Preparation method of L-carnitine nitrate

A technology of nitrate and carnitine, which is applied in the field of preparation of L-carnitine nitrate to achieve the effects of cost reduction, process saving and mild reaction conditions

Inactive Publication Date: 2010-09-01
TIANJIN TIANCHENG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no industrialized production of L-carnitine nitrate products in the world at present

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Add 94 kg of 68% nitric acid dropwise to 162 kg of L-carnitine while stirring at a temperature of 20°C±2°C, and then heat to 60°C±5°C, and the solution gradually becomes clear as the temperature rises. Measure the pH value before the end of the reaction, and adjust the pH of the solution to 2 with nitric acid. After the solution was clarified, the stirring was continued for 20 minutes. Then keep the temperature at 60°C±5°C for dehydration under reduced pressure, and keep the vacuum degree above 500 mmHg. Stir and air-dry the reactant obtained by dehydration at 55°C±5°C, and then dry it at 80°C to obtain the finished product of L-carnitine nitrate.

Embodiment 2

[0024] Add 94 kg of 68% nitric acid dropwise to 162 kg of L-carnitine under stirring at 20°C±2°C, control the rate of nitric acid addition and temperature rise, until the drop has reached 50°C, no external heating is required. The solution gradually clarified as the temperature increased. Measure the pH value before the end of the reaction, and adjust the pH of the solution to 2 with nitric acid. After the solution was clarified, the stirring was continued for 25 minutes. Then keep the temperature of 50°C±5°C for dehydration under reduced pressure, and keep the vacuum degree above 500 mmHg. Stir and air-dry the reactant obtained by dehydration within the range of 65°C ± 5°C, and continue drying at 80°C to obtain the finished product of L-carnitine nitrate.

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PUM

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Abstract

The invention discloses a preparation method of L-carnitine nitrate, comprising the following steps of: dripping nitric acid into L-carnitine while stirring under the temperature of 10 to 25 DEG C, wherein the mol ratio of the L-carnitine to the nitric acid is 1: 1-1.1; gradually clarifying the solution at the reaction temperature of 40 to 70 DEG C; regulating the pH value of the solution to be 1to 2 by using the nitric acid; continuously stirring the clarified solution, preserving the temperature for 15 to 30min and then compressing and dehydrating, stirring and air-drying at 50 to 70 DEG C, and drying at 75 to 80 DEG C to obtain an L-carnitine nitrate finished product. In the invention, the L-carnitine and the nitric acid are reacted under the ordinary pressure, and therefore, the reaction conditions are mild. In the preparation method, the food-grade L-arginine and the high-purity nitric acid are adopted as raw materials, therefore, the produced L-carnitine nitrate has good quality and high purity up to more than 99 percent without crystallization; not only the quality is ensured, but also the working procedures are saved. The production efficiency is improved and the yield coefficient is high and is up to more than 98 percent. The preparation method has reasonable and simple process and can be suitable for industrial large production.

Description

technical field [0001] The invention relates to a method for preparing amino acid nitrate, in particular to a method for preparing L-carnitine nitrate with good quality, high yield and low cost. Background technique [0002] L-carnitine (L-carnitine), also known as L-carnitine. Another name L-carnitine, vitamin BT. The chemical name is beta-hydroxygamma-trimethylammonium butyric acid. It is a kind of amino acid that promotes the conversion of fat into energy. No toxic side effects on the human body. L-carnitine exists widely in muscle as an alkaline component, and it can usually be extracted from the meat of pigs, calves, horses, etc. [0003] Existing literature shows that L-carnitine is extremely important for the growth and development, reproduction and health of animals. It has important physiological functions such as promoting the β-oxidation of fatty acids, reducing the content of serum cholesterol and triglycerides, and improving the body's tolerance. [0004] ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C229/22C07C227/18
Inventor 张国基
Owner TIANJIN TIANCHENG PHARMA
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