hydrochloride and 5 mg of tandospirone were formulated with several pharmaceutical excipients as follows.

[0030] Prescription: Tizanidine Hydrochloride 1 g

[0031] Tandospirone Citrate 5g

[0032] Lactose 80g

[0033] 20g microcrystalline cellulose

[0034] Sodium carboxymethyl starch 4 g

[0035] Ethanol 20ml

[0036] Magnesium Stearate 0.8g

[0037] Made into 1000 pieces

[0038] Preparation method: After mixing tizanidine hydrochloride, tandospirone citrate, lactose, microcrystalline cellulose and sodium carboxymethyl starch in a granulator, add soft materials made of ethanol, vacuum dry, pass Sieve and arrange, then add magnesium stearate, mix evenly, and press into tablets.

Embodiment 3

[0039] Embodiment 3 Pharmaceutical capsules of the present invention

[0040] Prepare hard capsules containing 1 mg of tizanidine hydrochloride and 10 mg of tandospirone citrate in each tablet with several pharmaceutical excipients according to the following method.

[0041] Prescription: Tizanidine Hydrochloride 1 g

[0042] Tandospirone Citrate 10g

[0043] Lactose 80g

[0044] Magnesium Stearate 0.8g

[0045] Make 1000 capsules

[0046] Preparation method: mix tizanidine hydrochloride, tandospirone citrate, lactose, magnesium stearate, sieve, and fill into empty capsules.

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PUM

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Abstract

The invention provides a use of tizanidine hydrochloride and tandospirone citrate in the preparation of a combined drug for treating insomnia. The weight ratio of a tizanidine hydrochloride derivative to the tandospirone citrate is 1-4 to 5-20. The combined drug has the advantages that: (1) from different mechanisms of action, the combined drug has the function of synergistic effect against insomnia; (2) the clinical dosage of one or two drugs can be reduced to attenuate virulence; and (3) the invention can facilitate patients to carry and take.

Description

technical field [0001] The invention relates to a drug combination preparation for treating insomnia, which belongs to the field of drugs. Background technique [0002] At present, both tizanidine and tandospirone have been reported to treat insomnia, such as: Tanaka H et al. in Effects of tizanidine for refractory sleep disturbance in disabled children with spastic quadriplegia, No To Hattatsu. (2004), Nov; 36(6): In the 455-60 period, the research found that tizanidine can be used to improve refractory sleep disorders in children with tetraplegia, and the dosage is 0.1-0.2mg / kg / day, which is divided into two to three times. Liao Duanxiu reported that the use of tandospirone 10mg / tid can effectively improve the sleep state of patients with depression in the treatment of insomnia and anxiety with tandospirone (Chinese and foreign medical treatment, 2008 (9) issue), and the side effects are more commonly used tricyclics To small, such as amitriptyline. Application number: 2...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/433A61K31/506A61P25/20A61J1/03
Inventor 陈刚陈功政鲍文娟吴建容
Owner SICHUAN CREDIT PHARMA
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