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Calculus bovis factitius superfine powder and preparation method

A technology of artificial bezoar and ultra-fine powder, which is applied in powder delivery, pharmaceutical formula, medical preparations containing active ingredients, etc. It can solve the problems of difficulty in fully exerting the efficacy of drugs, low absorption of artificial bezoar, and difficulty in artificial bezoar. To achieve the effect of inhibiting the formation of cotton ball granuloma, enhancing clinical efficacy and promoting ulcer healing

Active Publication Date: 2011-11-30
MAYINGLONG PHARMA GROUP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The clinical efficacy of artificial bezoar is roughly similar to that of natural bezoar, but artificial bezoar is insoluble in water. The artificial bezoar prepared by traditional technology has low absorption and slow onset of action, making it difficult to fully exert its efficacy

Method used

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  • Calculus bovis factitius superfine powder and preparation method
  • Calculus bovis factitius superfine powder and preparation method
  • Calculus bovis factitius superfine powder and preparation method

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Embodiment Construction

[0036] The dosage of the medicine of the present invention is as follows (parts by weight):

[0037]

[0038] A preparation method of artificial bezoar superfine powder, its steps are:

[0039] A. First, mix artificial bezoar, sodium lauryl sulfate and distilled water to prepare artificial bezoar suspension, disperse twice with a high-speed disperser (10000rpm), each time for 8 or 9 or 10 or 11 or 12 minutes ;

[0040] B. Homogenize the dispersed suspension through a high-pressure homogenizer (150~300Bar) for 22 or 23 or 24 or 25 or 26 or 27 or 28 minutes;

[0041] C. Use a high-pressure homogenizer (1000~2000Bar) to homogenize the above-mentioned homogeneous suspension for twelve or thirteen or fourteen or fifteen or sixteen or seventeen or eighteen times, 28 or 29 each time Or 30 or 31 or 32 minutes, collect artificial bezoar suspension;

[0042] D. Pre-freeze the artificial bezoar suspension at 18 or 19 or 20 or 21 or below 22°C, and the pre-freeze cooling rate is -2°C / min;

[0043]...

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Abstract

The invention discloses calculus bovis factitius superfine powder and a preparation method. A medicament is prepared from the calculus bovis factitius, lauryl sodium sulfate and distilled water in a certain proportion by weight. The preparation method comprises the following steps: A, uniformly mixing the calculus bovis factitius, the lauryl sodium sulfate and the distilled water to prepare the calculus bovis factitius suspension, and then dispersing the suspension by using a high speed disperser; B, homogenizing the dispersed suspension by using a high pressure homogenizer; C, uniformly cycling the homogenized suspension by using the high pressure homogenizer , and collecting the calculus bovis factitius suspension; D, prefreezing the calculus bovis factitius suspension; and E, moving the prefrozen calculus bovis factitius suspension into a drying chamber, then vacuumizing and heating the calculus bovis factitius suspension, and collecting the frozen powder. The method has the advantages of obviously improving absorbency of the calculus bovis factitius, along with simple process, easy operation, and suitability for industrial production.

Description

Technical field [0001] The invention relates to a mineral Chinese medicine powder technique, more specifically to an artificial bezoar superfine powder, and also to a preparation method of the artificial bezoar superfine powder. Bezoar is a traditional precious Chinese medicinal material. It is mostly a component of traditional Chinese medicine compound preparations and has a wide range of clinical applications. Many commonly used Chinese patent medicines contain bezoar components, such as Angong Niuhuang Pills, Niuhuang Jiedu Tablets, Liushen Pills and so on. Background technique [0002] Nanotechnology is a brand-new way of manipulating atoms and molecules in the space scale of 0.1-100nm, processing materials to produce products with specific functions, or researching certain substances, and mastering the laws and characteristics of their atoms and molecules. High-tech disciplines. [0003] Nanotechnology has gradually been applied to the field of traditional Chinese medicine p...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K35/413A61K9/14A61P25/08A61P25/00A61P11/04A61P17/02A61P1/02
Inventor 陈平严常开
Owner MAYINGLONG PHARMA GROUP
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