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Pharmaceutical composition, injection and preparation method for treating livestock toxoplasmosis

A technology for toxoplasmosis and injection, which is applied in the directions of drug combination, drug delivery, and pharmaceutical formulation, can solve the problems of large toxic and side effects, unsatisfactory curative effect, and inability to cure, achieve low toxic and side effects, relieve symptoms of high fever, The effect of preventing secondary infection

Inactive Publication Date: 2012-02-01
HENAN HUITONGTIANXIA ANIMAL MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] At present, the routine treatment of toxoplasmosis generally adopts oral sulfa drugs, pyrimethamine, spiramycin and lincomycin, etc., but these drugs have long treatment course, serious side effects, unsatisfactory curative effect, and cannot cure And other issues

Method used

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  • Pharmaceutical composition, injection and preparation method for treating livestock toxoplasmosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] 1. The pharmaceutical composition for the treatment of livestock toxoplasmosis consists of the following components by weight percentage:

[0045] Sulfamethoxine 18%

[0046] Sulfamethoxazole 55%

[0047] Trimethoprim 7%

[0048] Pyrimethamine 14%

[0049] Diclofenac Sodium 6%.

[0050] 2. The injection for the treatment of livestock toxoplasmosis consists of the following components by weight percentage:

[0051] Sulfamethoxine 5%

[0052] Sulfamethoxazole 15%

[0053] Trimethoprim 2%

[0054] Pyrimethamine 3%

[0055] Diclofenac Sodium 1.5%

[0056] Polyethylene Glycol-400 5%

[0057] Propylene Glycol 20%

[0058] Alpha-Pyrrolidone 45%

[0059] Sodium sulfite 0.1%

[0060] Disodium EDTA 0.01%

[0061] The balance is water for injection.

[0062] 3. The preparation method of the injection for the treatment of livestock toxoplasmosis is carried out according to the following steps:

[0063] (1) Heat the mixed solution of polyethylene glycol-400, propylene...

Embodiment 2

[0067] 1. The pharmaceutical composition for the treatment of livestock toxoplasmosis consists of the following components by weight percentage:

[0068] Sulfamethoxine 20%

[0069] Sulfamethoxazole 52%

[0070] Trimethoprim 8%

[0071] Pyrimethamine 13%

[0072] Aspirin 7%.

[0073] 2. The injection for the treatment of livestock toxoplasmosis consists of the following components by weight percentage:

[0074] Sulfamethoxine 5.5%

[0075] Sulfamethoxazole 14.5%

[0076] Trimethoprim 2.2%

[0077] Pyrimethamine 3%

[0078] Aspirin 2%

[0079] Polyethylene glycol-400 6%

[0080] Propylene Glycol 22%

[0081] Alpha-Pyrrolidone 35%

[0082] Sodium bisulfite 0.11%

[0083] Disodium EDTA 0.02%

[0084] The balance is water for injection.

[0085] 3. The preparation method of the injection for the treatment of livestock toxoplasmosis is carried out according to the following steps:

[0086] (1) Heat the mixed solution of polyethylene glycol-400, propylene glycol and α...

Embodiment 3

[0090] 1. The pharmaceutical composition for the treatment of livestock toxoplasmosis consists of the following components by weight percentage:

[0091] Sulfamethoxine 22%

[0092] Sulfamethoxazole 55%

[0093] Trimethoprim 9%

[0094] Pyrimethamine 6%

[0095] Magnesium Salicylate 8%.

[0096] 2. The injection for the treatment of livestock toxoplasmosis consists of the following components by weight percentage:

[0097] Sulfamethoxine 6%

[0098] Sulfamethoxazole 15%

[0099] Trimethoprim 2.5%

[0100] Pyrimethamine 1.6%

[0101] Magnesium Salicylate 2.2%

[0102] Polyethylene glycol-400 7%

[0103] Propylene Glycol 24%

[0104] Alpha-Pyrrolidone 40%

[0105] Sodium metabisulfite 0.12%

[0106] Disodium EDTA 0.02%

[0107] The balance is water for injection.

[0108] 3. The preparation method of the injection for the treatment of livestock toxoplasmosis is carried out according to the following steps:

[0109] (1) Heat the mixed solution of polyethylene glyco...

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Abstract

A pharmaceutical composition for treating toxoplasmosis in domestic animals, an injection and a preparation method thereof. The pharmaceutical composition is composed of the following components by weight percentage: 18-36% of sulfamethoxazole, 16-65% of sulfamethoxazole, 7-18% of trimethoprim, 4-14% of pyrimethamine, non Steroidal anti-inflammatory drugs 6 to 16%. The injection consists of the following components by weight percentage: 5-10% of sulfamethoxazole, 4-20% of sulfamethoxazole, 2-5% of trimethoprim, 1-3% of pyrimethamine, non-steroidal Body anti-inflammatory drugs 1.5-4%, polyethylene glycol-400 5-10%, propylene glycol 10-30%, α-pyrrolidone 30-60%, antioxidant 0.1-0.2%, metal complexing agent 0.01-0.02% , and the balance is water for injection. In the present invention, sulfamethoxine, sulfamethoxazole, trimethoprim and pyrimethamine are used in combination, and a composite solvent is used to prepare a long-acting preparation, which prevents secondary infection of other pathogens while driving and killing Toxoplasma gondii, thereby alleviating the Different symptoms and complications caused by Toxoplasma gondii.

Description

technical field [0001] The invention relates to a veterinary drug, in particular to a pharmaceutical composition, an injection and a preparation method thereof for treating toxoplasmosis in livestock. Background technique [0002] Toxoplasmosis is a zoonotic disease caused by Toxoplasma gondii. It has a wide range of hosts and can infect most hosts including humans. Toxoplasma gondii is an obligate intracellular parasite, which can infect various cells of vertebrates, multiply in the cells, and finally destroy the host cells and release parasites, leading to a series of pathological changes. In the body with normal immune function, it is mostly recessive infection. If the body's immune function is impaired, the recessive infection can cause acute attack and endanger life. The entire development process of Toxoplasma gondii requires two hosts, cats are the final host, and more than 200 species of intermediate hosts are currently known, including mammals, birds, reptiles, fis...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/635A61K31/505A61K45/00A61K31/196A61P33/02A61K47/10A61K47/22A61K9/08A61J3/00
Inventor 张要齐张新蕾孙雪峰朱静静
Owner HENAN HUITONGTIANXIA ANIMAL MEDICINE