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Scaffold material capable of inducing biological hard tissue or soft tissue

一种支架材料、硬组织的技术，应用在机体硬组织或软组织诱导性支架材料领域，能够解决无法满足骨性结合状态等问题，达到容易成长、着床性优良、制造容易的效果

Active Publication Date: 2010-08-25
HI-LEX CORPORATION +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] However, it has been found that the implant material having the above-mentioned geometric structure penetrates into the implant material of osteoblasts, and cannot satisfy the state of osseointegration integrated with the cells.

Method used

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  • Scaffold material capable of inducing biological hard tissue or soft tissue
  • Scaffold material capable of inducing biological hard tissue or soft tissue
  • Scaffold material capable of inducing biological hard tissue or soft tissue

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0112] production Figure 5 artificial tooth root 40. Here, the internal thread formed on the inner surface of the introduction hole 44 is not formed. The base material 41 is formed by filling a mold with a titanium metal wire with a diameter of 80 μm and sintering it so that the diameter of the flange portion 43 is 4 mm, the diameter of the introduction hole 44 is 2 mm, the length is 3 mm, and the average hole diameter is 80 μm.

[0113] In addition, the cell induction layer 42 is wound with a metal nonwoven fabric formed by entangling titanium metal wires with a diameter of 80 μm so that the average pore diameter is 200 μm.

[0114] Furthermore, a titanium rod was installed in the introduction hole 44, and they were bonded by vacuum sintering to form an artificial tooth root. The base material 41 of the artificial tooth root 40 thus formed corresponds to the bonding layer of the present invention, and the cell-inducing layer 42 corresponds to the metal fiber layer.

Embodiment 2

[0151] A culture chassis in which the titanium fiber mesh of Example 1 was inserted into a bottomed cylindrical titanium frame was manufactured. Set as Example 2.

[0152] [Comparative example 1]

[0153] A plastic case made of a conventionally known flat plastic dish was used as Comparative Example 1.

[0154] Fibroblasts in Examples 1 and 2 and Comparative Example 1 were seeded, soaked in a culture solution, and cultured for 2 weeks. Figure 17 Indicates the production amount of collagen produced by fibroblasts at this time. It can be seen from the figure that when cultured with the culture chassis (Example 1) used in the culture method of the present invention, the production of collagen was increased by 1.4 times compared with the usual plastic box. Furthermore, when the culture was carried out in the culture base plate (Example 2) equipped with a rack, the production of collagen was increased by 1.8 times compared with the usual plastic box.

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Abstract

The invention provides an implant material which exhibits relatively high mechanical binding with an osteoblast and also high strength. A scaffold material (10) capable of inducing a biological hard tissue, which comprises a rod (11) having a trunk portion (21) and bride girders (22), a binding layer (13) formed on the periphery of the rod and a metal fiber layer (14) formed on the periphery of the binding layer, and which further has a reinforcing layer (15) formed on the periphery of the metal fiber layer (14). The binding layer (13) has pores having an average pore size of less than 100 mum, and the metal fiber layer (14) has pores having an average pore size of 100 to 400 mum.

Description

[0001] This application is a divisional application of Chinese Patent Application No. 200580036406.4 with the same title of invention, the original international application number is PCT / JP2005 / 017655, and the international filing date is September 26, 2005. technical field [0002] The present invention relates to a kind of body hard tissue or soft tissue inductive bracket material (hereinafter referred to as bracket) used for artificial tooth root implantation, artificial joint implantation, bone fixation support such as bone plate, replacement bone or artificial viscera and its holding device Material). Furthermore, the present invention relates to a method for culturing cells and microorganisms, a method for producing biologically derived substances (especially medical collagen) using the method, and a device used in these methods. Background technique [0003] Patent Document 1: Japanese Unexamined Patent Publication No. 11-341 [0004] Patent Document 2: Japanese Une...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/34A61L27/32A61L27/04A61L27/56A61L27/54A61L27/60A61L31/10A61L31/08A61L31/02A61L31/16A61K6/04A61K6/033A61K6/02C12N5/00C12N1/00C12P21/02C12M1/00C12M3/00C12N5/071C12N5/07C12N5/077
CPCA61F2002/30011A61F2/28A61L27/56A61L27/04A61F2310/00568A61F2250/0023A61F2/34A61F2/30767A61F2002/3092A61F2/30965A61F2310/00155A61F2310/00976A61F2/30756A61C8/0018A61C8/0012A61F2/32A61L27/30A61F2002/4648A61F2002/30968A61B17/80A61F2310/00407A61F2002/30766A61F2002/30762A61F2310/00023A61F2310/00796
Inventor 久保木芳德关康夫盐田博之
Owner HI-LEX CORPORATION