Application of MPEG-PLA (Methoxypolyethylene Glycols-Polylactic Acid) diblock copolymers in preparation of medical anti-blocking material

A technology of MPEG5000-PLA4000, block copolymer, applied in the field of medical polymer materials, can solve the problems of complex synthesis method, reduced yield, safety problems and the like

Inactive Publication Date: 2010-08-18
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this three-block copolymer needs to be synthesized in two steps, and an isocyanate coupling agent is required, which not only complicates the synthesis method, but also reduces the yield and has potential safety problems.
[0005] At present, other medical anti-adhesion materials that can be used in this field either need to be dissolved in organic solvents, which is not conducive to human safety; or the anti-adhesion effect is not good, and the price is expensive, and it is difficult to transport and store; Security risks

Method used

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  • Application of MPEG-PLA (Methoxypolyethylene Glycols-Polylactic Acid) diblock copolymers in preparation of medical anti-blocking material
  • Application of MPEG-PLA (Methoxypolyethylene Glycols-Polylactic Acid) diblock copolymers in preparation of medical anti-blocking material
  • Application of MPEG-PLA (Methoxypolyethylene Glycols-Polylactic Acid) diblock copolymers in preparation of medical anti-blocking material

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Synthesis and verification of embodiment one MPEG-PLA diblock copolymer

[0036] 1) Synthesis of MPEG-PLA copolymer

[0037] The brief synthetic route of MPEG-PLA copolymer of the present invention is as follows:

[0038] MPEG+L-LA(DL-LA)→MPEG-PLLA or MPEG-PDLLA

[0039] Among them, the molecular weights of MPEG are 2000 Daltons and 5000 Daltons respectively. By controlling the molar ratio of MPEG and L-LA (DL-LA), a series of MPEG-PLA copolymers are synthesized. The obtained materials are listed in Table 1 middle.

[0040] According to the synthetic route of the above formula, a certain amount of polyethylene glycol monomethyl ether (MPEG) and lactide (L-LA or DL-LA) are added in a three-necked flask equipped with a stirrer, and stannous octoate is used as a catalyst , reacted for 6 hours at 130°C under nitrogen protection, cooled to 80°C, cooled to room temperature for purification, and dried.

[0041] According to the method described above, the MPEG 2000 -PLA ...

Embodiment 2

[0049] Embodiment two uses MPEG-PLA copolymer to prepare into medical anti-adhesion material

[0050] The MPEG-PLA copolymer prepared by using the above embodiment is prepared into a medical anti-adhesion material. Here we cite MPEG 5000 -PLLA 4000 For example, first dissolve the copolymer in physiological saline at a concentration of 15-40 wt%, preferably about 25 wt%, and stir thoroughly to mix evenly. The mixed physiological saline solution was heated and stirred at 50°C for about 5 minutes to form a translucent viscous liquid, which was cooled to below 4°C for use. There are two methods of use: a: inject the sol-like hydrogel around the wound, and form a gel by increasing the temperature. B: The sol-like hydrogel is refrigerated at below 4°C for more than 24 hours. Through crystallization, the hydrogel is completely gelled. When applied, it is directly applied to the wound surface of the abdominal cavity. Considering the convenience of use and storage, we choose to ado...

Embodiment 3

[0050] The MPEG-PLA copolymer prepared by using the above embodiment is prepared into a medical anti-adhesion material. Here we cite MPEG 5000 -PLLA 4000 For example, first dissolve the copolymer in physiological saline at a concentration of 15-40 wt%, preferably about 25 wt%, and stir thoroughly to mix evenly. The mixed physiological saline solution was heated and stirred at 50°C for about 5 minutes to form a translucent viscous liquid, which was cooled to below 4°C for use. There are two methods of use: a: inject the sol-like hydrogel around the wound, and form a gel by increasing the temperature. B: The sol-like hydrogel is refrigerated at below 4°C for more than 24 hours. Through crystallization, the hydrogel is completely gelled. When applied, it is directly applied to the wound surface of the abdominal cavity. Considering the convenience of use and storage, we choose to adopt the second method, that is, refrigerate the sol-like hydrogel for more than 24 hours at 4°C, ...

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Abstract

The invention relates to the field of medical high polymer materials, in particular to an application of MPEG-PLA (Methoxypolyethylene Glycols-Polylactic Acid) diblock copolymers in preparation of medical anti-blocking materials. The invention aims at providing a new selection for the medical anti-blocking material. The technical scheme for the technical problem is to provide the application of MPEG-PLA diblock copolymers in preparation of medical anti-blocking materials. The molecular weight of the MPEG-PLA copolymer is 3,000-12,000, wherein the ratio of the molecular weight of a PEG (Polyethylene Glycol) chain segment to the molecular weight of a PLA (Polylactic Acid) chain segment is 0.8-2, the copolymer can be dissolved in water to form a solution and can also form gel under certain conditions. The experimental result shows that the MPEG-PLA block copolymer hydrogel can be applied to medical anti-blocking materials with multiple excellent characteristics and provides a new selection for the field needing the medical anti-blocking materials.

Description

technical field [0001] The invention relates to the field of medical polymer materials, in particular to the use of MPEG-PLA diblock copolymers in preparing medical anti-adhesion materials. Background technique [0002] Postoperative adhesion is a difficult problem that has not been solved for a long time in the field of surgery. So far people are looking for various methods to prevent postoperative adhesions, but the clinical effects of the current technical solutions are not satisfactory, and it is difficult to meet the ideal clinical requirements. In recent years, it has become a common practice in the world to prevent postoperative adhesions by implanting isolation materials in areas prone to postoperative adhesions. Anti-adhesion film, anti-adhesion gel, anti-adhesion liquid, etc., the above materials have their own advantages, but also have their shortcomings. People hope to develop a kind of easy-to-use anti-adhesion gel similar to the state of toothpaste, so as to ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/765A61P41/00A61L31/06
Inventor 钱志勇魏于全赵霞
Owner SICHUAN UNIV
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