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Method for preparing photoactive ternary amphiphilic polyester

An amphiphilic, photoactive technology, applied in the field of functional materials, to achieve excellent biocompatibility, thermal stability, and wide application value

Inactive Publication Date: 2010-07-28
JIANGNAN UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, while polymer materials bring convenience to people's lives and improve the quality of life, a large amount of waste after use is also increasing day by day, causing a non-negligible negative impact on the environment on which human beings depend.

Method used

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  • Method for preparing photoactive ternary amphiphilic polyester
  • Method for preparing photoactive ternary amphiphilic polyester
  • Method for preparing photoactive ternary amphiphilic polyester

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Weigh 3.76g (10mmol) of lithocholic acid, 1.80g (10mmol) of caffeic acid, 0.009g (0.1mmol) of anhydrous sodium acetate, and 35mL of acetic anhydride, add in a 250mL reactor, and heat up to After reacting for 2 hours at 140°C, 1.20 g (3 mmol) of PEG (400) was added dropwise, and finally the temperature was raised to 190-200° C., stirred and reacted at constant temperature for 6 hours. The whole reaction was carried out under nitrogen protection and light-proof conditions. Wash twice with deionized water, dissolve the product in chloroform and precipitate in ethanol after washing, repeat twice, and then dry at a constant temperature at 30°C to obtain a yellow product. The resulting copolymer is:

[0034]

[0035] Expressed as P(LCA-co-DHCA)-b-PEG.

Embodiment 2

[0037] Weigh 3.76g (10mmol) of lithocholic acid, 1.80g (10mmol) of caffeic acid, 0.045g (0.5mmol) of anhydrous sodium acetate, and 35mL of acetic anhydride, add in a 250mL reactor, and heat up to After reacting for 2 hours at 140°C, add 0.76g (10mmol) of 1,3-propanediol dropwise, gradually raise the temperature to 190-200°C, stir, and then react at constant temperature for 6h. The whole reaction is carried out under nitrogen protection and light-proof conditions. Wash twice with deionized water, dissolve the product in chloroform and precipitate in ethanol after washing, repeat twice, and then dry at a constant temperature at 30°C to obtain a yellow product. The resulting copolymer is:

[0038]

[0039] Expressed as P(LCA-co-DHCA-co-PDO).

Embodiment 3

[0041] Weigh 0.082g (0.2mmol) of cholic acid, 1.64g (10mmol) of coumaric acid, 0.018g (0.2mmol) of anhydrous sodium acetate, and 25mL of acetic anhydride, add them to a 250mL reactor, and heat up at a stirring speed of 200r / min After reacting for 1 hour at 160°C, add 0.80 g (2 mmol) of PEG (400) dropwise, gradually raise the temperature to 190-200° C., stir, and then react at constant temperature for 7 hours. The whole reaction is carried out under nitrogen protection and dark conditions. Wash twice with deionized water and twice with acetone, and then dry at a constant temperature at 30° C. to obtain a yellow product. The resulting copolymer is:

[0042]

[0043] Expressed as P(CA-co-4HCA)-b-PEG.

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Abstract

The invention relates to a method for preparing photoactive ternary amphiphilic polyester, belonging to the functional material field. The invention uses lithocholic acid (LCA), cholic acid (CA), 3,4-dihydroxyl cinnamic acid (caffeic acid, DHCA), p-hydroxy-cinnamic acid (cumaric acid, 4HCA), lactic acid (LA), 1,3-propanediol (PDO) and polyethylene glycols (PEG) of different molecular weights as raw materials, anhydrous sodium acetate as a catalyst and acetic anhydride as a solvent, and adopts the stepwise polycondensation method to obtain the photoactive ternary amphiphilic polyester, the molecular weight, the glass transition temperature, the degradation speed and the photocrosslink degree of the obtained polyester are all controllable, and the amphiphilic polyester forms a micelle by self assembly. The preparation method is simple, and the prepared ternary amphiphilic polyester has good photoactivity, biological compatibility and thermal stability and can be widely used as degrading materials in the fields of medicinal slow-release systems, tissue engineering, packaging material, environmental protection and the like.

Description

technical field [0001] The invention discloses a method for preparing a photoactive ternary amphiphilic polyester, which belongs to the field of functional materials. Background technique [0002] With the development and application of new technologies, various new polymer materials have sprung up, playing a pivotal role in people's production and life. However, while polymer materials bring convenience to people's lives and improve the quality of life, a large amount of waste after use is also increasing day by day, causing a non-negligible negative impact on the environment on which human beings depend. In addition, the raw material for the production of polymer materials - oil will always be exhausted one day. Based on current consumption, it is estimated that mineral resources such as petroleum for manufacturing materials will be exhausted in 80 years. Therefore, it is extremely urgent to find new raw materials for environmentally friendly polymer materials and to dev...

Claims

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Application Information

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IPC IPC(8): C08G63/78C08G63/664C08G63/06
Inventor 陈明清李会玲章辉东为富李继航倪忠斌黎昌虎高虎
Owner JIANGNAN UNIV
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