Drying method of grape seed proanthocyanidin extract

A technology of proanthocyanidin and drying method, applied in the direction of organic chemistry, etc., can solve the problems of high energy consumption and production cost, large investment in freeze-drying equipment, affecting product quality and yield, etc., so as to maintain physical and chemical properties and production capacity Large, low moisture content

Inactive Publication Date: 2012-07-11
ZHEJIANG UNIV
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  • Application Information

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Problems solved by technology

The freeze-drying method can better maintain the antioxidant properties of proanthocyanidins, but the investment in freeze-drying equipment is large, the energy consumption and production cost are high, and it is not suitable for large-scale industrial production
The spray drying method can be used for continuous production, but there is a serious problem of sticking to the wall during the drying process, which affects product quality and yield
In addition, the temperature of the hot air flow during the spray drying process can be as high as 200-300°C, which easily destroys the activity of the product, and the obtained dry powder is too fine rather than granular, and has poor water solubility

Method used

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  • Drying method of grape seed proanthocyanidin extract
  • Drying method of grape seed proanthocyanidin extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] see figure 1 , the density is 1145kg / m 3 The proanthocyanidin extract is preheated to 30°C in the vacuum belt dryer feed tank 1, and is evenly coated on the conveyor belt 3 by the swing of the distributor 2 at a feed rate of 1.4kg / h under vacuum conditions. On the top, the conveyor belt runs at a speed of 2.4m / h, and the proanthocyanidin extract passes through the first heating section 4 with a temperature of 80°C and the second heating section 5 with a temperature of 80°C along with the conveyor belt, and finally passes through a temperature of 25~ The cooling section 6 at 35°C forms a continuous, porous and loose dry extract. When the dry extract reaches the end of the equipment, the scraper set at the end scrapes it off the conveyor belt and falls into the shredder. , the crushed dry extract enters the product collection tank. Measured by the first method of moisture determination in the appendix of "Chinese Pharmacopoeia", the moisture content of the dry extract i...

Embodiment 2

[0018] see figure 1 , with the extractant in Example 1 at a feed rate of 2.1kg / h, on the basis that the rest of the conditions are the same, adjust the temperature of the first heating section 4 to be 90°C, and the temperature of the second heating section 5 to be 90°C, The temperature of the cooling section 6 is 25-35°C. The moisture content of the dry extract is 1.06%, and the drying speed is 1.23kg / h.

Embodiment 3

[0020] see figure 1 , with the extractant in Example 1 at a feed rate of 2.8kg / h, on the basis that the rest of the conditions are the same, adjust the temperature of the first heating section 4 to be 100°C, and the temperature of the second heating section 5 to be 100°C, The temperature of the cooling section 6 is 25-35°C. Measured by the first method of water determination in the appendix of "Chinese Pharmacopoeia", the moisture content of the dry extract is 0.23%, and the drying speed is 1.65kg / h.

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Abstract

The invention provides a drying method of grape seed proanthocyanidin extract. Proanthocyanidin extract is preheated in a vacuum band-type drier head tank and is evenly sprayed on a conveyer belt by the swinging of a charge distributor under the vacuum condition; the extract successively passes through two heating sections and one cooling section along with the conveyer belt to form a dark red, continuous and loose dry extract; and when reaching the tail end of the device, the dry extract is scraped from the conveyer belt by a scraper blade arranged on the tail end and falls into an auger pulverizator, and the pulverized dry extract enters a product gathering tank. The invention adopts a continuous operation mode, has moderate drying process, short time, large production capability and whole sealing operation environment, avoids the cross contamination of people and materials, and furthest keeps the physical property and the chemical property of proanthocyanidin; and the dry extract has low moisture content and favorable dissolubility, is porous and loose and conforms to the GMP requirement.

Description

technical field [0001] The invention belongs to the technical field of drying traditional Chinese medicine extracts, and relates to a drying method for grape seed proanthocyanidin extracts. The dry proanthocyanidin extracts obtained by the method have the characteristics of low water content, porous and loose, and good solubility. Background technique [0002] Proanthocyanidins are composed of (+)-catechin, (-)-epicatechin and (-)-epicatechin gallate through C 4 -C 8 key or c 4 -C 6 Polyphenols with different degrees of polymerization formed by bonds are widely found in plants such as grapes, blueberries, cherries, plums and pine bark, among which grape seeds are an important source of proanthocyanidins. Proanthocyanidins (GPC) has a strong anti-oxidation effect, high absorption by the human body, can remove free radicals and active oxygen in the body, and prevent arteriosclerosis caused mainly by the oxidation of low-density lipoprotein (LDL) in human blood. It also has...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D311/62
Inventor 栾连军刘雪松陈娜吴永江陈勇王龙虎
Owner ZHEJIANG UNIV
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