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TCM composite for treating skin diseases related to symptoms of blood heat and yang floating and application thereof

A composition and technology of traditional Chinese medicine are applied in the field of traditional Chinese medicine compositions for treating skin diseases related to blood heat and yang floating syndrome, which can solve the problems of insignificant clinical efficacy, lack of traditional Chinese medicine preparations, inconvenience and the like, and achieve safety, no obvious toxic and side effects, and good economy. Benefit, the effect of broad social benefit

Active Publication Date: 2010-07-21
YUEYANG INTEGRATED TRADITIONAL CHINESE & WESTERN MEDICINE HOSPITAL SHANGHAI UNIV OF CHINESE TRADITIONAL MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Traditional Chinese medicine has rich experience in the treatment of atopic dermatitis. It adopts methods such as expelling wind and dampness, clearing away heat and detoxification, nourishing blood and promoting blood circulation, nourishing yin and tonifying kidney, etc. It has achieved considerable clinical curative effect and has a high reputation among patients. However, due to the limitations of many conditions, including pharmaceutical preparations, drug stability, and objective evaluation of clinical efficacy, there is a lack of traditional Chinese medicine preparations for the treatment of atopic dermatitis.
At present, traditional Chinese medicine preparations are mainly used for the clinical treatment of skin pruritus, such as Wushe Zhiyang Pills and Fuyang Granules to treat atopic dermatitis, but the clinical efficacy is not significant
In view of the above situation, Chinese herbal medicines are mainly used to treat atopic dermatitis clinically, which brings great inconvenience to the patients. The development of safe and effective Chinese patent medicines for the treatment of atopic dermatitis will help the disease. The treatment and prevention play an active role in promoting the

Method used

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  • TCM composite for treating skin diseases related to symptoms of blood heat and yang floating and application thereof
  • TCM composite for treating skin diseases related to symptoms of blood heat and yang floating and application thereof
  • TCM composite for treating skin diseases related to symptoms of blood heat and yang floating and application thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] The preparation of embodiment 1 Chinese medicine extract

[0046] Preparation:

[0047] 1. Take the crude drug by weighing the formula in Table 1,

[0048] 2. Extraction:

[0049] The water extraction process is to add about 10 times the amount of water to Moutan cortex or Xu Changqing medicinal materials, soak for 1-3 hours, distill, collect an appropriate amount of distillate, add 7% sodium chloride, salt out for 24 hours (low temperature), and suction filter to obtain Dan The skin phenol crystallizes, and the dregs are used for later use (this step can be omitted for prescriptions without Moutan cortex or Xu Changqing). Add about 10 times the amount of water to oysters, mother-of-pearl, and magnets, fry for 10-30 minutes, then add about 10 times the amount of boiling water, soak for 60 minutes, and add scutellaria baicalensis, comfrey, windproof, licorice, coix seed, vermicelli and the above peonies Moutan cortex or Xu Changqing medicinal residue (the prescription...

Embodiment 2

[0053] The toxicity study of embodiment 2 prescription

[0054] 1. Toxicity pre-test of single drug

[0055] Objective: To preliminarily observe the toxicity of single herb in the compound prescription.

[0056] Method: 3-4 mice (body weight 18-22g) were selected for each drug, fasted overnight, administered orally, and the toxicity and death of the animals were observed.

[0057] The results showed that Xu Changqing and Scutellaria baicalensis in the single herbs had certain toxicity. See Table 4.

[0058] Table 4 Toxic reactions of single herbs

[0059]

[0060] The results showed that in Xu Changqing, although it can reduce inflammation and relieve itching, but the toxicity is relatively high, and the safety range of the single medicine Moutan Cortex is larger than that of Xu Changqing.

[0061] 1. Mixture toxicity test

[0062] Mixture 1: the decoction (containing Xu Changqing) that formula 5 makes according to embodiment 1

[0063] Mixture 2: according to the for...

Embodiment 3

[0068] Embodiment 3 pharmacodynamic research

[0069] experiment method:

[0070] Ear swelling test:

[0071] Method: The mice were randomly divided into 6 groups, 12 in each group, and administered continuously for 5 days. One hour after the last administration, 50ul of xylene was applied to the front and back sides of the right ear of the mice, and the mice were cut off after 20 minutes of application of xylene. The neck was put to death, and the two ears were cut off along the auricle line, and round ears were punched at the same position with a 6mm diameter punch, and weighed with an electronic balance. Swelling inhibition rate, comparing the significant difference between groups. A blank control group was set up, and Fuyang Granules (produced by Sichuan Yada Pharmaceutical Co., Ltd.) were used as a positive control.

[0072] Antipruritic test:

[0073] Method: The guinea pigs were randomly divided into 6 groups, 10 in each group, administered for 5 consecutive days, a...

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Abstract

The invention discloses a TCM (traditional Chinese medicine) composite for treating skin diseases related to the symptoms of blood heat and yang floating and application thereof. The TCM composite of the invention comprises the following components: radix scutellariae, nacre, radix lithospermi, magnetite, radix saposhnikoviae, unripe licorice, unripe semen coicis and unripe concha ostreae. According to the clinical experiments and the results of research on animal effects and toxicology, the TCM preparation prepared from the TCM composite of the invention achieves obvious anti-inflammatory effects and high safety, has no obvious toxicity or side effect and ensures the high clinical effective rate.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine and natural medicine, and in particular relates to a traditional Chinese medicine composition for treating skin diseases related to blood-heat-yang floating syndrome and application thereof. Background technique [0002] Atopic dermatitis (AD, also known as atopic eczema) is one of the most challenging problems in modern dermatology. In recent years, the increasing incidence of AD has made it a prominent public health problem. Although AD can occur in all age groups, the prevalence of AD has increased by 2-3 times in the past 30 years. According to statistics, about 5-20% of children in the world suffer from the disease at present. Epidemiological evidence points to trends in urbanization, as well as Western lifestyles, as factors associated with increased prevalence of AD in recent decades. According to data published in Europe in 1990, it is estimated that the prevalence ...

Claims

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Application Information

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IPC IPC(8): A61K36/8994A61P17/00A61K33/26A61K35/56A61K35/618
Inventor 李斌张宁范斌金若敏李福伦周婉徐玲玲徐蓉年华陈洁
Owner YUEYANG INTEGRATED TRADITIONAL CHINESE & WESTERN MEDICINE HOSPITAL SHANGHAI UNIV OF CHINESE TRADITIONAL MEDICINE
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