Preparation method and application of Cyrtomium fortunei and ebony traditional Chinese medicine composite

A composition and the technology of Guanzhong, which are applied in the field of medicine, can solve the problems of no curative effect of the two extracts, achieve good preventive and therapeutic effects, simple preparation process, and easy-to-obtain raw materials

Active Publication Date: 2010-08-18
广东省天宝生物制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there is no report on the compatibility of Guanzhong and Wumei extracts at home and abroad, and there ...

Method used

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  • Preparation method and application of Cyrtomium fortunei and ebony traditional Chinese medicine composite
  • Preparation method and application of Cyrtomium fortunei and ebony traditional Chinese medicine composite
  • Preparation method and application of Cyrtomium fortunei and ebony traditional Chinese medicine composite

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Effect test

Embodiment 1

[0037] The preparation of embodiment 1 rhizome extract

[0038] a. Take 1Kg Guanzhong, crush it, soak it with 6 times the volume of 75% ethanol for 8 hours, pour the Guanzhong and ethanol extract into a three-necked flask and put it on the electric heating mantle for electronic temperature regulation, and keep boiling for 1 hour after boiling hour, the extract was poured out and suction filtered to obtain the supernatant for subsequent use;

[0039] b. Add 4 times the volume of 75% ethanol to the liquor poured out of the extract, boil, keep boiling for 1 hour, pour out the extract and suction filter to obtain the supernatant for later use;

[0040] c. Repeat step b2 times;

[0041] d. Combine the supernatants and concentrate under reduced pressure to obtain 202 grams of extract for subsequent use, with a yield of 20.2%.

Embodiment 2

[0042] The preparation of embodiment 2 ebony extract

[0043] a. Take 1Kg ebony plum, soak it with 6 times the volume of 75% ethanol for 8 hours, pour the ebony plum and the ethanol extract into a three-necked flask and put it on an electronic thermostat electric heating mantle, keep boiling for 1 hour after boiling, and pour the ebony extract into a three-necked flask. The extract was poured out and suction filtered to obtain the supernatant for subsequent use;

[0044] b. Add 4 times the volume of 75% ethanol to the ebony plum from which the extraction solution has been poured out, boil, keep boiling for 1 hour, pour out the extraction solution and suction filter to obtain the supernatant for subsequent use;

[0045] c. Repeat step b2 times;

[0046] d. Combine the supernatants and concentrate under reduced pressure to obtain 307g extract for subsequent use, with a yield of about 30.7%.

Embodiment 3

[0047] The preparation of embodiment 3 compound Guanzhong Wumei oral liquid

[0048] Dissolve the extracts of Rhododendron japonicus and the extracts of ebony plums with 75% alcohol respectively, add Tween-20, and then add 20wt% cinnamic acid in absolute ethanol solution. Wherein the consumption of 75% alcohol is 30% of the final volume, Tween-20 accounts for 40%, and water accounts for 30%. The drug is prepared by combining guanzhong, ebony extract extract and cinnamic acid in a weight ratio of 9:1:5 to prepare a liquid with a drug concentration of 200mg / mL as the active ingredient guanzhong ebony. The compound is a dark brown liquid, and there is an extract that can easily disperse when stored for a long time.

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Abstract

The invention provides a Cyrtomium fortunei and ebony traditional Chinese medicine composite. The composite is a mixture of the alcohol extract of Cyrtomium fortunei, the alcohol extract of ebony and cinnamic acid in a certain ratio or an extract prepared by carrying out alcohol extraction after ebony and Cyrtomium fortunei are mixed in a certain ratio, and the composite also contains conventional pharmaceutic adjuvants and excipients. The invention also provides a preparation method and application of the Cyrtomium fortunei and ebony traditional Chinese medicine composite. The Cyrtomium fortunei and ebony traditional Chinese medicine composite has good prevention and treatment effects on poultry bacterial diseases and virus diseases, especially poultry diseases caused by escherichia coli and chlamydia and poultry diseases caused by bursal disease viruses and avian influenza. Moreover, the Cyrtomium fortunei and ebony traditional Chinese medicine composite has available raw material, lower cost and convenient and easy preparation process.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to a traditional Chinese medicine composition of guanzhong ebony, its preparation method and application. Background technique [0002] The widespread emergence of bacterial resistance and drug-resistant infections have become a major problem affecting the development of modern animal husbandry. In the farming industry, it is expected to reduce the emergence of drug-resistant bacteria through rational use of drugs and to deal with the continuous emergence of drug-resistant bacteria through the development of new drugs, which just provides opportunities for the research of anti-infection of traditional Chinese medicine. Major livestock and poultry diseases continue to break out all over the world, and major public health diseases such as avian influenza and foot-and-mouth disease have seriously affected the development of animal husbandry. Therefore, the research of anti-poultry bacterial dise...

Claims

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Application Information

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IPC IPC(8): A61K36/736A61K9/20A61K9/16A61K9/00A61K9/19A61P31/04A61P31/12A61P31/16A61K31/192
Inventor 何诚李国清欧长波李国祥李树梅陈宝玉张裕祥
Owner 广东省天宝生物制药有限公司
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